Evaluation of nephrocerebral risk with the use of cystatin C in patients with chronic kidney disease

Муркамилов, И Т; Сабиров, И С; Fоmin, Victоr; Муркамилова, Ж. А.; Айтбаев, К А; Rayimzhanov, Z R

doi:10.17116/jnevro201811809110

Cited by 7 publications

(1 citation statement)

References 28 publications

(23 reference statements)

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“…The proposed article, which develops the theses of early detection of CKD using cystatin C, is a continuation of the work we began to study the relationship of cystatin C with clinical and laboratory factors associated with a decrease in GFR [12,13].…”

Section: Discussionmentioning

confidence: 99%

Cystatin C as the Predictor of Chronic Kidney Disease in Patients with Comorbid Pathology

Муркамилов

Fomin²,

Айтбаев³

et al. 2019

ASOAJ

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Purpose of the study:To study the content of cystatin C and to identify the factors reducing the glomerular filtration rate in patients with comorbid pathology.Materials and methods: 383 patients with comorbid pathology aged from 25 to 88 years (mean age 58.8±12.0 years) were examined, of whom 51.4% were men and 48.6% women. In the structure of comorbid pathology, arterial hypertension (AH) was observed in 76.5%, coronary heart disease (CHD) in 48.8%, diabetes mellitus (DM) type2 in 29.7%, obesity in 47, 5% and chronic obstructive pulmonary disease (COPD) in 28.9% of patients. The examined patients were divided into 4 groups: 1 st persons with hypertension+type2 diabetes (n = 99); 2 nd -AH + CHD (n = 138); 3 rd -AH + COPD (n = 102) and the 4 th group patients with severe comorbid pathology, i.e. AH + DM + CHD + COPD (n = 44). All patients were studied for lipid spectrum parameters [total cholesterol (cholesterol), high-density lipoprotein cholesterol (HDL cholesterol), low-density lipoprotein cholesterol (LDL cholesterol), triglycerides (TG)] and cystatin C of blood plasma. The glomerular filtration rate (GFR) was calculated according to the formula F.J. Hoek. The severity of renal dysfunction was assessed according to the recommendation of KDIGO (Kidney Disease: Improving Global Outcomes) 2012. The analysis of the prevalence of reduced GFR in patients with comorbid pathology was also carried out. Results:The presence of reduced GFR gradations of C2 and C3 "A" was detected in 46.7% and 24.8% of the examined individuals, respectively. Severe reduction in GFR was observed in 11.7% of patients. Sharply reduced GFR (C4 gradation) was significantly more frequently registered in women than in men (10.7% versus 5.0%; p <0.05). In the examined cohort, persons of middle and old age made up 36.8% and 42.2%, respectively. In patients with comorbid pathology, cases of hypercholesterolemia (41.7%), hypertriglyceridemia (45.4%) and elevated levels of LDL cholesterol (46.9%) were frequently detected, and in the 4 th group, the mean age and body mass index (BMI) were significantly higher, and cholesterol levels of HDL and GFR were significantly lower compared with other groups. In the 1st group (AH+DM type2), systolic blood pressure (SBP), total cholesterol and cystatin C plasma levels were significantly higher than in the AH+CHD, AH+COPD groups and patients with severe comorbid pathologies. Higher concentrations of LDL cholesterol were observed in patients with hypertension and COPD. In the 1 st group of patients, the GFR value closely correlated with age (r=-0.21; p=0.03), the level of SBP (r=-0.34; p=0.03), and concentration cystatin C of blood plasma (r=-0.87; p=0.01). In the 2 nd subgroup, the GFR index was associated with the level of the SBP (r=-0.32; p=0.03) and the concentration of cystatin C in the blood plasma (r=-0.86; p=0.03). In patients with AH, COPD negative association of GFR was recorded with age (r=-0.44; p=0.03), heart rate (r=-0.36; p=0.03), total cholesterol concentration (r=-0.20; p=0.04), HDL cholesterol ...

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Section: Discussionmentioning

confidence: 99%

Cystatin C as the Predictor of Chronic Kidney Disease in Patients with Comorbid Pathology

Муркамилов

Fomin²,

Айтбаев³

et al. 2019

ASOAJ

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Association of cystatin C with changes of left ventricular structure and function in individuals with different cardiovascular risk

et al. 2023

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Aim. This study aims to investigate the association of cystatin C with changes of left ventricular structure and function in individuals with different cardiovascular risk (CVR).Material and methods. 267 patients with low-moderate (group I, n=58), high (group II, n=80) and extremely high (group III, n=129) CVR were examined. The level of serum cystatin C, creatinine and blood lipid spectrum, filtration rate of the kidneys and echocardiography indicators were estimated.Results. Among all the study participants (n=267), 194 patients (72,6% of cases) had the increased level of serum cystatin C; 165 patients (61,7% of cases) showed the signs of the left ventricular hypertrophy (LVH). The increased level of serum cystatin C was observed in 51,7% of cases in group I; 75,0% — in group II and 80,6% — in group III. The values of glomerular filtration rate (GFR) calculated using the CKD-EPI and F. Hoek formula were the following: 100,2±17,0 ml/min/1,73 m2 and 84,8±15,5 ml/min/1,73 m2, p<0,05 in group I; 81,2±21,6 ml/min/1,73 m2 and 63,1±18,3 ml/min/1,73 m2, p<0,05 in group II; 63,0 (32,0;93,0) ml/min/1,73 m2 and 55,1 (22,1;70,7) ml/min/1,73 m2 — in group III. The LVH detection increased with the increase of the CVR degree (43,1% — in group I; 66,2% — in group II and 67,4% in group III). Relative wall thickness (RWT, units) increased significantly from the patients of group I (0,34±0,04 units) to the patients of group II (0,37±0,08 units) and III (0,38±0,06 units). Eccentric variant of LVH significantly prevailed in all the groups. On one side, it was found that the level of serum cystatin C was in direct correlation with left ventricular mass index (LVMI, r=0,268, p<0,05) and left ventricular RWT (r=0,190, p<0,05), and on the other side, the inverse relationship between LVMI and GFR for cystostatin C was observed (r=-0,324, p<0,05).Conclusion. The results of the study showed that the level of serum cystatin C and LVMI value significantly increase with the increase of the CVR degree. The high levels of serum cystatin C are closely associated with the increase of LVMI and the changes in the RWT value. In turn, the increase of LVMI negatively correlated with filtration rate of the kidneys in patients with different CVR. Concerning the structural changes in the left ventricle, eccentric HLV prevailed in all the three groups.

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Correlations between parameters of central hemodynamics and cytokine profile in chronic kidney disease in combination with cerebrovascular diseases

Муркамилов¹,

Сабиров²,

Фомин³

et al. 2019

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Evaluation of nephrocerebral risk with the use of cystatin C in patients with chronic kidney disease

Cited by 7 publications

References 28 publications

Cystatin C as the Predictor of Chronic Kidney Disease in Patients with Comorbid Pathology

Cystatin C as the Predictor of Chronic Kidney Disease in Patients with Comorbid Pathology

Association of cystatin C with changes of left ventricular structure and function in individuals with different cardiovascular risk

Correlations between parameters of central hemodynamics and cytokine profile in chronic kidney disease in combination with cerebrovascular diseases

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