Effects of meloxicam administered by different routes to control experimental uveitis in dogs

Abstract

II Effects

Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats

“…(GILMOUR & LEHENBAUER, 2009;RIBEIRO et al, 2009;PINARD et al, 2011), and lower than in horses (HILTON et al, 2011). However, cats in the CT group showed significantly higher baseline levels of aqueous PGE 2 than the other groups.…”

“…In dogs, several studies have been conducted in order to evaluate the efficaciousness of systemic administered COX-2 selective NSAIDs for controlling the breakdown of the BAB (GILMOUR & LEHENBAUER, 2009;RIBEIRO et al, 2009;PINARD et al, 2011). However, only one study has described the effects of oral meloxicam in cats with experimentally-induced uveitis (RANKIN et al, 2013).…”

Effects of different mydriatics on intraocular pressure, pupil diameter, and ruminal and intestinal motility in healthy sheep

“…In spite of it, atropine eye drops proved to produce a longer‐lasting effect of 13 h and to promote a more pronounced pupillary dilation (0.9 mm) when compared with the same drug delivered through the subconjunctival route. Studies in dogs demonstrated that subconjunctival route was less efficient in stabilizing blood–aqueous barrier than the topical route after the use of anti‐inflammatory drugs . Considering the average ± SD weight of 35.73 ± 1.23 kg of the individuals used in the study, an injection of 0.4 mL (4 mg/injection) did not exceed the total dose allowed for the species (0.05–0.20 mg/kg) and was chosen based on the veterinary literature and the volume tolerated by this route of administration …”

Effects of morphine on the expression of cytokines and inflammatory mediators in a rabbit model of endotoxin-induced experimental uveitis

“…In corroboration, a recent study reported significantly increased expression of TNF-α at 18 hours after cataract surgery (11) . Prostaglandins (PGs) have also been shown to cotribute to intraocular inflammation (12)(13)(14) . Infectious disease, trauma, ocular surgery, and neoplasia may also cause injury to the aqueous-blood barrier, leading to increased PG synthesis (7) .…”

“…Infectious disease, trauma, ocular surgery, and neoplasia may also cause injury to the aqueous-blood barrier, leading to increased PG synthesis (7) . Ribeiro et al (13) and Gilmour and Payton (14) reported the utility quantifying prostaglandin E2 (PGE2) levels as a measure of intraocular inflammation in dogs.…”