Nematódeos resistentes a anti-helmíntico em rebanhos de ovinos e caprinos do estado do Ceará, Brasil

Melo, Ana Carolina Fonseca Lindoso; Reis, Iarle Feitosa; Beviláqua, Cláudia Maria Leal; Vieira, L. da S.; Echevarria, F. A. M.; Melo, Luciana Magalhães

doi:10.1590/s0103-84782003000200024

Cited by 63 publications

(44 citation statements)

References 18 publications

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“…Dados similares ao de Gatongi et al (2003) na África com 59,7% na redução de ovos em caprinos. No Brasil, Mattos et al (2004) e Melo et al (1998Melo et al ( , 2003 verificaram a eficácia da ivermectina 42,10 % aos 14 dias pós-tratamento em Porto Alegre e 69% aos 10 dias no Ceará. Dados que discordam com o de Mattos et al (2003) que observaram eficácia de 93,24%.…”

Section: Resul Resul Resul Resul Results T T T Tados E Discus Ados E Dunclassified

Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do Sertão Paraibano

Rodrigues

Athayde²,

Rodrigues³

et al. 2007

Pesq. Vet. Bras.

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Evalu-Evalu-EvaluEvalu-Evaluation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats raised in the state of P raised in the state of P raised in the state of P raised in the state of P raised in the state of Paraíba araíba araíba araíba araíba.] Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do sertão paraibano. Pesquisa Veterinária Brasileira 27 (4) The objective was to evaluate conventional and alternative anthelminthic action on the sensibility of gastrointestinal nematodes in goats. Hundred and twenty goats of both sexes were distributed into 10 groups of 24 animals each (12 males and 12 females) and submitted to treatments of specific anthelminthic composition. The commercial drugs used were moxidectin 0.2%, albendazole, levamisol chlorhydrate, ivermectin and an aqueous extract of the purgative potato (Operculina hamiltonii). The reduction test was applied through egg counts per gram of feces and larval culture to evaluate resistance. The fecal samples were collected in the day when medication was accomplished (day base), at 7, 14 and 21 days after treatment. The following results for the reduction of Trichostrongyloidea eggs were obtained: Treatment of the females with Moxidectina reduced the egg counts to 92.8, 88.7 and 89.8%, of the males to 92.6, 96.2 and 98.1%; with Levamisol of the females to 96, 97.1 and 91%, of the males to 85.7, 94,2 and 100%; with Albendazol of the females 65, 60.3 and 75.4%, of the males 88.8, 88.8 and 55.5%; with Ivermectin of the females to 92.2, 68.6 and 70.6%, of the males to 41.7, 73.6 and 59.7%; and with the purgative potato of the females to 31.8, 34.1 and 49.4%, of the males to 61.5, 80.7 and 50%. In larval culture Haemonchus, followed by Bunostomum, Trichostrongylus, and Oesophagostomum, were identified even after treatments.

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Section: Resul Resul Resul Resul Results T T T Tados E Discus Ados E Dunclassified

Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do Sertão Paraibano

Rodrigues

Athayde²,

Rodrigues³

et al. 2007

Pesq. Vet. Bras.

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“…A contagem média de 1.731 OPG, relatada nesse trabalho; com amplitude das médias, nos rebanhos, variando de 201 a 5.893 OPG (Quadro 1), é superior aos resultados descritos por Melo et al (2003), em estudo realizado no estado do Ceará e por Köse et al (2007), na Turquia, que descreveram médias de 469 e de 868 OPG, respectivamente; e inferior aos resultados de Mwamachi et al (1995), no Kênia e Soccol et al (1996), no estado do Paraná, Brasil, com médias de 3.197 e 2.237, respectivamente. No rebanho identificado como Porto Murtinho (Faz.2), o teste de redução não foi realizado, em virtude da baixa contagem de OPG; esta situação foi atribuída ao tipo de manejo empregado, que consistia no pastejo consorciado com bovinos.…”

Section: Discussionunclassified

“…Com relação à molécula Ivermectina, não diferem do descrito por Soccol et al (1996), Molento (2004) e Rosalinski-Moraes et al (2007). Outros estudos revelam índices de resistência mais baixos (Melo et al 2003, Álvarez-Sánchez et al 2006, Traversa et al 2007, Köse et al 2007); mas considerando a situação desse fenômeno no mundo, é possível dizer que existe tendên-cia de aumento nos níveis de resistência pela persistên-cia do uso desta base, em virtude da cultura dos criadores em atribuir a ela alta eficiência facilitada pela redução do preço dessa formulação. A formulação contendo Closantel apresentou alto ín-dice de resistência anti-helmíntica nos rebanhos testados, semelhante ao descrito por Soccol et al (1996) e Chandrawathani et al (1999).…”

