Meta-análise para estimativas de correlação genética entre pesos ao nascer e desmama de bovinos

Giannotti, Juliana Di Giorgio; Packer, Irineu Umberto; Mercadante, Maria Eugênia Zerlotti

doi:10.1590/s0103-90162002000300004

Cited by 9 publications

(7 citation statements)

References 8 publications

(4 reference statements)

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“…This procedure was also adopted in other meta‐analysis studies (Giannotti et al . , ). When the homogeneity of variance was tested between clusters, after using the Ward clustering method, it was expected that there would be heterogeneity among clusters (Table ); however, it was not expected that there would be heterogeneity within clusters, because the aim of this method was to obtain the most homogeneous values within each cluster.…”

Section: Discussionmentioning

confidence: 99%

“…; Giannotti et al . , ). The aim of this study was to utilize a meta‐analysis approach to combine published heritability and genetic correlation estimates among dry matter intake (DMI), average daily gain (ADG), metabolic body weight (MBW), feed conversion ratio (FCR) and residual feed intake (RFI) to produce genetic parameters useful for genetic evaluation in the absence of sufficient data to estimate these parameters.…”

Section: Introductionmentioning

confidence: 99%

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Cluster and meta‐analyses of genetic parameters for feed intake traits in growing beef cattle

Diaz

Crews

Enns

2013

J Animal Breeding Genetics

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A data set based on 50 studies including feed intake and utilization traits was used to perform a meta-analysis to obtain pooled estimates using the variance between studies of genetic parameters for average daily gain (ADG); residual feed intake (RFI); metabolic body weight (MBW); feed conversion ratio (FCR); and daily dry matter intake (DMI) in beef cattle. The total data set included 128 heritability and 122 genetic correlation estimates published in the literature from 1961 to 2012. The meta-analysis was performed using a random effects model where the restricted maximum likelihood estimator was used to evaluate variances among clusters. Also, a meta-analysis using the method of cluster analysis was used to group the heritability estimates. Two clusters were obtained for each trait by different variables. It was observed, for all traits, that the heterogeneity of variance was significant between clusters and studies for genetic correlation estimates. The pooled estimates, adding the variance between clusters, for direct heritability estimates for ADG, DMI, RFI, MBW and FCR were 0.32 ± 0.04, 0.39 ± 0.03, 0.31 ± 0.02, 0.31 ± 0.03 and 0.26 ± 0.03, respectively. Pooled genetic correlation estimates ranged from -0.15 to 0.67 among ADG, DMI, RFI, MBW and FCR. These pooled estimates of genetic parameters could be used to solve genetic prediction equations in populations where data is insufficient for variance component estimation. Cluster analysis is recommended as a statistical procedure to combine results from different studies to account for heterogeneity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cluster and meta‐analyses of genetic parameters for feed intake traits in growing beef cattle

Diaz

Crews

Enns

2013

J Animal Breeding Genetics

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“…Thus, combining results from different primary studies and their use in recent years, added significantly to the area of health by the high degree of recommendation associated with levels of evidence that it translates (63,67) . The main steps of a meta-analysis are: (1) the literature, (2) the transformation of the results of each study group on a common measure, (3) checking the homogeneity of the results, (4) modeling variation between studies, and finally (5) the sensitivity analysis (20) .…”

Section: Methodsmentioning

confidence: 99%

Genotype Association Gstm1 Null and Gastric Cancer: Evidence-Based Meta-Analysis

Ribeiro

Nascimento

Silva

2017

Arq. Gastroenterol.

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-Background -Gastric cancer is the fourth most common cancer in men and the sixth among women, except for non-melanoma skin tumors, in Brazil. Epidemiological evidences reveal the multifactorial etiology of this cancer, highlighting risk factors such as: infection by the bacterium Helicobacter pylori, advanced age, smoking, chronic alcohol abuse, eating habits and genetic polymorphisms. Considering the context of genetic polymorphisms, there is the absence of the GSTM1 gene. The lack of GSTM1 function to detoxify xenobiotics and promote defense against oxidative stress leads to increased DNA damage, promoting gastric carcinogenesis. This process is multifactorial and the development of gastric cancer results from a complex interaction of these variables. Objective -The aim of this study was to investigate the association of GSTM1 null polymorphism in the pathogenesis of gastric cancer. Methods -A meta-analysis was conducted from 70 articles collected in SciELO and PubMed databases, between September 2015 and July 2016. In order to evaluate a possible association, we used the odds ratio (OR) and confidence interval of 95% (CI 95%). To assess the heterogeneity of the studies was used the chi-square test. Statistical analysis was performed using the BioEstat ® 5.3. Results -This study included 70 studies of case-control, including 28,549 individuals, which were assessed for the null polymorphism of the GSTM1 gene, and of which 11,208 (39.26%) were cases and 17,341 (60.74%) were controls. The final analysis showed that the presence of the GSTM1 gene acts as a protective factor against the development of gastric cancer (OR=0.788; 95%CI 0.725-0.857; P<0.0001). Positive statistical association was found in Asia (OR=0.736; P<0.0001) and Eurasia (OR=0.671; P=0.05). However, statistically significant data was not obtained in Europe (OR=1.033; 95%CI 0.873-1.222; P=0.705) and America (OR=0.866; 95%CI 0.549-1.364; P=0.534). Therefore, the results can not be deduced around the world. Conclusion -This meta-analysis concluded that the presence of the GSTM1 gene is a protector for the emergence of gastric cancer, especially in Asian countries, but this result was not found in Europe and America.

