Metastasizing oral melanoma in a cow

Brito, Marilene de Farias; França, Ticiana N.; Jabour, Flávia Figueiraújo; Seixas, Josilene Nascimento; Andrade, Gisele Braziliano de; Oliveira, Laura Iglesias de; Peixoto, Paulo Vargas

doi:10.1590/s0103-84782009005000055

Cited by 13 publications

(16 citation statements)

References 13 publications

(18 reference statements)

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“…A localização do tumor primário coincide com o relato de 7 casos de mela nomas, sete ocorreram na pele, quatro casos em equi nos, dois em caprinos e um bovino [2]. No presente estudo foram ainda identificados focos metastáticos em órgãos como rins, fígado, pulmões, coração, vértebras, costelas e vértebras, fato este também descrito em dois bovinos que apresentavam metástase em linfonodos, pulmão, coração, endocárdio, epicárdio, omento, peritônio, fígado e glândula mamária [1]. Em um caprino foi relatado metástase para linfonodos, fígado e glândulas salivares [7], entretanto, em dois caprinos foi acompanhada a evolução do melanoma e não foi evidenciada metástase em nenhum dos animais dois meses e um ano após o diagnóstico [4].…”

Section: Discussionunclassified

Metastastic Melanoma in a Goat

Melo-Neto

Correia

Mesquita

et al. 2019

Acta Scientiae. Vet.

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Background: Melanoma is one of the 5 neoplasia types of that most frequently affect skin and subcutaneous tissue, especially in Northeastern Brazil, where there is a high incidence of solar rays. It is a tumor that affects melanocytes and is characterized by diverse morphologies ranging from round to polygonal cells, including epithelioid cells, spindle cells, star-shaped or with a mesenchymal appearance, and presenting large amounts of melanin in the cytoplasm. The pigment can be found in the cytoplasm of macrophages, indicating the phagocytic activity at the site. The nucleus is basophilic, and mitotic figures are not numerous. Case: A 12-year-old female goat with a history of nodular lesion in the nasal region with progressive increase and recurrence was submitted to clinical evaluation. The tumor presented suggestive characteristics of melanoma, such as elevated irregular and surface with a central region of black colored skin. After surgical removal of the nodule, recurrence was observed in infra-orbital and parotid regions with infiltration of the mandible. Hence, the malignant behaviour of the tumor indicated euthanasia of the animal. The owner authorized the procedure and the individual was then submitted to necropsy at the Animal Pathology Sector of the Federal Rural University of Pernambuco, Academic Unit of Garanhuns (UAG/UFRPE). At necropsy, findings included a tumor in the parotid region with infiltration to the mandible, multiple tumors of black or grayish-white color in liver, multifocal nodules of grayish color in the right kidney and left kidney also had tumors of the same colorations, in the thoracic cavity, blackened spots were observed in the sternum. The lungs had several black colored nodules distributed throughout the organ. Microscopic examination revealed metastatic cells with intracytoplasmic brown pigments, in addition to granular and pleomorphic aspect. The lymph nodes presented the higher number of metastatic foci. Tumor cells were observed in metastatic nodes surrounded by disorganized tissue in organs, such as liver, right kidney, mandible and lungs. Discussion: The diagnosis was concluded based on the metastatic foci found in the several organs along with macroscopic aspects of the tumors and the histopathological evaluation. In addition, the findings were also confirmed with data found in the scientific literature. The clinical evolution and the appearance of new metastatic foci in only three weeks indicated that it was a tumor with a high degree of invasiveness. The evolution period was shorter than the reports described in the literature. Also in an unusual manner, the numerous metastatic foci in several organs compromised the general status of the animal. The involvement of the liver and lung parenchyma by the tumor, considerably diminishing the functionality of these organs, and the macroscopic characteristics with darkened aspect, microscopically correspond to areas of metastatic foci. The histopathological evaluation of the white or yellow areas revealed necrosis with adjace...

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Section: Discussionunclassified

Metastastic Melanoma in a Goat

Melo-Neto

Correia

Mesquita

et al. 2019

Acta Scientiae. Vet.

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“…No baço não foi observado infiltrado de células do melanoma embora, este órgão estivesse bem reativo, com polpas brancas contendo grandes centros germinativos com linfoblastos. A medula óssea da mandíbula e vertebras, por sua vez, possuem metástases de células melocíticas e amelanocíticas DISCUSSÃO O animal atendido no AGA/UFRPE, era proveniente de uma região com alta incidência de radiação UV e da raça Saanen, caracterizada pela pele com pouca pigmentação [18], esses fatores ambiental e racial tornaram mais propício o desenvolvimento da neoplasia através das mutações secundárias formadoras de lesões melanocíticas [4,9], apesar da mesma ter sido a única acometida dentre um rebanho de cinquenta caprinos mestiços e da raça Saanen.…”

