Deficiência androgênica na mulher

Abstract

The evidence suggest that androgen deficiency in women induces sexual dysfunction as its main clinical manifestation, in particular reduced libido. However, other factors may be involved in the genesis of this disease, such as interpersonal relationships, social stressors, physical inactivity and the partner. The prevalence of sexual problems among women ranges from 9 to 43% and, recently, many studies have reported that androgens are beneficial not only for women's sexual function, but also for mood disorders and vasomotor symptoms. This is why physicians should include androgen deficiency syndrome in their differential diagnosis, even in women with adequate estrogen levels. Our objective was to present the practical aspects of this disease, emphasizing diagnosis and focusing on treatment. This review searched PUBMED for publications from the last 51 years, up to May 2010, including consensus statements and expert opinions and identified 105 articles. We concluded that the androgen deficiency syndrome in women is overlooked in clinical practice. There is no consensus in the literature regarding diagnosis or treatment, including choice of drug, route of administration and time of application.

Role of hormones in hypoactive sexual desire disorder and current treatment

“…In addition, the principal precursor of both androstenedione and testosterone androgens is dehydroepiandrosterone (DHEA), half of which is produced in the adrenal glands and 20% is generated from the ovaries; 30% is derived from dehydroepiandrosterone sulphate (DHEAS) that circulates in the blood. During post-menopause, DHEA, which is the main source of androgens, experiences an up to 60% decline resulting in hypoandrogenism, which can affect the normal sexual response in women ( 45 ).…”

Relação da testosterona e o bem-estar na promoção do equilíbrio na saúde feminina

“…Os androgênios são esteroides C19 originários do colesterol, apresentando como principais fontes produtoras na mulher as adrenais (25%), os ovários (25%) e os tecidos periféricos, como o adiposo, muscular e cutâneo (50%), por meio de conversão periférica (Fonseca et al, 2010).…”

“…No entanto, a determinação sérica da testosterona é questionável, pois os testes de radioimunoensaios apresentam baixa especificidade e sensibilidade. Alguns autores preconizam seu uso na prática clínica, considerando testosterona livre ≤ 1/4 do valor de referência para a idade reprodutiva, sugestivo da síndrome da deficiência androgênica (Fonseca et al, 2010).…”

Correction of menopausal disorders: new possibilities of menopausal hormone therapy

“…Обладая остаточной андрогенностью, ЛНГ способствует купированию астенодепрессивного синдрома [17,29,35], облегчает состояние при сниженной работоспособности и нормализует когнитивные способности [16,[36][37][38][39]. Воздействие на когнитивную функцию было продемонстрировано на цереброкортикальной культуре нейронов 17-дневных эмбрионов крыс.…”