Cystatin C, kidney function, and cardiovascular risk factors in primary hypertension

Salgado, João Victor; França, Ana Karina Teixeira da Cunha; Cabral, Nayra Anielly; Lages, Joyce Santos; Ribeiro, Valdinar Sousa; Santos, Alcione Miranda dos; Salgado, Bernardete Jorge

doi:10.1590/s0104-42302013000100007

Cited by 15 publications

(4 citation statements)

References 39 publications

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“…The level of this protein was tens of times higher in CKD patients than CVD patients. The abundance of cysC, a well-known marker of renal failure [ 13 ], was increased in the plasma of CVD patients compared to HVs (fold change of 1.53 in the ELISA). However, the accumulation of cysC in the plasma of the CKD3-4 and CKD5 patients was several times greater.…”

Section: Discussionmentioning

confidence: 99%

Label-Free Quantitative Proteomics Reveals Differences in Molecular Mechanism of Atherosclerosis Related and Non-Related to Chronic Kidney Disease

Łuczak

Suszyńska-Zajczyk

Marczak

et al. 2016

IJMS

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The major cause of mortality in patients with chronic kidney disease (CKD) is atherosclerosis related to traditional and non-traditional risk factors. However, the understanding of the molecular specificity that distinguishes the risk factors for classical cardiovascular disease (CVD) and CKD-related atherosclerosis (CKD-A) is far from complete. In this study we investigated the disease-related differences in the proteomes of patients with atherosclerosis related and non-related to CKD. Plasma collected from patients in various stages of CKD, CVD patients without symptoms of kidney dysfunction, and healthy volunteers (HVs), were analyzed by a coupled label-free and mass spectrometry approach. Dysregulated proteins were confirmed by an enzyme-linked immunosorbent assay (ELISA). All proteomic data were correlated with kidney disease development and were subjected to bioinformatics analysis. One hundred sixty-two differentially expressed proteins were identified. By directly comparing the plasma proteomes from HVs, CKD, and CVD patients in one study, we demonstrated that proteins involved in inflammation, blood coagulation, oxidative stress, vascular damage, and calcification process exhibited greater alterations in patients with atherosclerosis related with CKD. These data indicate that the above nontraditional risk factors are strongly specific for CKD-A and appear to be less essential for the development of “classical” CVD.

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Section: Discussionmentioning

confidence: 99%

Label-Free Quantitative Proteomics Reveals Differences in Molecular Mechanism of Atherosclerosis Related and Non-Related to Chronic Kidney Disease

Łuczak

Suszyńska-Zajczyk

Marczak

et al. 2016

IJMS

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“…The findings of this study indicate that the GFR estimated by cystatin C has a strong association with CIMT, unlike the glomerular filtration rate estimated using the serum creatinine. Several studies have pointed out that cystatin C shows a stronger association to creatinine in the occurrence of cardiovascular events and mortality [ 37 , 38 ], because cystatin C is involved in protein catabolism, inhibiting elastolytic proteases, which are increased in degenerative and inflammatory processes, such as atherosclerosis, which may work as a direct marker of the atherogenic process [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil

et al. 2018

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Ethnicity appears to play an important role in the prevalence and severity of hypertension, renal disease, and atherosclerosis. A cross-sectional study was conducted, including 206 Afro-descendants with hypertension, living in the remaining quilombo communities. These subjects underwent a carotid intima-media thickness (CIMT) assessment. The presence of renal injury was assessed by: (1) The glomerular filtration rate (GFR) estimated by the formula CKD-EPI using creatinine and cystatin C and (2) Albuminuria (ACR ≥30 mg/g). The Poisson distribution model was set with robust variance to identify factors associated with carotid atherosclerosis. The statistical analysis was performed using the Stata 12.0 software, adopting a significance level of 5%. Most subjects were women (61.65%); the average age was 61.32 (±12.44) years. Subjects (12.62%) were identified with GFR <60 mL/min/1.73 m2 and 22.8% with albuminuria. Patients (59.22%) presented with a high CIMT. In the adjusted regression model, age ≥60 years (PR: 1.232 [CI 95%:1.091–1.390], p value = .001), ACR ≥30 mg/g (PR: 1.176 [CI 95%: 1.007–1.373], p = .040), and GFR/CKD-EPI using cystatin C (PR: 1.250 [CI 95%: 1.004–1.557], p = .045) were independently associated with carotid atherosclerosis. The occurrence of atherosclerotic lesions was high in the studied group. Age, albuminuria, and GFR (estimated by the formula CKD-EPI using cystatin C) influenced the prevalence of carotid atherosclerosis.