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“…A meta-análise pode ser definida como um procedimento estatístico que consiste de uma revisão quantitativa e resumida de resultados de estudos distintos, mas relacionados (GIANNOTTI; PACKER; MERCADANTE, 2005b). Os métodos estatísticos empregados na meta-análise asseguram a obtenção de uma estimativa combinada e precisa, sobretudo em virtude do aumento do número de observações e, consequentemente, do poder estatístico e da possibilidade de examinar a variabilidade entre os estudos, o que não é possível quando se realiza apenas uma média dos resultados publicados (FAGARD;STAESSEN;THIJS, 1996).…”

Section: Introductionunclassified

“…De acordo com Lovatto et al (2007) no domínio agrícola, o número de meta-análises publicadas tem aumentado nos últimos anos (GIANNOTTI; PACKER; MERCADANTE, 2002;SAUVANT, 2002;MARTIN;SAUVANT, 2002;OFFNER;BACH;SAUVANT, 2003;EUGÈNE;ARCHIMEDE;SAUVANT, 2004;GIANNOTTI et al, 2005a;MERCADANTE, 2005b;HAUPTLI;BERGMANN;GONZÁLEZ;ZARBIN, 2009) sinalizando que esse procedimento possa se tornar rotina nesse campo da ciência. Contudo, para o setor de grandes culturas em especial para a cultura do café (C. canephora) não há trabalhos envolvendo meta-análise.…”

Section: Introductionunclassified

Meta-análise para estimativas de herdabilidade de características do desenvolvimento e produção do Coffea canephora Pierre

et al. 2012

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ResumoEstimativas de herdabilidade de características relacionadas ao desenvolvimento e produção de cafeeiros (C. canephora) são informações muito utilizadas em programas de melhoramento genético, no entanto, em virtude do grande número de trabalhos científicos publicados nos últimos anos observamse conclusões destoantes. Assim, sumarizar essas informações tornou-se uma necessidade. Neste contexto, uma meta-análise foi conduzida com o objetivo de resumir as estimativas para a herdabilidade das características relacionadas ao desenvolvimento e produção de C. canephora. Foram avaliadas estimativas de herdabilidade referentes às seguintes características: altura da planta, diâmetro do caule, tamanho dos frutos, ciclo de maturação, produção de grãos (kg ha -1 ), uniformidade de maturação, percentual de grãos chatos, percentual de grãos chochos, percentual de grãos moca, percentagem de umidade do grão na colheita, relação café cereja e café coco, relação café cereja e café beneficiado, relação café coco e café beneficiado, percentagem de peneira média e rendimento. Os dados referentes às estimativas de herdabilidade são provenientes de artigos científicos publicados em revistas nacionais e internacionais, anais de congressos, teses e dissertações. A maioria das características avaliadas, com exceção do diâmetro do caule e do rendimento, são altamente herdáveis, refletindo a grande variedade genética dos cafeeiros, e possibilitando com que ganhos genéticos satisfatórios possam ser atingidos em programas de melhoramento em que essas características são avaliadas. O uso da técnica de metaanálise mostra-se eficiente para sintetizar os resultados dos estudos de estimativa de herdabilidade obtidos em experimentos de avaliação das características relacionadas ao desenvolvimento e a produção de grãos em cafeeiros da espécie C. canephora. Palavras-chave: Estimativas combinadas, parâmetros genéticos, sistematização AbstractHeritability of estimates related to development and production traits of coffee (C. canephora) are widely used informations in genetic improvement programs. However, because of the great number of scientific papers published in the recent years, conflicting conclusions are observed. Thus, to summarize such information has become a necessity. In this context, a meta-analysis was conducted with the objective of summarizing the heritability estimates of traits related to the development and production of C. canephora. Heritability estimates were appraised regarding the following traits: plant height,

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Meta-análise para estimativas de correlação genética entre pesos ao nascer e desmama de bovinos

Cited by 9 publications

References 8 publications

Cluster and meta‐analyses of genetic parameters for feed intake traits in growing beef cattle

Cluster and meta‐analyses of genetic parameters for feed intake traits in growing beef cattle

Genotype Association Gstm1 Null and Gastric Cancer: Evidence-Based Meta-Analysis

Meta-análise para estimativas de herdabilidade de características do desenvolvimento e produção do Coffea canephora Pierre

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