Deficiência de IgA: avaliação clínico-laboratorial de 60 pacientes do Instituto da Criança

Grumach, Anete Sevciovic; Jacob, Cristina Miuki Abe; Pastorino, Antônio Carlos

doi:10.1590/s0104-42301998000400005

Cited by 9 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is estimated that ≈ 50% of IgA‐deficient patients are asymptomatic but may develop severe allergy at a frequency three times higher than in those who are not IgA deficient (20). In ≈ 50% of 60 symptomatic IgA‐deficient patients followed up in our Unit we have observed symptoms of allergy, mainly asthma (21). Ayres & Thompson evaluated asthmatic patients with mild, persistent asthma, or affected by infections, and detected a reduction of mean IgA and IgG 3 levels, but observed no cases of IgA deficiency (22).…”

Section: Discussionmentioning

confidence: 98%

Immunoglobulin G subclass concentrations and infections in children and adolescents with severe asthma

Lui

Oliveira

Diogo

et al. 2002

Pediatric Allergy Immunology

View full text Add to dashboard Cite

It was the aim of this study to investigate possible dysfunctions of the humoral immune system in asthmatic children with frequent respiratory infections. Forty-one severe asthmatics (7-15 years of age), classified according to the Second Brazilian Consensus in Asthma (1998), were divided into two groups: group I (n = 12) had recurrent respiratory infections; and group II (n = 29) were without recurrent respiratory infections. Immunoglobulin (Ig)G, IgA and IgM levels (nephelometry), and IgE (radioimmunoassay) and IgG subclasses (enzyme-linked immunosorbent assay), were evaluated using standard methods. Asthmatics with recurrent infections presented with worse clinical evolution, an increased number of hospital admissions, and a higher need of medication than the children without recurrent infections. There were no significant differences between the mean values of IgG, IgA or IgM levels, or IgE or IgG subclasses, in patients of both groups. A complete IgA deficiency was detected in two patients of group I (one was associated with IgG subclass deficiency). Deficiency of one or more IgG subclasses was verified in eight of 12 (66%) children from group I and in 16/29 (55%) from group II. The following deficiencies were found in both groups: IgG3 (10/41), IgG4 (three of 41), IgG2 (two of 41), IgG1 (one of 41), IgG3-IgG4 (four of 41), IgG1-IgG3 (two of 41), and IgG1-IgG3-IgG4 (one of 41). There were a higher proportion of children with low IgG4 levels in group I than in group II (p = 0.01). To conclude, IgA and IgG subclass deficiencies were detected in both severely asthmatic groups, with a predominance of IgG3 subclass deficiency. However, low IgG subclass levels appear not to be a suitable predictor of the development of infections in asthmatic children.

show abstract

Section: Discussionmentioning

confidence: 98%

Immunoglobulin G subclass concentrations and infections in children and adolescents with severe asthma

Lui

Oliveira

Diogo

et al. 2002

Pediatric Allergy Immunology

View full text Add to dashboard Cite

show abstract

“…33,34,36,41 However, there are few longitudinal studies which have assessed whether asthmatics are at a higher risk of developing sIgAD or CVID over time. A few cross-sectional studies showed that IgA levels tend to be lower or deficient among asthmatics than non-asthmatics.…”

Section: Discussionmentioning

confidence: 99%

Asthma and Risk of Selective IgA Deficiency or Common Variable Immunodeficiency: A Population-Based Case-Control Study

Urm

Yun

Fenta

et al. 2013

Mayo Clinic Proceedings

View full text Add to dashboard Cite

Objectives To determine the association between a prior history of asthma and diagnosis of sIgAD/CVID. Methods The study was designed as a population-based case-control study, which included sIgAD/CVID cases who met the PAGID/ESID diagnostic criteria from the residents of Olmsted County, MN, in January 1, 1964 through December 31, 2008. Each case had 4 age- and gender-matched controls (two from the community and two from a list of individuals who had undergone an immune work up). We ascertained asthma status by applying predetermined criteria for asthma. Results We identified 39 sIgAD/CVID cases; 26 (66.7%) had sIgAD and the remaining cases had CVID. Of the 39 cases, 51.3% were male and 97.1% were Caucasians. The mean age at the index date (time when one met the criteria) of sIgAD/CVID was 34.2 years. Of the 39 cases, 9 (23%) had a history of asthma prior to index date of sIgAD/CVID; whereas of the 156 controls, 13 (10%) had a history of asthma prior to index date (OR: 2.77, 95%CI: 1.09-7.06, P=.03). A history of asthma (before or after the index date of sIgAD/CVID) was more prevalent among sIgAD/CVID cases (31%) than matched controls (12%) (OR: 3.57, 95%CI: 1.50-8.51, P=.01). Conclusions Asthmatics are more likely to have a diagnosis of sIgAD/CVID compared to non-asthmatics. This association may potentially account for increased risks of bacterial infections among some individuals with asthma.

show abstract

“…Estudos mais recentes, contudo, consideram que uma série de fatores imunológicos ainda não compreendidos é importante para que essa relação ocorra. Além disso, cabe-nos ressaltar que vários estudos demonstram a relação da deficiência de IgA, sem associação a outras síndromes, a diversas doenças autoimunes, principalmente reumatológicas, sendo, porém, a apresentação associada à doença de Graves um evento incomum (22)(23)(24).…”

Section: Discussionunclassified

Doença de Graves e deficiência de IgA como manifestações da síndrome de deleção 22q11.2

Silva¹,

Silva²,

Melo³

et al. 2010

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

The 22q11.2 deletion syndrome (22q11.2DS) is related to a high phenotypic variability including the velocardiofacial/DiGeorge spectrum. Autoimmune, endocrine and immunodeficiency manifestations have been reportedly associated with the syndrome. The objective of this study was to report a case of 22q11.2DS associated with IgA deficiency and Graves disease and review literature in order to verify the frequency of syndrome alterations. Autoimmune disorders have been increasingly related to 22q11.2DS, and new phenotypes are being incorporated in the clinical spectrum of this syndrome. In our study we found that Graves disease in association with 22q11.2DS was reported in only sixteen patients, and fifteen cases were described in the last 13 years. Based on the incidence and on the amplitude of this recognized spectrum, we reinforce the findings of literature that Graves disease should be included on the 22q11.2DS manifestations, which would lead us to seek it with 22q11.2 deletion patients.

show abstract

Deficiência de IgA: avaliação clínico-laboratorial de 60 pacientes do Instituto da Criança

Abstract: IgA deficiency has a large clinical spectrum and early diagnosis would indicate prophylaxis for infections and allergy.

Cited by 9 publications

References 33 publications

Immunoglobulin G subclass concentrations and infections in children and adolescents with severe asthma

Immunoglobulin G subclass concentrations and infections in children and adolescents with severe asthma

Asthma and Risk of Selective IgA Deficiency or Common Variable Immunodeficiency: A Population-Based Case-Control Study

Doença de Graves e deficiência de IgA como manifestações da síndrome de deleção 22q11.2

Contact Info

Product

Resources

About