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“…В более ранних исследованиях установлено, что значительное повышение содержания цистатина С может быть информативно уже на ранних стадиях дисфункции почек [22]. Кроме того, данные метаанализов и других целенаправленно проведенных исследований свидетельствуют, что содержание цистатина С в плазме крови служит прогностическим фактором увеличения суммарного риска развития сердечно-сосудистых осложнений [23,24]. Это вполне согласуется с результатами нашей работы, так как в группе пациентов с ХБП и атеросклерозом сонных артерий рост уровня цистатина С сопровождался статистически значимым увеличением ИМТ, систолического и центрального АД, что соответствует также данным других исследований [25].…”

Section: Discussionunclassified

Evaluation of nephrocerebral risk with the use of cystatin C in patients with chronic kidney disease

Муркамилов¹,

Сабиров²,

Fоmin³

et al. 2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Цель исследования. Изучение роли цистатина С в формировании нефроцеребрального риска при хронической болезни почек (ХБП) на начальной стадии заболевания. Материал и методы. Обследовали 128 пациентов (63 мужчин и 65 женщин) с ХБП на додиализной стадии заболевания. Всем пациентам проведено комплексное клинико-лабораторное обследование с определением липидного состава крови, мочевой кислоты, фибриногена, кальция и цистатина С в крови с последующим расчетом скорости клубочковой фильтрации. Для оценки структурных изменений сонных артерий выполняли ультразвуковое дуплексное сканирование. В зависимости от толщины комплекса интима-медиа всю выборку разделили на группы ХБП без признаков атеросклероза (n=70) и на ХБП с атеросклерозом сонных артерий (n=58). Результаты. Пациенты c ХБП с атеросклерозом сонных артерий имели более высокие показатели индекса массы тела (p<0,05), уровня систолического (p<0,05) и центрального (p<0,05) артериального давления и содержание цистатина С в крови (p<0,05). В этой же группе отмечалось достоверное снижение концентрации холестерина липопротеинов высокой плотности (p<0,05) по сравнению с таковой у пациентов с ХБП без атеросклероза сонных артерий. На увеличение толщины комплекса интима-медиа влияли возраст пациентов и содержание цистатина С в крови (p<0,05). Достоверная прямая корреляция между содержанием цистатина С и толщиной комплекса интима-медиа, систолическим и диастолическим артериальным давлением (p<0,05) и обратная связь со скоростью клубочковой фильтрации отмечалась у больных ХБП с атеросклерозом сонных артерий. Заключение. Увеличение содержания цистатина С в плазме крови при ХБП указывает на развитие структурных изменений сонных артерий, рост уровня систолического и центрального артериального давления, снижение концентрации холестерина липопротеинов высокой плотности, которые ассоциированы с достоверным снижением скорости клубочковой фильтрации. Ключевые слова: хроническая болезнь почек, цистатин С, толщина комплекса интима-медиа, цереброваскулярные заболевания.

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Cystatin C, kidney function, and cardiovascular risk factors in primary hypertension

Abstract: Cystatin C can be used as a screening marker both for detecting mild declines of renal function and for preventing the risk of cardiovascular events in hypertensive subjects with presumably normal renal function.

Cited by 15 publications

References 39 publications

Label-Free Quantitative Proteomics Reveals Differences in Molecular Mechanism of Atherosclerosis Related and Non-Related to Chronic Kidney Disease

Label-Free Quantitative Proteomics Reveals Differences in Molecular Mechanism of Atherosclerosis Related and Non-Related to Chronic Kidney Disease

Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil

Evaluation of nephrocerebral risk with the use of cystatin C in patients with chronic kidney disease

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