Síntese e caracterização do copolímero poli (L-co-D,L Ácido Láctico)

Motta, Adriana Cristina; Duek, Eliana A. R.

doi:10.1590/s0104-14282007000200011

Cited by 24 publications

(27 citation statements)

References 24 publications

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“…The conditions used (reaction done at 130 °C for 48 h) generated high molecular weight material (10 5 g/mol), as interest increases in biodegradable polyesters for use in biomedical applications, since it physical properties of a polymer are directly dependent on its molecular weight. The molecular structures, thermal properties, as well as the mechanical properties of material were determined using 1 H-NMR, 13 C-NMR and IR. Thermal analysis by DSC showed that the terpolymer was amorphous (Tg of ~48 °C).…”

Section: Resultsmentioning

confidence: 99%

“…Table 3 shows the 13 C-NMR signals for the individual constituents of the terpolymer compared to the corresponding values reported in the literature. The presence of signals characteristic of PLDLA and TMC indicated that the synthesis of PLDLA-TMC was successful.…”

Section: Carbon-13 Nuclear Magnetic Resonance ( 13 C-nmr)mentioning

confidence: 99%

“…The presence of signals characteristic of PLDLA and TMC indicated that the synthesis of PLDLA-TMC was successful. Figure 5 shows the 13 C-NMR spectrum of the terpolymer.…”

Section: Carbon-13 Nuclear Magnetic Resonance ( 13 C-nmr)mentioning

confidence: 99%

“…Among bioresorbable polymers of interest is the copolymer poly (L,co-D,L-lactic acid; PLDLA) that is widely used in the proportion 70:30 because of its good mechanical properties and excellent biocompatibility. This polymer has been the subject of study of this research group and its synthesis is already consolidated so that the polymer has high molecular weight [7][8][9][10][11][12][13][14] . Though PLA is limited by its inherent brittleness, its properties can be significantly enhanced and broadened by modification via copolymerization, which provides a number of advantages because the architecture and composition of the biomaterials can be tailored to control and composition of the biomaterials can be tailored to control the material properties (by anionic or coordinated polymerization) 15 .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate

Motta

Duek

2014

Mat. Res.

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Terpolymers of L-lactide, D,L-lactide and trimethylene carbonate (TMC) were synthesized via the ring-opening polymerization reaction for cyclic monomers using stannous octoate as the initiator at a ratio of ~0.05 mol% (monomers/(SnOct) 2 ). Synthesis was done at 130 °C for 48 h. The inclusion of TMC, an aliphatic elastomeric polycarbonate, alongside polymer chain segments containing L-lactide and D,L-lactide, was expected to yield a material with improved properties such as increased elongation; this would overcome the limitation of copolymers consisting entirely of lactide and D,L-lactide. The terpolymer properties were assessed by Nuclear magnetic resonance spectroscopy 1 H and 13 C NMR, infrared spectroscopy, differential scanning calorimetry and thermogravimetry, with particular attention being given to the effect of TMC on the copolymer of L-lactide-co-D,L-lactide. The mixing of these polymers resulted in material with a high molar mass (10 5 g/mol). The mechanical properties of the terpolymer were assessed using pins of this material that were tested by mechanical flexion at three points. When compared with results for the copolymer PLDLA there was a decrease in Young's modulus for the TMC-containing terpolymer.

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Section: Resultsmentioning

confidence: 99%

Section: Carbon-13 Nuclear Magnetic Resonance ( 13 C-nmr)mentioning

confidence: 99%

“…The presence of signals characteristic of PLDLA and TMC indicated that the synthesis of PLDLA-TMC was successful. Figure 5 shows the 13 C-NMR spectrum of the terpolymer.…”

Section: Carbon-13 Nuclear Magnetic Resonance ( 13 C-nmr)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate

Motta

Duek

2014

Mat. Res.

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“…PLDLA 70/30 (Mw= 180.000 g/mol) was synthesized by ring-opening copolymerization of L-lactide and D,L lactide monomers, using stannous octoate as the catalyst, essentially as described by Motta 11,12 . PLDLA scaffolds were obtained by the salt-leaching method.…”

Section: Preparation Of Pldla Membranes and Scaffoldsmentioning

confidence: 99%

Surface characterization and osteoblast-like Cells culture on collagen modified PLDLA scaffolds

et al. 2014

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Surface modification techniques based on the grafting of chemical functional groups and immobilization of bioactive molecules have been used to improve biocompatibility and clinical performance of bioabsorbable scaffolds in tissue engineering and medicine regenerative applications. This study aimed at developing and characterizing a biomimetic surface to stimulate bone regeneration by a simple and low-cost method of surface biofunctionalization of the poly (L-co-D,L lactic acid)-PLDLA scaffolds. The method was obtained by grafting reaction of carboxyl groups (-COOH) on their surface via acrylic acid (AAc) polymerization process, followed by immobilization of collagen type I (Col). Such approach resulted in a surface morphology markedly modified after treatment, with increase of pores and roughness on PLDLA-AAc surfaces and a network of fibrillar collagen deposition in nonspecific areas of PLDLA-Col surfaces. The cytocompatibility of collagen-immobilized scaffolds was significantly improved in terms of cellular adhesion, proliferation, collagen synthesis and maintenance of osteoblast-like phenotype, indicating, therefore, the fundamental role of collagen protein over the biological interactions that occur by bio-recognition mimetic mechanisms at biomaterials interface. These results indicate that the surface modification method used here may be useful as a strategy to develop biofunctional scaffolds, which provide a more successful clinical application of biomaterials in the tissue engineering field.

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Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

Leal

Almeida

Dávila

et al. 2019

J of Applied Polymer Sci

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poly(L‐co‐D,L‐lactic acid) (PLDLA) is a bioresorbable and biocompatible copolymer obtained from the combination of L‐lactic and D, L‐lactic monomers. PLDLA membranes formed by aligned fibers were prepared by AC/DC electrospinning. Solutions of 8 and 10 wt % of PLDLA were used and membranes were collected by a rotating cylindrical collector. The results showed a slight increase in the fiber diameter with the increase in the polymer concentration. Fourier transform infrared spectroscopy results showed no changes in the chemical structure. Dynamic mechanical analysis results showed an increase in the storage modulus and a decrease in glass‐transition temperature for the 10 wt % samples, which was corroborated by differential scanning calorimetry. Thermogravimetric analysis showed a slight variation of the peak degradation temperature. Nevertheless, the samples did not present solvent residues. The membranes were tested in vitro using adipose‐derived mesenchymal stem cells (ASCs). The ASCs proliferated after 1, 7, and 14 days of culture, maintaining a spindle‐like morphology, which evidences their potential for tissue engineering applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47657.

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Síntese e caracterização do copolímero poli (L-co-D,L Ácido Láctico)

Cited by 24 publications

References 24 publications

Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate

Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate

Surface characterization and osteoblast-like Cells culture on collagen modified PLDLA scaffolds

Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

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