Pulmonary choristoma associated with calf meningocele

Oliveira, Diego M.; Medeiros, J. M.; Araújo, Ana Lucélia de; Pimentel, Luciano da Anunciação; Pierezan, Felipe; Neto, E. G. Miranda; Dantas, Antônio Flávio Medeiros; Riet-Correa, Franklin

doi:10.1590/s0103-84782009000900045

Cited by 8 publications

(20 citation statements)

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“…Convém citar que avaliações radiográficas em suínos com essas malformações não foram encontradas na literatura consultada. Por outro lado, há dois estudos de casos de meningocele e meningoencefalocele em bovinos nos quais houve uso do exame radiográfico [24,34].…”

Section: Discussionunclassified

Meningocele and Meningoencephalocele in Piglets: Pathologic and Imaging Aspects

Sousa

Oliveira

Muramoto

et al. 2020

Acta Scientiae. Vet.

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Background: Meningocele and meningoencephalocele are rare congenital deformities characterized by herniation of the meninges and of the meninges and brain tissue through a bone defect in the skull (cranioschisis), respectively. Descriptions of these malformations in pigs are scarce in the international literature and non-existent in Brazil, with only one case of cranioschisis with brain exposure (without protrusion of the meninges and covered by skin) reported to date. Here, we report a case of meningocele and another of meningoencephalocele in piglets in the state of Bahia and describe the main related anatomopathological and imaging characteristics (radiographic and ultrasonographic).Case: The congenital malformations occurred in newborn piglets from a farm located in the city of Catu, Bahia, Brazil, which presented with an evident large saccular area positioned dorsally to the head. The animals died 48 h after birth and were referred to the Laboratory of Animal Pathology of the Federal University of Bahia, for the studies and diagnostic conclusion. Postmortem ultrasound examinations showed that the region was filled with fluid and associated with a small brain protrusion in case 1 and a defect in the skull bone, which had its orifice dimensions estimated. Despite the superimposition of structures, the skull malformation was identified on radiographic examination (case 1) and measured on ultrasonographic examination (cases 1 and 2). During necropsy, the piglets presented with a marked marked bulge of saccular appearance under the skin in the frontal region. The saccular formation was floating, internally covered by dura mater and filled with reddish serous liquid (liquor).Discussion: The diagnoses of meningoencephalocele and meningocele in newborn piglets were established based on morphological changes identified on ultrasound and necropsy. Although the ultrasound diagnosis of meningocele and meningoencephalocele are routinely made in human medicine, they are still limited in veterinary medicine in cases of malformations in production animals, with no case report in pigs. A Brazilian textbook on pig diseases cites these diseases among the main malformations that affect this species, although data on epidemiology and anatomopathological and imaging findings are not described, which highlights the importance of this study. As for the etiology of these malformations, the occurrence of two cases in piglets from the same farm in the present report may suggest the presence of genetic factors. The confirmation that inbreeding is common at farms where the cases occurred, and absence of herd renewal since 2014 (continuous use of the same breeders), reinforced this hypothesis, since inbreeding results in serious reproductive and productive disorders due to increased homozygosis and, consequently, due to the frequency of genotypes with recessive genes that cause various malformations in animals. This fact reinforces the need to make producers aware of the importance of avoiding inbreeding and the use of breeders that have generated malformed piglets to reduce the frequency of malformations. Additional studies on congenital malformations in pigs in Brazil are necessary because of the scarcity of existing data, particularly regarding the etiology and anatomopathological and imaging characteristics of these diseases.

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Section: Discussionunclassified

Meningocele and Meningoencephalocele in Piglets: Pathologic and Imaging Aspects

Sousa

Oliveira

Muramoto

et al. 2020

Acta Scientiae. Vet.

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“…A retrospective study using 28 bovine cases with PCs confirmed the subcutaneous involvements of these lesions in approximately 32% of animals, compared with approximately 68% of animals with intra-abdominal and intra-thoracic lesions ( 21 ). The other previous bovine report described the prevalence of these disease’s thoracic, abdominal and subcutaneous involvements as approximately 10, 50 and 40%, respectively ( 16 ). Additionally, the anatomical positions where the subcutaneous lesions have been affected are the head, neck, shoulder, chest, back, and anus ( 4 , 9 , 16 , 19 , 22 , 23 ).…”

Section: Introductionmentioning

confidence: 92%

“…Extralobar pulmonary sequestration accounts for 14%–26% of human cases of pulmonary sequestration ( 10 , 14 ). In the veterinary literature, the congenital anomalies derived from lung tissues have been referred to by other names, including pulmonary sequestration ( 15 , 16 ), an ectopic or accessory lung ( 17 , 18 ), bronchopulmonary foregut malformation ( 19 ) and PC ( 3 , 4 , 9 , 20 ). A retrospective study using 28 bovine cases with PCs confirmed the subcutaneous involvements of these lesions in approximately 32% of animals, compared with approximately 68% of animals with intra-abdominal and intra-thoracic lesions ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: Diagnosis and treatment of pulmonary choristoma in a newborn calf

Usaki,

Tsuka,

Hatanaka

et al. 2024

Front. Vet. Sci.

