Edema maligno em suíno

Pinto, Flávia Ferreira; Assis, Ronnie Antunes de; Lobato, Francisco Carlos Faria; Vargas, Agueda Castagna de; Barros, Ricardo Rocha de; Gonçalves, Luciana Aramuni

doi:10.1590/s0103-84782005000100038

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…3), 20,53,65,70 it has also been described in other domestic mammals, including goats, 27,30 pigs (Fig. 4), 54 dogs, and cats. 53,56,62 Individual cases of gas gangrene have also been described in several wild animal species including an Indian elephant (Elephas maximus), 59 a guanaco (Lama pacos), 78 a lynx (Lynx canadensis), 33 and a brown bear (Ursus arctos).…”

Section: Introductionmentioning

confidence: 85%

Gas gangrene in mammals: a review

et al. 2020

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Gas gangrene is a necrotizing infection of subcutaneous tissue and muscle that affects mainly ruminants and horses, but also other domestic and wild mammals. Clostridium chauvoei, C. septicum, C. novyi type A, C. perfringens type A, and C. sordellii are the etiologic agents of this disease, acting singly or in combination. Although a presumptive diagnosis of gas gangrene can be established based on clinical history, clinical signs, and gross and microscopic changes, identification of the clostridia involved is required for confirmatory diagnosis. Gross and microscopic lesions are, however, highly suggestive of the disease. Although the disease has a worldwide distribution and can cause significant economic losses, the literature is limited mostly to case reports. Thus, we have reviewed the current knowledge of gas gangrene in mammals.

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Section: Introductionmentioning

confidence: 85%

Gas gangrene in mammals: a review

et al. 2020

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“…5 Clostridium perfringens has been reported more commonly in human than in animal cases of gas gangrene (previously referred as malignant edema). 8,10 In animals, gas gangrene has a higher incidence in ruminants 13 and horses, 1,16 with scattered reports in other species, including pigs, 17 cats, 22 and dogs. 20,23 Despite the numerous cases of gas gangrene reported in other mammals, there are no reports of generalized fatal gas gangrene in dogs, to our knowledge.…”

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confidence: 99%

Fatal non-traumatic gas gangrene caused by Clostridium perfringens type A in a Siberian Husky dog

et al. 2022

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An 8-y-old, castrated male Siberian Husky dog was admitted to an emergency clinic with acute collapse and severe swelling of both forelimbs, ventral thorax, and axillary region. The clinical assessment, with laboratory tests and radiologic investigation, confirmed severe subcutaneous emphysema and multi-organ failure. The animal died while receiving emergency treatment. On postmortem examination, Clostridium perfringens was isolated from the subcutaneous fluid and the effusion from the thoracic and abdominal cavities. Relevant histopathology findings included subcutaneous emphysema and multi-organ perivascular and intravascular, intralesional myriad 0.5–3-µm gram-positive rod bacteria, with no associated inflammation. Whole-genome sequencing and phylogenetic analysis identified C. perfringens type A. Virulence genes detected included cpa (alpha toxin), cadA (v-toxin), colA (collagenase A), nagH (hyaluronidase), nanH, nanI, nanJ (sialidases), and pfoa (perfringolysin). These virulence genes have previously been reported to act synergistically with alpha toxin in C. perfringens–mediated gas gangrene.

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