Purificação e caracterização de quitosana comercial

Signini, Roberta; Filho, Sérgio Paulo Campana

doi:10.1590/s0104-14281998000400009

Cited by 34 publications

(33 citation statements)

References 16 publications

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“…Purification of chitosan was performed as described by Signini and Campana-Filho (1998). The polymer was suspended in acetic acid 0.5 M solution and magnetically stirred for approximately 24 hours.…”

Section: Purification Of Chitosanmentioning

confidence: 99%

“…The intrinsic viscosity was determined according to Signini and Campana-Filho (1998), by relating reduced viscosity versus chitosan at finite concentration, and extrapolating to infinite dilution. Chitosan was dissolved in a buffer solution pH 4.5 of acetic acid 0.3 M and sodium acetate 0.2 M, under constant agitation for 15 hours.…”

Section: Intrinsic Viscositymentioning

confidence: 99%

“…Purification is an important process for obtaining uniform samples, free of insoluble contaminants and completely soluble, resulting in a polymer with suitable characteristics for the intended objectives (Signini, Campana-Filho, 1998).…”

Section: Purification Of Chitosanmentioning

confidence: 99%

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Production and characterization of alginate-starch-chitosan microparticles containing stigmasterol through the external ionic gelation technique

Fujiwara

Campos

Costa

et al. 2013

Braz. J. Pharm. Sci.

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Stigmasterol -a plant sterol with several pharmacological activities -is susceptible to oxidation when exposed to air, a process enhanced by heat and humidity. In this context, microencapsulation is a way of preventing oxidation, allowing stigmasterol to be incorporated into various pharmaceutical forms while increasing its absorption. Microparticles were obtained using a blend of polymers of sodium alginate, starch and chitosan as the coating material through a one-stage process using the external gelation technique. Resultant microparticles were spherical, averaging 1.4 mm in size. Encapsulation efficiency was 90.42% and method yield 94.87%. The amount of stigmasterol in the oil recovered from microparticles was 9.97 mg/g. This technique proved feasible for the microencapsulation of stigmasterol.Uniterms: Stigmasterol/ microencapsulation. Microencapsulation. Sodium alginate/drugs coating. Chitosan/drugs coating. Starch/drugs coating. Natural polymers/drugs coating.O estigmasterol, um fitoesterol com diversas atividades farmacológicas, é suscetível à oxidação quando exposto ao ar, calor e umidade. Neste contexto, a microencapsulação é uma forma de proteção contra oxidação, permitindo a incorporação do estigmasterol em diversas formas farmacêuticas e aumentar sua absorção. As micropartículas foram obtidas por gelificação iônica externa, em uma etapa, utilizando como revestimento polímeros naturais de alginato de sódio, amido de milho e quitosana. As micropartículas apresentaram formato esférico com tamanho aproximado de 1,4 mm. O rendimento foi de 94,87% e a eficiência média de encapsulação de 90,42%. A quantidade de estigmasterol no óleo recuperado das micropartículas foi de 9,97 mg/g. O método mostrou-se viável para a microencapsulação do estigmasterol.Unitermos: Estigmasterol/microencapsulação. Microencapsulamento. Alginato de sódio/revestimento de fámacos. Quitosana/revestimento de fámacos. Amido/revestimento de fámacos. Polímeros naturais/ revestimento de fámacos.

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Section: Purification Of Chitosanmentioning

confidence: 99%

Section: Intrinsic Viscositymentioning

confidence: 99%

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Production and characterization of alginate-starch-chitosan microparticles containing stigmasterol through the external ionic gelation technique

Fujiwara

Campos

Costa

et al. 2013

Braz. J. Pharm. Sci.

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show abstract

“…A literatura descreve diversas metodologias para determinar o grau de desacetilação (GD) (SANTOS, et al, 2003;SIGNINI;FILHO, 1998 Em razão da quitosana ser higroscópica foi levado em consideração o teor de água obtido pela curva TG para a determinação da massa de biopolímero necessária para reagir estequiometricamente (1:1) com o fármaco.…”

Section: Determinação Do Grau De Desacetilação Titulação Potenciométricaunclassified

“…É um polissacarídeo de cadeia linear e catiônico em soluções ácidas (SIGNINI; FILHO, 1998, SANTOS, 2004.…”

Section: Introductionunclassified

Estudo da dissociação de ibuprofeno utilizando matrizes de quitosana e montmorilonita/quitosana

Peres¹

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Spontaneous Birefringence in Layer-by-Layer Films of Chitosan and Azo Dye Sunset Yellow

Santos¹,

Bassi²,

Misoguti³

et al. 2002

Macromol. Rapid Commun.

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Purificação e caracterização de quitosana comercial

Cited by 34 publications

References 16 publications

Production and characterization of alginate-starch-chitosan microparticles containing stigmasterol through the external ionic gelation technique

Production and characterization of alginate-starch-chitosan microparticles containing stigmasterol through the external ionic gelation technique

Estudo da dissociação de ibuprofeno utilizando matrizes de quitosana e montmorilonita/quitosana

Spontaneous Birefringence in Layer-by-Layer Films of Chitosan and Azo Dye Sunset Yellow

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