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A 4-day-old female Holstein calf presented with a large-sized, protruding mass in its back, at birth. Radiography identified the deformed spinous process in the second and third lumbar vertebras, suggesting spina bifida. Ultrasonography of the back mass revealed anechoic bronchi-like structures and large vessels with rich blood flow running parallel within the homogenous echogenic mass’s parenchyma. Doppler ultrasonography also revealed pulsatile vessels entering into the deeper side of the transverse process of the lumbar vertebras at the right-sided base of the protruding mass. These imaging results were helpful for surgical planning, in which a large arterial vessel was sutured at the right-sided mass’s base, followed by resection of the mass itself. The mass’s resection could be carried out according to the planned surgical procedure, though its invasion was too deep to be resected completely. Histopathology for the resected specimens revealed that the mass mainly had lung-tissue-like structures comprised of bronchi-, bronchiole- and alveoli-like structures, and large vessels, allowing the diagnosis of pulmonary choristoma. Doppler ultrasonography could contribute to the differentiation between the bronchi-like tubular structure and the large arterial vessels on the same images, aiding diagnosis of this disease.

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“…The ocular region is another described location for choristomas, frequently termed ocular dermoid, that usually present as a unilateral lesion (BRUDENALL et al, 2008), with a similar low prevalence in all breeds, other than the Hereford (BARKYOUMB; LEIPOLD, 1984). Oliveira et al (2009) described a pulmonary choristoma associated with a meningocele in a bovine; however, the animal did not present any neurological signs and the mass was located at the subcutaneous tissue of the frontal region of the skull, preventing cranial symphysis closure. Prevalence studies providing evidence of which age range is the most frequently affected were not found; however, according to Bassi et al (2010), Brudenall et al (2008) and Oliveira et al (2009), choristomas have a higher occurrence in young cattle.…”

Section: Introductionmentioning

confidence: 95%

“…Case descriptions of choristoma in domestic animals are uncommon to rare (WHITTEN et al, 2006), with reports in cattle (BASSI et al, 2010;BINANTI et al, 2012;BRUDENALL et al, 2008;OLIVEIRA et al, 2009), canines (BENTLEY et al, 2006WHITTEN et al, 2006) and felines (FRANÇA et al, 2010). In cattle, there are descriptions of different tissues proliferating within the thoracic cavity, diaphragm, retroperitoneal region, adrenal gland region, and subcutaneous tissue (BASSI et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Collagenous choristoma at the cerebellar peduncle of a Nelore bull

et al. 2015

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Choristomas are mature normal tissues in abnormal anatomical positions. Reports in domestic animals are uncommon to rare, usually restricted to cattle, with the proliferation of different tissues in various locations, such as subcutaneous tissue, thoracic cavity, retroperitoneal and ocular regions. No age range is predominantly affected, but there are more reports in young cattle. The Laboratory of Veterinary Pathology at the Universidade Federal do Rio Grande do Sul received a brainstem sample of a bull, Nelore breed, 5 years old, from the project of Supplementary Diagnostic Methods of Transmissible Spongiform Encephalopathies (TSEs). The animal presented recumbency at the time of slaughter; was alert, with a complete fracture to the right femur and without neurological signs. On gross examination, there was a white oval firm mass, located caudally to the left caudal colliculus, on the left cerebellar peduncle. In the microscopic examination, there was a well-demarcated area, unencapsulated and composed predominantly of connective tissue fibers (collagen). Immunohistochemical examination for glial fibrillary acidic protein was negative. Due to the gross and microscopic characteristics, a diagnosis of collagenous choristoma at the cerebellar peduncle was established, since the presence of collagen within the brain tissue itself is abnormal. Key words: Brain, ruminant, tumor-like lesions ResumoCoristomas são tecidos normais maduros em posições anatômicas anormais. Relatos em animais domésticos são incomuns a raros, restringindo-se geralmente à espécie bovina, com proliferação de diferentes tecidos em várias localizações, como tecido subcutâneo, cavidade torácica, região retroperitoneal e ocular. Não há uma faixa etária predominantemente afetada, porém há mais relatos em bovinos jovens. O Laboratório de Patologia Veterinária da Universidade Federal do Rio Grande do Sul recebeu uma amostra de tronco encefálico de um bovino Nelore, macho, cinco anos de idade, vinculado ao projeto de Complementação de Métodos Diagnósticos de Encefalopatias Espongiformes Transmissíveis (EETs). O animal apresentava-se no momento do abate em decúbito; estava alerta, com uma fratura completa no fêmur direito e sem sinais neurológicos. No exame macroscópico, observou-se uma massa branca oval, firme, localizada caudalmente ao colículo caudal esquerdo, sobre o pedúnculo cerebelar esquerdo. No exame microscópico, observou-se uma área bem delimitada, não encapsulada, composta predominantemente por fibras de tecido conjuntivo fibroso (colágeno). O exame imuno-histoquímico para proteína ácida fibrilar glial foi negativo. Devido às características macroscópicas e microscópicas, o diagnóstico de coristoma colagenoso foi estabelecido, visto que a presença de colágeno no encéfalo é anormal.

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Pulmonary choristoma associated with calf meningocele

Abstract: Pulmonary choristoma is a rare malformation reported in different animal

Cited by 8 publications

References 1 publication

Meningocele and Meningoencephalocele in Piglets: Pathologic and Imaging Aspects

Meningocele and Meningoencephalocele in Piglets: Pathologic and Imaging Aspects

Case report: Diagnosis and treatment of pulmonary choristoma in a newborn calf

Collagenous choristoma at the cerebellar peduncle of a Nelore bull

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