Caracterização histomorfológica da atrofia inflamatória proliferativa na próstata canina

Toledo, Denise Caroline; Faleiro, Mariana Batista Rodrigues; Rodrigues, Marcela Marcondes Pinto; Santis, Giovana Wingeter Di; Amorim, Renée Laufer; Moura, Veridiana Maria Brianezi Dignani de

doi:10.1590/s0103-84782010000600021

Cited by 12 publications

(12 citation statements)

References 8 publications

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“…Prostatic atrophy can occur in response to changes in androgen production or due to the presence of inflammation directly affecting the glandular epithelium (FOSTER, 2012). According to Toledo et al (2010), inflammation, particularly the mononuclear type (lymphocytes, macrophages and occasional plasma cells), in the interstitial region of tubule-alveolar segments influences the occurrence of atrophy in the glandular epithelium (Proliferative Inflammatory Atrophy -PIA). In our study, no information was available regarding the age of the dogs that were used.…”

Section: Discussionmentioning

confidence: 99%

Histopathological alterations in the reproductive tract of male dogs with Canine Visceral Leishmaniasis

Barros

Benites

Mateus

et al. 2019

SCA

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Dogs are considered the main domestic host of Leishmania infantum. The transmission between vertebrate hosts normally occurs during blood feeding of Lutzomyia sp., a genus of phlebotomine sand flies. However, other forms of transmission without a vector have been reported. Presence of amastigotes of Leishmania sp. in different organs can cause several pathologies depending on the immune status of the host and the parasite load. The aim of this study was to evaluate histopathological changes in the reproductive tract of male dogs. Samples of testes, epididymis, and prostate gland were collected from 70 animals that were grouped according to serology test results for visceral leishmaniasis and clinical symptoms. Three experimental groups were formed based on serological results and clinical presentation: asymptomatic, symptomatic and control. Prostatic changes were seen regardless of the serological results; however, the changes were more severe in symptomatic animals. In the testes and epididymis, lesions such as interstitial infiltrate, degeneration, and fibrosis were seen more frequently and were more severe in positive animals when compared to the control group. These results demonstrate that dogs infected with Leishmania sp. can develop nonspecific changes in the reproductive tract, which are more severe in symptomatic animals. ResumoOs cães são considerados os principais hospedeiros domésticos de Leishmania infantum. A transmissão entre hospedeiros vertebrados normalmente ocorre durante o repasto sanguíneo de Lutzomyia sp., gênero de flebotomíneo. Entretanto, outras formas de transmissão sem a presença do vetor têm sido relatadas. A presença de amastigotas de Leishmania sp. em diferentes órgãos pode causar diversas patologias de acordo com o status imune do hospedeiro e a carga parasitária. O objetivo deste trabalho foi avaliar as alterações histopatológicas no trato reprodutivo de cães machos. Amostras de testículo, epidídimo e próstata foram coletadas de 70 animais, os quais foram agrupados conforme o resultado da sorologia para leishmaniose visceral e os sinais clínicos. Três grupos experimentais foram formados baseados nos resultados sorológicos e manifestações clínicas: assintomático, sintomático e controle. Alterações prostáticas foram observadas independentemente dos resultados sorológicos; entretanto, foram mais acentuadas nos animais sintomáticos. Nos testículos e epidídimos, lesões como infiltrado intersticial, degeneração e fibrose foram observadas mais frequentemente e de forma mais severa nos animais positivos quando comparados ao grupo controle. Estes resultados demonstram que cães infectados com Leishmania sp. podem desenvolver alterações não específicas no trato reprodutivo, as quais são mais severas nos animais sintomáticos. Palavras-chave: Amastigotas. Epidídimo. Leishmania sp. Próstata. Testículo.

