Produtividade de ratos Wistar em diferentes sistemas de acasalamento

Mattaraia, Vânia Gomes de Moura; Moura, Ana Silvia Alves Meira Tavares

doi:10.1590/s0103-84782012000800026

Cited by 9 publications

(13 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This procedure is recommended for rat reproduction because it maintains animal welfare, respects female physiology, allows matrices to rest during pregnancy and lactation, and decreases maternal and offspring mortality 5 Our results showed that BM vs. length and BM vs. length of the tibia displayed a simple allometric pattern represented by straight lines with very definite turning points that depicted changes in growth rates. Further, we found a direct correlation between BM and another important parameter of maturity, which is animal length, expressed by the muzzle-tail distance.…”

mentioning

confidence: 66%

“…After reaching the reproductive age (13 weeks) 5 , matrices and breeding males were mated. The animals were maintained under temporary polygamous mating conditions with two females per male for up to two weeks.…”

Section: Mating and Pregnancymentioning

confidence: 99%

“…Copulation was confirmed by daily checking for the presence of sperm in the vaginal fluid collected with a cotton swab moistened with distilled water and introduced into the vagina. This material was smeared on a slide, without staining, and examined under a microscope to check for the presence of spermatozoa 5 . In positive cases, pregnancy was assumed, and the female was transferred to an individual cage.…”

Section: Mating and Pregnancymentioning

confidence: 99%

“…The Wistar rat is an attractive animal model for both surgical and clinical research because of the good correspondence between rat and human anatomy, physiology, and behavior 4 . Moreover, the small size, short life cycle, and low breeding cost are additional advantages of this laboratory animal 5 . Usually, BM is the most used parameter to confirm animal development and maturity, and it is adequate for most research purposes 1 .…”

Section: Introductionmentioning

confidence: 99%

“…In addition, our findings are important when biomechanics of the bone limbs are used as a method of investigation because extrinsic biophysical processes module skeletal morphogenesis 13,14 , which means that heavier animals may have stronger bones. Changes in growth rates correspond to animal-specific development and maturation stages as well as correspond to rat puberty/sexual maturity in the final stage 5 .…”

mentioning

confidence: 99%

See 4 more Smart Citations

Allometric relationships among body mass, MUZZLE-tail length, and tibia length during the growth of Wistar rats1

et al. 2015

View full text Add to dashboard Cite

PURPOSE:To investigate allometric relationships among body mass (BM), muzzle-tail length (MTL), and tibia length (TL) in Wistar rats and establish their growth rate change parameters. METHODS:Eighteen male and 18 female Wistar rats were studied from the 3rd to the 21st week of age. BM, MTL, and TL were measured daily, and relative growth was compared using allometry. RESULTS:A positive correlation between BM and MTL (p<0.05) and BM and TL (p<0.05) was observed. Males and females showed comparable curves; however, females had turning points at a younger age. The allometric relationship between BM and MTL presented a regular increase until reaching a mass of 351 g (males) and 405 g (females). BM and TL showed an initial increase until 185 g (males)and 182 g (females), and then reached a plateau that finished at 412 g (males) and 334 g (females), to display another increase. CONCLUSIONS:The allometric relationship of body mass with animal length and tibia length was comparable for male and female rats, with female rats maturing earlier. Animal longitudinal growth occurred in a single stage. In contrast, tibia length depicted two stages of accelerated growth with an intermediate period of deceleration.

show abstract

mentioning

confidence: 66%

Section: Mating and Pregnancymentioning

confidence: 99%

Section: Mating and Pregnancymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Allometric relationships among body mass, MUZZLE-tail length, and tibia length during the growth of Wistar rats1

et al. 2015

View full text Add to dashboard Cite

show abstract

Chronic leucine supplementation does not prevent the obesity and metabolic abnormalities induced by monosodium glutamate

Ceglarek

Coelho

et al. 2020

Clinical Nutrition Experimental

View full text Add to dashboard Cite

A new mixed model of periodontitis‐induced preeclampsia: A pilot study

Mata

Nobre

Silva

et al. 2021

J of Periodontal Research

View full text Add to dashboard Cite

Objectives/Background: Recent studies have shown that periodontal disease is strongly related to gestational complications such as preeclampsia (PE). PE is responsible for 42% of maternal deaths worldwide and kills approximately 76 000 women a year. In addition, children born under PE conditions are at increased risk of hospitalization due to metabolic disorders, epilepsy, and other complications. Numerous reviews and clinical studies on PE have been published, but the mechanisms underlying the relationship between periodontal disease and PE and the way periodontopathogens alter vascular response in pregnant women remain unclear.Methods: This study aims to verify whether periodontal disease induces PE by using the association of two periodontitis (PD) models: ligature and oral Porphyromonas gingivalis (P. gingivalis) W83 inoculation in Wistar rats. At gestational day 5, the ligature was placed on each mandibular first molar, which was followed by daily oral P. gingivalis inoculation for 15 days. At gestational day 19, urine was collected, and invasive arterial pressure was measured. The animals were euthanized, and plasma and tissues were collected.Results: After 15 days of the association of ligature and P. gingivalis inoculation, the animals presented the characteristic symptoms of PE: altered blood pressure, proteinuria, and change in litter size (number of pups) and pup weight when compared to the control group (p < .005). The PE animals also presented greater bone porosity, trabecular separation, and reduced bone volume in the hemimandibles, as well as altered inflammatory response. The level of cytokine IL-6 was higher in the PE group than in the control group (p < .005). Conclusion:The association of two PD models effectively induced PE. To our knowledge, this is the first study on the oral use of P. gingivalis for PE induction. Our results support the importance of PD as a possible cause for PE development, opening an | 727 MATA eT Al.

show abstract

Produtividade de ratos Wistar em diferentes sistemas de acasalamento

Abstract: II Produtividade de ratos

Cited by 9 publications

References 5 publications

Allometric relationships among body mass, MUZZLE-tail length, and tibia length during the growth of Wistar rats1

Allometric relationships among body mass, MUZZLE-tail length, and tibia length during the growth of Wistar rats1

Chronic leucine supplementation does not prevent the obesity and metabolic abnormalities induced by monosodium glutamate

A new mixed model of periodontitis‐induced preeclampsia: A pilot study

Contact Info

Product

Resources

About