Section: Discussionunclassified

“…A formulação contendo Levamisole foi eficiente na redução do OPG em dois rebanhos, indicando a presença de isolados de helmintos resistentes em 86,7% das propriedades testadas (Quadro 2), semelhante ao descrito por Echevarria et al (1996); mas superiores aos encontrados por Melo et al (2003), Rosalinski-Moraes et al (2007) e Soccol et al (1996, onde 41,2%; 44,4% e 33,3% das propriedades estudadas apresentaram isolados de helmintos resistentes, respectivamente. E inferiores aos relatados por Gill (1996), Farias et al (1997) e Traversa et al (2007, onde a resistência foi relatada, respectivamente, em 100%; 95,7% e 100% dos rebanhos.…”

Section: Quadro 4 Percentuais Da Condição De Resistência (R) Baixa unclassified

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Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul

Sczesny-Moraes

Bianchin²,

Silva³

et al. 2010

Pesq. Vet. Bras.

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ABSTRACT.-Sczesny-Moraes E.A., Bianchin I., Silva K.F., Catto J. Among the methods of control of gastrointestinal worms in sheep, the use of chemicals is the most common. However, the continued, and indiscriminate, use of these products has selected populations of resistant helminths to anthelmintics, a phenomenon reported in the whole world. This study aimed to identify the species of gastrointestinal parasites and diagnose the status of anthelmintic resistance in sheep in the State of Mato Grosso do Sul Brazil. Feacal egg count reduction tests (FECRT) were performed in flocks of sixteen farms, and the seven formulations used contained the following pharmacological bases: Albendazole, Ivermectin, Levamizol, Trichlorfon, Moxidectin, Closantel and one containing the first three in association. The species identified at necropsy, in adult sheep, were: Haemonchus contortus, Trichostrongylus colubriformis, Cooperia curticei, C. punctata, C. pectinata and Oesophagostomum columbianum, in order of prevalence. The formulations containing Albendazole and Ivermectin did not show efficacy in reducing the EPG in the flocks tested, with average reductions of 0.7 and -19.6%, respectively. Closantel presented an average efficacy of 6.7%; Levamisolee, Moxidectin and Trichlorfon, 28.7, 26.8 and 65% respectively, the combination of three bases (Albendazole, Ivermectin and Levamizol), an average efficacy of 55.8 %. The average percentages of infective larvae recovered in the faecal cultures, pre and post treatment were similar, indicating that resistance to the bases tested is present in all species cited, to a greater or lesser degree. The two genera predominantly resistant are Haemonchus sp., with 86.9%, followed by Trichostrongylus sp., with an average of 47.5%, Strongyloides sp. 33.6%, Oesophagostomum sp.

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“…Furthermore, there is rapid development of anthelmintic resistance (Melo et al, 2003). According to Alawa et al (2003), declining funding and rising costs of veterinary services cause difficulties in access to these services by resource-poor communities.…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic and cytotoxic activities of extracts of Markhamia obtusifolia Sprague (Bignoniaceae)

Nchu¹,

Githiori²,

McGaw³

et al. 2011

Veterinary Parasitology

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The anthelmintic activity of Markhamia obtusifolia Sprague (Bignoniaceae) leaf extracts was evaluated against the ruminant gastrointestinal nematode parasite Trichostrongylus colubriformis (Nematoda: Strongylida) using the in vitro egg hatch test. Also, the cytotoxic activity of aqueous extracts of M. obtusifolia was evaluated in cell line cytotoxicity assays. The results indicated that the effective concentration (EC 50 ) for the water extract of M. obtusifolia leaves (0.46 mg/mL; Confidence Interval[CI] 0.3-0.5 mg/mL) was significantly lower than the EC 50 for the acetone extract of M. obtusifolia (0.8 mg/mL; CI 0.7-1 mg/mL). Aqueous extracts were twice as potent as the acetone extracts. The ED 90 (0.2 mg/mL; CI 0.1-0.02) for thiabendazole (positive control) was significantly lower than the EC 90 for the water extract of M. obtusifolia 2 (10.7 mg/mL; CI 8.3-13.7 mg/mL). In the cytotoxicity bioassay, the lethal concentration (LC 50 ) for the aqueous extract of M. obtusifolia was 0.476 mg/mL, which was relatively high (low toxicity) in comparison to the highly toxic berberine (LC 50 = 9.80 µg/mL). The current study showed that M. obtusifolia plant extracts possess anthelmintic activity and are relatively non-cytotoxic, thus providing support for their use in traditional veterinary practices.

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Nematódeos resistentes a anti-helmíntico em rebanhos de ovinos e caprinos do estado do Ceará, Brasil

Cited by 63 publications

References 18 publications

Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do Sertão Paraibano

Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do Sertão Paraibano

Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul

Anthelmintic and cytotoxic activities of extracts of Markhamia obtusifolia Sprague (Bignoniaceae)

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