Neonatal Lupus Erythematosus

Hon, Kam Lun; Leung, Alexander K C

doi:10.1155/2012/301274

Cited by 61 publications

(65 citation statements)

References 42 publications

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“…Hydrocephaly, calcification of the basal ganglia, and vasculopathy are also reported (10). Hematologic findings including hemolytic anemia, thrombocytopenia, and leukopenia are other transient manifestations (2,11).…”

Section: Discussionmentioning

confidence: 99%

“…Although dermatological manifestations commonly occur in exposed areas after sun exposure, it may also be seen immediately after birth without any sun exposure (2). This manifestation is transient and rarely leaves atrophic scars (2). Cardiac disease with third-degree heart block is the most common cardiac manifestation, however, the other less common manifestations are myocarditis, cardiomyopathy often with endocardial fibroelastosis, and valvular lesions causing stenosis, regurgitation, and dysplasia due to inflammation and fibrosis (1).…”

Section: Discussionmentioning

confidence: 99%

“…It is caused by transplacental passage of maternal autoantibodies against Ro/SS-A, La/SS-B, and U1 ribonucleoprotein (2). Although skin rash and congenital heart disease are the most common manifestations of the disease, it has systemic involvements (3).…”

Section: Introductionmentioning

confidence: 99%

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Methylprednisolone Pulse Therapy Can Be Life-Saving in Neonatal Lupus Erythematous: A Case Report

et al. 2017

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Introduction: Neonatal lupus erythematous (NLE) is a neonatal autoimmune disease, due to passage of maternal autoantibodies against Ro/SS-A, La/SS-B, and U1-ribonucleoprotein, with multi organ involvement. Although the clinical manifestations of NLE include cutaneous, cardiac, hematologic, and hepatobiliary system involvement, the most common clinical manifestations are skin rash and heart involvement. Congenital heart block in the absence of structural cardiac abnormalities is the most commonly observed manifestation. The most clinical manifestations of NLE are self-limited and resolve without serious treatment, except heart block that may need a pacemaker. In rare instances, more severe complications may occur, and necessitate more aggressive immune suppressive therapy. Case Presentation: Here we present a neonate girl who developed cutaneous, cardiac, liver, brain, splenic, kidney, and hematologic abnormalities. After 2 months of aggressive immune suppressive therapy she could be discharged. The treatment was tapered stepwise and discontinued at the age 1 year. At the age of 4 years she was in a favorable health condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Methylprednisolone Pulse Therapy Can Be Life-Saving in Neonatal Lupus Erythematous: A Case Report

et al. 2017

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“…The 52-kD Ro/SSA ribo-nucleoprotein is strongly linked in the autoimmune response in mothers whose children have congenital heart block. 16 These autoantibodies antagonize the serotonin-induced L-type calcium channel activation on human fetal atrial cells and trigger an inflammatory, leading to fibrosis and scarring of the atrioventricular node, sinus node, and His bundle. This explains the electrophysiological abnormalities of the cardiac rhythm disturbances, which may lead to the subsequent congestive heart failure.…”

Section: Clinical Presentationsmentioning

confidence: 99%

A retrospective study of mucocutaneous lesions of SLE patients and their systemic implications

Ponnurangam¹,

Kannan²,

Nallu³

et al. 2019

Int J Res Dermatol

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Background: SLE is a systemic disease with multiorgan involvement occuring very rarely, if so, it has a very grave prognosis if not detected early. Our study enlightens about the evolution of mucocutaneous lesions which can serve as an eye opener for early detection of systemic involvement.Methods: A descriptive study was conducted in the Department of Dermatology at a tertiary care centre from May 2017 to April 2018 retrospectively. From 15 confirmed cases of SLE a critical retrospective analysis of symptom complex evolution was done and thus a clinical correlation of evolution of mucocutaneous lesions and systemic involvement was attempted.Results: Out of the fifteen patients in our study comprising various age groups (4-51 years), mean age group was 29.76 years. 14 (93%) were female patients and 1 (6.6%) male patient. Oral ulcerations, Non-scarring alopecia and vasculitic lesions were predominant (3 patients-80%) followed by photosensitivity and cheilitis (9 patients- 60%). Systemic involvement was present in 9 (60%), out of which one (6%) patient had lupus nephritis and 3 patients (20%) had CNS lupus, 2 (13%) had chronic unilateral scleritis, 2 (13%) had interstitial lung disease, one (6%) had coronary heart disease. Mucocutaneous lesions preceded the systemic involvement in 88.8% of cases, with mean duration being 3 years (4 months – 10 years).Conclusions: Mucocutaneous lesions could serve as an eye opener for diagnosis of SLE, which is always a diagnosis made out of high degree of suspicion apart from certain mucocutaneous lesions serving as an ominous sign of system involvement in SLE.

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“…Kardiyak tutulum %20 mortal seyretmekte ve kalp bloğu olan NLE'li hastalarda %57-66 oranında "pacemaker" gerekmektedir. 2,3,6,8,9 Olgumuzun kardiyak muayenesi, ayrıca elektrokardiyografi ve ekokardiyografi incelemesi normal olarak değerlendirildi ve klinik takibe alındı. NLE'de sistemik olarak karaciğer tutulumu ve hematolojik anormallikler yaklaşık %10 oranında görülmektedir.…”

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