Section: Casounclassified

“…Os sinais clínicos variam devido a evolução do quadro, quantidade e localização da massa tumoral [8,14], principalmente após sua excisão cirúrgica na presença de metástase, como observado no paciente do relato. O quadro de letargia, anorexia, perda de peso progressiva e alterações pulmonares, foi semelhante ao descrito em cabra que apresentou recidiva após 105 dias da excisão do melanoma na base do chifre [15] e em vaca com melanoma oral [4]. A gravidade da condição clínica do animal ficou evidente nas alterações leucocitárias e bioquímicas encontradas.…”

Section: Casounclassified

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Melanoma in a Dairy Goat

Rizzo

Araújo

Silva

et al. 2019

Acta Scientiae. Vet.

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Background: Skin neoplasms in goats, albeit less frequent than in equines and cattle, are no less important, given that the presence of melanoma is worrisome due to its local and metastatic aggressiveness, which leads to death, especially in northeastern Brazil, where ultraviolet (UV) radiation levels are high, being an important factor the development of this neoplasia, especially in light-skinned animals. This report describes the clinical and pathological aspects, beyond the attempted surgical treatment a case of Saanen goat melanoma raised in Feira Nova, Pernambuco, Brazil. Case: A 4-year-old pregnant Saanen goat was treated at the AGA/UFRPE. The animal presented blackened fetid masses located on the lower lip and ventral region of the jaw that had grown for two months. In addition to the tumor, a physical examination revealed altered submandibular and left prescapular lymph nodes. Local anesthesia and sedation were applied and both neoplasms were excised. The goat was then medicated with anti-inflammatory and antibiotic drugs and discharged. However, 45 days later, the goat returned with multiple nodules similar in appearance to the previous one and in a severe clinical condition, characterized by pale mucous membranes, dehydration, enophthalmia, bilateral nasal serous secretion and enlargement of the lymph nodes mandibular, retro pharyngeal and right paratid, as well as slight respiratory snores in the ventral portion of lungs and productive cough. Due to the unfavorable prognosis, the animal was euthanized. Macroscopic findings revealed multiple nodular, infiltrative and blackened lesions on the tongue, lung, kidneys and liver, enlarged and blackened lymph nodes, and sagittal section of the cervical spine identified a dark spot on the seventh thoracic vertebra. In the histological evaluation of necrotic lesions present in the skin, lung, liver and kidneys was observed nodular infiltration of anaplastic cells was noted, with anisocytosis, anisocariosis, multiple nucleoli and intracytoplasmic granulation compatible with melanin and larger amelanotic cells compatible with cells high degree of malignancy. The bone marrow of the mandible and vertebrae, in turn, have melocytic and amelanocytic cell metástases. Discussion: The animal's region of origin is characterized by high incident solar radiation, which, allied to skin depigmentation in this breed, favor the formation of neoplasms. Clinical signs are multifactorial, depending on the lesion, and may be nonspecific, as in this case. Ninety percent of cases occurring in the region of the mouth are malignant. The initial tumoral mass was located in the lower lip, which corresponds to the second region of highest incidence reported in the literature. Despite the aggressive and metastatic characteristics of melanomas, surgical excision and/or cryosurgery are the only forms of treatment, with a poor to reserved prognosis, depending on the occurrence of locoregional lymph node metastasis. Early detection can be achieved by aspiration biopsy cytology, which may sugge...

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“…The incidence is occasional in Duroc and Sinclair miniature swine (SMITH et al, 2002). Melanocytic tumors may also occur in other domestic species, such as cattle, sheep, and goats (BABIC et al, 2009;BRITO et al, 2009;VALA et al, 2012;FAZILI et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Melanoma maligno em búfalos (Bubalus bubalis) albinos

et al. 2015

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<p>Two albino water buffalo affected by multiple melanocytic tumors in Southern Brazil are described. Grossly, there were multiple dark tumors within the skin, skeletal muscle, lungs, and lymph nodes. The tumor was also present in the pericardial sac, renal capsule, mediastinum and pleura. Microscopically, the tumors consisted of polyhedral epithelioid cells arranged in solid nests or interwoven fascicles supported by a thin and sparse collagenous stroma. The cytoplasm was eosinophilic and sometimes contained varying amounts of melanin pigment. The mitotic rates were low. Immunohistochemistry staining with Tyrosinase, Melan-A, Vimentin, S-100 protein, and neurofilament were positive. It is possible that the polymorphisms related to pigmentation in albino buffalo contributed with a high risk of developing melanoma as suggested in humans.</p>

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Metastasizing oral melanoma in a cow

Cited by 13 publications

References 13 publications

Metastastic Melanoma in a Goat

Metastastic Melanoma in a Goat

Melanoma in a Dairy Goat

Melanoma maligno em búfalos (Bubalus bubalis) albinos

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