Poly(3-hydroxybutyrate-co-3- hydroxyvalerate) nanoparticles prepared by a miniemulsion/solvent evaporation technique: effect of phbv molar mass and concentration

Abstract

-Miniemulsification and emulsion/solvent evaporation techniques were combined to produce poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles. Those nanoparticles were prepared with different PHBV molar masses and PHBV concentrations to verify their effect on the final particle size. Nanoparticles with an average diameter of 133 nm were obtained when a low molar mass (Mw = 44,350 g/mol) polymer was used. On the other hand, when high molar mass PHBV (Mw = 369,900 g/mol) was used under the same operational conditions, nanoparticles with a 300 nm average diameter and a broader particle size distribution were formed. Results also showed that increasing the PHBV concentration led to an increase of the particle size and, when the polymer/costabilizer (PHBV/hexadecane) weight ratio was close to 1, nanocapsules (hexadecane core surrounded by a PHBV shell) were formed.

Drug encapsulated aerosolized microspheres as a biodegradable, intelligent glioma therapy

“…The presence of "flattened" microspheres seen in Figure 2.21a may indicate that some PCL microspheres being hollow, demonstrating the same sunken shape of hollow spheres reported in the literature [110][111][112]. In nanoparticle mini-emulsions, these hollow spheres arise from phase separation inside the particles between the hydrophobic material and polymer [110,113].…”

Preparation of curcumin-loaded nanoparticles and determination of the antioxidant potential of curcumin after encapsulation

“…Curcumin loaded nanoparticles were obtained using the miniemulsification-evaporation technique as described by Leimann et al [15] with some modifications. The procedure varied depending on the encapsulant used as described below.…”

Validação Do Método De Quantificação Do Óleo De Café Torrado Nanoencapsulado Em Poli(l-Ácido Lático)

“…As nanocápsulas de óleo de café torrado produzidas foram caracterizadas quanto ao Dz sendo encontrado valor igual a 290 ± 63 nm. O IPD das mesmas foi de 0,34 ± 0,16, indicando uma ampla faixa de distribuição de tamanhos, o que de acordo com Leimann et al (2013) ocorre em função da viscosidade da fase orgânica que afeta o quebramento das gotas da fase orgânica durante o processo de dispersão ou miniemulsificação. O rendimento de recuperação determinado foi de 104,5 ± 2,1 %.…”

“…Este foi utilizado como polímero encapsulante. A técnica de miniemulsificação/evaporação do solvente foi utilizada de acordo com a descrição de Leimann et al (2013). O óleo de café torrado (131 mg) foi encapsulado em PLLA (262 mg), lecitina (89,6 mg) foi utilizada como surfactante, diclorometano (11,56 g) como solvente orgânico e água destilada (22,44 g) como meio contínuo.…”