Efeitos da esplenectomia na peritonite causada por lesão traumática do cólon: estudo em ratos

Nassif, Luis Sérgio; Repka, João Carlos Domingues; Nassif, Ana Cláudia Thá; Filho, Alcides José Branco; Olandoski, Márcia

doi:10.1590/s0104-42302004000300032

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…The anesthetic solution was made to remain about 3 min in the cavity in order to have sufficient time to act; for aspiration it was tried to dry the cavity with gentle moving, avoiding to remove all of the solution This method was satisfactory, since no death occurred in group 4, in which the anesthetic was utilized. Further work for the study of other anesthetics at the same doses in other peritonitis models 7,29 , associated or not with other therapeutic resources, could be developed. The effect of each local anesthetic on bacteria-evoking peritonitis, on the function of organs and on the inflammatory reaction prior to and after the application of these drugs, can be the object of future studies.…”

Section: Discussionmentioning

confidence: 99%

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

et al. 2008

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PURPOSE: To study the effects of peritoneal lavage with a 2% lidocaine solution, on the survival of the rats submitted to peritonitis caused by their own feces. METHODS: Forty-eight Wistar rats, weighting between 300g and 330g (mean, 311,45 ±9,67g), were submitted to laparotomy 6 hours following induction of fecal peritonitis. Animals were randomly divided into four groups of 12 each as follows: 1- Control, no therapy; 2- Drying of the abdominal cavity; 3- Peritoneal lavage with saline and drying; 4- Peritoneal lavage with a 2% lidocaine solution and drying. Animals that died were submitted to necropsy and the time of their death recorded; survivors were killed on the post-operation 11th day and necropsied. RESULTS: Death occurred within 52 h in all animals of group 1; within 126 h in 100% of those of group 2; within 50 h in 50% of those of group 3. All animals of group 4 survived. Survival on the 11 th day was higher in groups 3 and 4 than in groups 1 and 2 (p<0.001), and higher in group 4 than in group 3 (p<0.01). CONCLUSION: Peritoneal lavage with a 2% lidocaine saline solution without adrenaline, prevented the mortality of all animals with fecal peritonitis .

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Section: Discussionmentioning

confidence: 99%

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

et al. 2008

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Splenectomy does not interfere with immune response to Leishmania major infection in mice

Maioli

Carneiro

Assis

et al. 2007

Cellular Immunology

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Spleen is one of the largest lymphoid organs in the body; it harbors immune cells including antigen presenting cells, B and T lymphocytes. It has an important role in humoral and cellular immune responses. Herein we investigated the role of spleen in the immune response to experimental Leishmania major infection. It is known that C57BL/6 mice are resistant to L. major infection whereas BALB/c mice are susceptible. Although splenectomy was associated with reduced serum levels of IFN-gamma, absence of the spleen did not change the profile of L. major infection in the resistant C57BL/6 and BALB/c susceptible mice. Both strains of mice maintained the same profile of cytokine production in regional lymph nodes after splenectomy and responded in the same way against the infection. Only splenectomized BALB/c mice had a reduction in IL-4 and IL-10 production by lymph node cells early in infection. Our data suggest that, in localized infections, regional lymph nodes may replace efficiently the immunological role of spleen in the cellular and humoral immune responses.

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Splenectomy Increases Mortality in Murine Trypanosoma cruzi Infection

et al. 2010

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The spleen is a secondary lymphoid organ that harbours a variety of cells such as T and B lymphocytes and antigen‐presenting cells important to immune response development. In this study, we evaluated the impact of spleen removal in the immune response to experimental Trypanosoma cruzi infection. C57BL/6 mice were infected with Y strain of the parasite and infection was followed daily. Mice that underwent splenectomy had fewer parasites in peripheral blood at the peak of infection; however, mortality was increased. Histological analysis of heart and liver tissues revealed an increased number of parasites and inflammatory infiltrates at these sites. Spleen removal was associated with reduction in IFN‐γ and TNF‐α production during infection as well as with a decrease in specific antibody secretion. Haematological disorders were also detected. Splenectomized mice exhibited severe anaemia and decreased bone marrow cell numbers. Our results indicate that spleen integrity is critical in T. cruzi infection for the immune response against the parasite, as well as for the control of bone marrow haematological function.

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Efeitos da esplenectomia na peritonite causada por lesão traumática do cólon: estudo em ratos

Cited by 4 publications

References 12 publications

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

Splenectomy does not interfere with immune response to Leishmania major infection in mice

Splenectomy Increases Mortality in Murine Trypanosoma cruzi Infection

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