Teratoma imaturo ovariano bilateral: relato de caso em jovem de 12 anos

Barbosa, Lyliana Coutinho Resende; Francisco, A.M.C.; Archângelo, Silvânia de Cássia Vieira; Soares, Fabíola Campos Moreira; Ferreira, Maria Cláudia Tessari; Maia, Renata Leme

doi:10.1590/s0104-42302012000200007

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Cocaine is an alkaloid extracted from Erythroxylon coca and Erythroxylon novogranatense , two plant species that grow mainly in South America and whose use has been reported for over 5,000 years 1. However, over the last 30 years, abuse of and dependence on cocaine and its smoked form, known as crack, emerged as a major public health problem in many countries 2. Brazil is one of the greatest consumer markets for cocaine worldwide (3.2 million people), and the world’s largest consumer of crack (1.8 million people) 3,4…”

Section: Introductionmentioning

confidence: 99%

Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents

Camilo

Maschietto

Vieira

et al. 2019

Braz. J. Psychiatry

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Objective:Cocaine use disorders (CUDs) represent a major public health problem in many countries. To better understand the interaction between the environmental modulations and phenotype, the aim of the present study was to investigate the DNA methylation pattern of CUD patients, who had concomitant cocaine and crack dependence, and healthy controls.Methods:We studied DNA methylation profiles in the peripheral blood of 23 CUD patients and 24 healthy control subjects using the Illumina Infinium HumanMethylation450 BeadChip arrays.Results:Comparison between CUD patients and controls revealed 186 differentially methylated positions (DMPs; adjusted p-value [adjP] < 10-5) related to 152 genes, with a subset of CpGs confirmed by pyrosequencing. DNA methylation patterns discriminated CUD patients and control groups. A gene network approach showed that the EHMT1, EHMT2, MAPK1, MAPK3, MAP2K1, and HDAC5 genes, which are involved in transcription and chromatin regulation cellular signaling pathways, were also associated with cocaine dependence.Conclusion:The investigation of DNA methylation patterns may contribute to a better understanding of the biological mechanisms involved in CUD.

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Section: Introductionmentioning

confidence: 99%

Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents

Camilo

Maschietto

Vieira

et al. 2019

Braz. J. Psychiatry

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“…If there is not adequate monitoring, as well as therapeutic management of these manifestations, users eventually return to the use of crack [4]. …”

Section: Introductionmentioning

confidence: 99%

Anxiolytic Effect of Citrus aurantium L. in Crack Users

Neto

Braga

Alves

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The objective of this study was to investigate the anxiolytic effects of the essential oil (EO) of Citrus aurantium L. in patients experiencing crack withdrawal. This was developed with internal users in therapeutic communities in Paraíba, Brazil. The test population consisted of 51 volunteers, subdivided into three groups. To elicit anxiety, the Simulated Public Speaking (SPS) method was used. Physiological measures were assessed at specific phases during the experiment using appropriate equipment. Psychological measures of anxiety were assessed using the Trait-State Anxiety Inventory (IDATE) and the Analog Smoke Scale (HAS). EO was administered by nebulization. The experiment was developed in individual sessions and consolidated to four phases. The results demonstrated that the test subjects in the groups that were given the EO maintained controlled anxiety levels during SPS, when compared to the Control Group (no treatment). Subjects who used the EO also maintained levels of “discomfort” and “cognitive impairment” during SPS. It was concluded that individuals who are experiencing internal crack cocaine withdrawal present high anxiety traits and that nebulization of the EO of Citrus aurantium L. provided an acute anxiolytic effect in crack cocaine users exposed to SPS.

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Teratoma imaturo ovariano bilateral: relato de caso em jovem de 12 anos

Cited by 2 publications

References 14 publications

Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents

Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents

Anxiolytic Effect of Citrus aurantium L. in Crack Users

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