Using an experimental model for the study of therapeutic touch

Santos, Daniella Soares dos; Marta, Ilda Estefani Ribeiro; Cárnio, Evelin Capellari; Quadros, Andreza Urba de; Cunha, Thiago M.; Carvalho, Emı́lia Campos de

doi:10.1590/s0104-11692013000100021

Cited by 7 publications

(3 citation statements)

References 17 publications

(16 reference statements)

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“…At least 1 study has examined the effects of a biofield therapy (TT) on nociceptive threshold in a mouse model. 25 Studies examining inflammatory immune, neuroendocrine (eg, oxytocin, endogenous opioids), and neural activity correlates (eg, via functional magnetic resonance imaging [fMRI]) would also be useful, and these results could be compared to those found for placebo analgesia 26 , 27 to determine whether common pathways exist. Finally, given that other practitioner-assisted integrative practices (such as acupuncture) have been shown to be effective for pain, 28 the incorporation of biofield therapies into comparative effective research designs to enable direct comparison with other integrative approaches would be valuable.…”

Section: Clinical Studies Of Biofield Therapy Effectiveness: State Ofmentioning

confidence: 99%

Clinical Studies of Biofield Therapies: Summary, Methodological Challenges, and Recommendations

Jain

Hammerschlag

Mills

et al. 2015

Glob Adv Health Med

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Biofield therapies are noninvasive therapies in which the practitioner explicitly works with a client's biofield (interacting fields of energy and information that surround living systems) to stimulate healing responses in patients. While the practice of biofield therapies has existed in Eastern and Western cultures for thousands of years, empirical research on the effectiveness of biofield therapies is still relatively nascent. In this article, we provide a summary of the state of the evidence for biofield therapies for a number of different clinical conditions. We note specific methodological issues for research in biofield therapies that need to be addressed (including practitioner-based, outcomes-based, and research design considerations), as well as provide a list of suggested next steps for biofield researchers to consider.

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Section: Clinical Studies Of Biofield Therapy Effectiveness: State Ofmentioning

confidence: 99%

Clinical Studies of Biofield Therapies: Summary, Methodological Challenges, and Recommendations

Jain

Hammerschlag

Mills

et al. 2015

Glob Adv Health Med

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“…Nurses have used the HT as a complementary therapy based on the millenary technique of hand laying to treat patients with different clinical conditions (Santos et al 2013b). HT is based on the theory that affirms that if an energy field is present, balanced and flowing appropriately, the patient experiences well-being (Hover-Kramer et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Non-pharmacological interventions to manage fatigue and psychological stress in children and adolescents with cancer: an integrative review

et al. 2015

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Cancer-related fatigue (CRF) is the most stressful and prevalent symptom in paediatric oncology patients. This integrative review aimed to identify, analyse and synthesise the evidence of non-pharmacological intervention studies to manage fatigue and psychological stress in a paediatric population with cancer. Eight electronic databases were used for the search: PubMed, Web of Science, CINAHL, LILACS, EMBASE, SCOPUS, PsycINFO and the Cochrane Library. Initially, 273 articles were found; after the exclusion of repeated articles, reading of the titles, abstracts and the full articles, a final sample of nine articles was obtained. The articles were grouped into five categories: physical exercise, healing touch, music therapy, therapeutic massage, nursing interventions and health education. Among the nine studies, six showed statistical significance regarding the fatigue and/or stress levels, showing that the use of the interventions led to symptoms decrease. The most frequently tested intervention was programmed physical exercises. It is suggested that these interventions are complementary to conventional treatment and that their use can indicate an improvement in CRF and psychological stress.

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“…Due to in vitro data which suggested the anti-inflammatory potential of ICMD-01, in vivo studies were carried out in order to assess the interference of biological systems and possible changes in pharmacological activity using paw inflammation models induced by Freund's complete adjuvant (CFA). CFA is a complex consisting of a suspension of Mycobacterium tuberculosis and mineral oil which guarantees both deposition action and formation of granulomas rich in macrophages and immunocompetent cells [35][36][37].…”

Section: Biological Activitymentioning

confidence: 99%

(E)-2-Cyano-3-(1H-Indol-3-yl)-N-Phenylacrylamide, a Hybrid Compound Derived from Indomethacin and Paracetamol: Design, Synthesis and Evaluation of the Anti-Inflammatory Potential

Silva

Almeida

Silva

et al. 2020

IJMS

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The compound (E)-2-cyano-3-(1H-indol-3-yl)-N-phenylacrylamide (ICMD-01) was designed and developed based on the structures of clinically relevant drugs indomethacin and paracetamol through the molecular hybridization strategy. This derivative was obtained by an amidation reaction between substituted anilines and ethyl 2-cyanoacetate followed by a Knoevenagel-type condensation reaction with indole aldehyde that resulted in both a viable synthesis and satisfactory yield. In order to assess the immunomodulatory and anti-inflammatory activity, in vitro assays were performed in J774 macrophages, and significant inhibitions (p < 0.05) of the production of nitrite and the production of cytokines (IL-1β and TNFα) in noncytotoxic concentrations were observed. The anti-inflammatory effect was also studied via CFA-induced paw edema in vivo tests and zymosan-induced peritonitis. In the paw edema assay, ICMD01 (50 mg kg−1) showed satisfactory activity, as did the group treated with dexamethasone, reducing edema in 2–6 h. In addition, there was no significant inhibition of PGE2, IL-1β or TNFα in vivo. Moreover, in the peritonitis assay that assesses leukocyte migration, ICMD-01 exhibited promising results. Therefore, these preliminary studies demonstrate this compound to be a strong candidate for an anti-inflammatory drug together with an improved gastrointestinal safety profile when compared to the conventional anti-inflammatory drugs.

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Using an experimental model for the study of therapeutic touch

Cited by 7 publications

References 17 publications

Clinical Studies of Biofield Therapies: Summary, Methodological Challenges, and Recommendations

Clinical Studies of Biofield Therapies: Summary, Methodological Challenges, and Recommendations

Non-pharmacological interventions to manage fatigue and psychological stress in children and adolescents with cancer: an integrative review

(E)-2-Cyano-3-(1H-Indol-3-yl)-N-Phenylacrylamide, a Hybrid Compound Derived from Indomethacin and Paracetamol: Design, Synthesis and Evaluation of the Anti-Inflammatory Potential

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