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Section: Discussionmentioning

confidence: 99%

Histopathological alterations in the reproductive tract of male dogs with Canine Visceral Leishmaniasis

Barros

Benites

Mateus

et al. 2019

SCA

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“…Histomorphological evaluation of 70 canine prostate samples in HE staining was carried out to identify normal prostatic tissue, and those with PIA (TOLEDO et al, 2010), and PC (LAI et al, 2008). Prostatic samples were obtained from no neutered, mixed-breed, adult dogs, and all normal prostatic tissues were harvested from dogs with nonmalignant lesions in the gland at microscopy screening.…”

Section: Methodsmentioning

confidence: 99%

“…The proliferative inflammatory atrophy (PIA) is a dysplastic change that was first described in the study of the human prostate, and was considered a potentially premalignant lesion (PUTZI & DE MARZO, 2000;WANG et al, 2009). In dog prostate, TOLEDO et al (2010) have described the histological aspects of PIA.…”

Section: Introductionmentioning

confidence: 99%

Expression of EGF receptors in canine prostate with proliferative inflammatory atrophy and carcinoma

Faleiro¹,

Cintra

Jesuino

et al. 2017

Cienc. Rural

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Gene expression of ErbB1 and ErbB2, and immunostaining of EGFR (Her1) and Her2 (c-erbB-2) were evaluated in this study to ascertain whether these receptors are involved in the evolution of canine premalignant and malignant prostatic lesions, as proliferative inflammatory atrophy (PIA) and prostatic carcinoma (PC). With regards to the intensity of EGFR immunostaining, there was no difference between normal prostatic tissue and tissues with PIA or PC. In relation to Her2 immunostaining, there were differences between normal prostatic tissue and those with PIA and PC, as also differences between prostates with PIA and PC. There was no correlation between EGFR and Her2 immunostaining. ErbB1 gene product was detected in two normal tissue samples, in one with PIA, and in all samples with PC. ErbB2 mRNA was recorded in two canine samples with PIA, in all with PC, but was not detected in normal prostatic tissue. It was concluded that EGFR and Her2 play roles in canine PIA and PC, suggesting that those receptors may be involved in canine prostatic carcinogenesis.

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“…Three-µm-sections were obtained from formalinfixed-paraffin-embedded (FFPE) tissue blocks and stained with hematoxylin and eosin (HE) for microscopic examination. Histomorphological evaluation included normal prostates and with BHP (LEAV et at., 2001), PIA (TOLEDO et al, 2010), PIN (BOSTWICK 1995), andPC (VASTO, 2008). All histological slides were examined by three investigators.…”

Section: Methodsmentioning

confidence: 99%

“…Also, RODRIGUES et al (2010) mentioned PIA in canine prostate and TOLEDO et al (2010) described it histological aspects in the gland of dogs.…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinases 2 and 9 expression in canine normal prostate and with proliferative disorders

et al. 2013

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In this study the expression of metalloproteinases 2 (MMP-2) and 9 (MMP-9) in canine normal prostates and with proliferative disorders was evaluated to verify the role of these enzymes in extracellular matrix remodeling (ECM) and in the tissue invasion process. A total of 355 prostatic samples were obtained, from which 36 (10.1%) were normal prostates, 46 (13.0%) with benign prostatic hyperplasia (BPH), 128 (36.1%) with proliferative inflammatory atrophy (PIA), 74 (20.8%) with prostatic intraepithelial neoplasia (PIN), and 71 (20.0%) with prostatic carcinoma (PC). Difference in cytoplasmic immunohistochemical staining of MMP-2 and MMP-9 between acinar epithelium and periacinar stroma was found regarding the different diagnosis. The correlation between MMP-2 and MMP-9 expression in relation to the number of labeled cells in acinar epithelium and periacinar stroma, as well as to the staining intensity in the periacinar stromal cells was evidenced in canine prostates with PIA. In conclusion, MMP-2 and MMP-9 expression has a variation in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in those with PIA, PIN and PC. Moreover, the inflammatory microenvironment of the PIA has influence in the activity of both enzymes.

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Caracterização histomorfológica da atrofia inflamatória proliferativa na próstata canina

Abstract: RESUMO A atrofia inflamatória proliferativa (PIA) é uma lesão prostática pré-maligna de grande ocorrência na próstata humana e, mais recentemente, também observada em cães. Esta pesquisa teve por objetivo verificar os aspectos

Cited by 12 publications

References 8 publications

Histopathological alterations in the reproductive tract of male dogs with Canine Visceral Leishmaniasis

Histopathological alterations in the reproductive tract of male dogs with Canine Visceral Leishmaniasis

Expression of EGF receptors in canine prostate with proliferative inflammatory atrophy and carcinoma

Matrix metalloproteinases 2 and 9 expression in canine normal prostate and with proliferative disorders

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