Influence of acepromazine on the cardiovascular actions of dobutamine in isoflurane-anesthetized horses

Monteiro, Eduardo Raposo; Souza, Juliano Ferreira Fernandes de; Baiotto, Gustavo Cancian; Figueiró, Giuliano Moraes; Rangel, Júlia da Penha Piccoli; Coelho, Clarisse Simões

doi:10.1590/s0103-84782011005000018

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Their cardiovascular effects vary among the different sedatives; the most common changes observed for acepromazine include a decrease in arterial blood pressure as a consequence of blockade of alpha-1 (a1) adrenergic receptors, leading to vasodilation (Ludders et al 1983), which becomes more intense during inhalant anesthesia (Grasso 2015). After premedication with acepromazine, dogs require higher doses of dopamine to increase pressures (Monteiro et al 2007), and the effects of a bolus of dextran or lactated ringer's and an ephedrine CRI were minimized by acepromazine in dogs (Sinclair & Dyson 2000), whereas it didn't influence the rate of dobutamine to keep normal pressures in horses (Monteiro et al 2011). It produces sedation through inhibition of central dopaminergic receptors, mainly at the D2 subtype, which are pre-and postsynaptic G-protein coupled receptors that when blocked decrease the calcium and potassium conductance.…”

Section: Sedatives and Tranquilizers In Small Animalsmentioning

confidence: 99%

Use of intravenous lidocaine to treat dexmedetomidine-induced bradycardia in sedated and anesthetized dogs

Tisotti

Valverde

Hopkins

et al. 2021

Veterinary Anaesthesia and Analgesia

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This thesis evaluated the use of intravenous lidocaine to treat the bradycardia associated with the administration of the sedative dexmedetomidine in canine anesthetic protocols. Research Beagle dogs were assigned to three different groups in a randomized crossover design that involved the administration of intravenous dexmedetomidine in different modalities of the anesthetic protocol. In two groups, dexmedetomidine was administered to dogs while awake and in the third group while anesthetized with isoflurane.After receiving dexmedetomidine, dogs were given intravenous lidocaine as a bolus 30 minutes later, followed by a second bolus and a constant rate infusion 20 minutes after the first bolus, in one of the awake groups and the anesthetized group. The other awake group received the lidocaine bolus and constant rate infusion 5 minutes after the dexmedetomidine.Intravenous lidocaine increased heart rate in awake and anesthetized dogs pretreated with intravenous dexmedetomidine. Additional benefits from lidocaine administration included an increase in cardiac index and a decrease in systemic vascular resistance.iii DEDICATIONIn Memoriam of my grandparents Ieda Hainzenreder and João de Mesquita.Foremost, I would like to thank my supervisor, Dr. Alexander Valverde, for opening the doors for me, for being resolute, tireless and for his guidance during my program. I would also like to thank all the anesthesia faculties I had the opportunity to work with and absorb some of their knowledge, but specially to Drs. Andrea Sanchez, Carolyn Kerr and Melissa Sinclair for the personal and professional support along these three years.

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Section: Sedatives and Tranquilizers In Small Animalsmentioning

confidence: 99%

Use of intravenous lidocaine to treat dexmedetomidine-induced bradycardia in sedated and anesthetized dogs

Tisotti

Valverde

Hopkins

et al. 2021

Veterinary Anaesthesia and Analgesia

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Intra-operative hypotension in anaesthetised horses

Loomes¹

2023

UK-Vet Equine

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The prompt and effective treatment of hypotension is important in order to avoid its negative consequences, but the management of hypotension may not always be straight forward. Treatment options may include reducing delivered volatile agent concentration, optimising circulating volume and administering positive inotropes or vasopressor agents. In order to approach treatment in the most effective way, it is important to address the underlying cause of or the most significant factor which may be contributing to suboptimal arterial blood pressure. This article summarises the causes of hypotension and various approaches to management and treatment.

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Effects of dobutamine hydrochloride on cardiovascular function in horses anesthetized with isoflurane with or without acepromazine maleate premedication

Schier

Raisis

Secombe

et al. 2016

ajvr

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OBJECTIVE To determine the effects of acepromazine maleate premedication on cardiovascular function before and after infusion of dobutamine hydrochloride for 30 minutes in isoflurane-anesthetized horses. ANIMALS 6 healthy adult horses. PROCEDURES Each horse was anesthetized once following premedication with acepromazine (0.02 mg/kg, IV) administered 30 minutes prior to anesthetic induction (ACP+ treatment) and once without premedication (ACP- treatment). Anesthesia was induced with IV administration of xylazine hydrochloride (0.8 mg/kg), ketamine hydrochloride (2.2 mg/kg), and diazepam (0.08 mg/kg). Horses were positioned in right lateral recumbency, and anesthesia was maintained via inhalation of isoflurane delivered in oxygen. End-tidal isoflurane concentration was adjusted to achieve a target mean arterial blood pressure of 60 mm Hg (interquartile range [25th to 75th percentile], 57 to 63 mm Hg) for at least 15 minutes. Cardiac index, oxygen delivery index, and femoral arterial blood flow indices were determined 60 minutes after anesthetic induction (baseline). Dobutamine was then infused to achieve a target mean arterial blood pressure of 80 mm Hg (interquartile range, 76 to 80 mm Hg). Data collection was repeated 30 minutes after the start of dobutamine infusion for comparison with baseline values. RESULTS Complete data sets were available from 5 of the 6 horses. Dobutamine administration resulted in significant increases in oxygen delivery and femoral arterial blood flow indices but no significant change in cardiac index for each treatment. However, at baseline or 30 minutes after the start of dobutamine infusion, findings for the ACP+ and ACP- treatments did not differ. CONCLUSIONS AND CLINICAL RELEVANCE In isoflurane-anesthetized horses, dobutamine administration increased oxygen delivery and femoral arterial blood flow indices, but these changes were unaffected by premedication with acepromazine.

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Influence of acepromazine on the cardiovascular actions of dobutamine in isoflurane-anesthetized horses

Abstract: The influence of acepromazine (ACP) on the effectiveness of dobutamine (DBT) in increasing blood pressure during isoflurane (ISO) anesthesia was evaluated in six horses

Cited by 3 publications

References 14 publications

Use of intravenous lidocaine to treat dexmedetomidine-induced bradycardia in sedated and anesthetized dogs

Use of intravenous lidocaine to treat dexmedetomidine-induced bradycardia in sedated and anesthetized dogs

Intra-operative hypotension in anaesthetised horses

Effects of dobutamine hydrochloride on cardiovascular function in horses anesthetized with isoflurane with or without acepromazine maleate premedication

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