Emprego da associação flunitrazepam/droperidol na tranqüilização de suínos

Abstract

Na presente pesquisa avaliou-se a associação flunitrazepam/droperidol na tranqüilização/sedação de 12 suínos da raça Landrace. Os animais foram divididos em dois grupos (GI e GII). Nos grupos I e II foram anotadas as frequências cardíaca, respiratória e temperatura retal antes e após a administração do flunitrazepam (0,03 mg/kg IM) associado ao droperidol (0,4mg/kg IM). No grupo II realizaram-se também análises hemogasimétricas. As anotações paramétricas e hemogasimetria arterial foram repetidas durante uma hora após a administração das drogas, com intervalos de 10 minutos. Concomitantemente efetuaram-se observações a respeito da eficácia da tranqüilização. Não ocorreram alterações significativas nos dados paramétricos e equilíbrio ácido-básico. O tempo médio de ação das drogas foi de 60 minutos, com período de latência de 5 minutos. Durante a tranqüilização houve relaxamento muscular, indiferença a estímulos ambientais, perda dos reflexos posturais e manutenção dos reflexos protetores. A análise dos resultados permite indicar a associação flunitrazepam/droperidol na tranqüilização de suínos.

Blood gas analysis in pigs submitted to different concentrations of nitrous oxide or oxygen, under different ventilatory modalities

“…It is important to highlight that both pH and bicarbonate are appreciably higher in pigs than in humans (Hannon, et al, 1990). In their study on pigs under the effect of flunitrazepam and droperidol, Marques et al (1995) showed means between 7.43 and 7.44 for pH. Later, while standardizing physiological parameters of awake pigs, Gianotti (2010) verified means between 7.45 and 7.54.…”

“…Regarding bicarbonate (HCO 3 -) (Table 1), Gianotti (2010) reported mean values between 27.8 and 36.6mEq/L in awake pigs, while Marques et al (1995) verified values between 20 and 23mEq/L when administering a combination of flunitrazepam and droperidol to pigs. The data obtained herein are in agreement with those reported by Gianotti (2010).…”

“…Regarding oxygen saturation (SaO 2 ) in anesthetized patients administered oxygen, this should be maintained between 96 and 100% to ensure adequate tissue oxygenation (McDonell and Kerr, 2007). No statistically significant variations occurred under spontaneous ventilation, and as soon as positive pressure MV was introduced, the values remained above the expected physiological range for the proposed anesthetic conditions at the same time points, indicating adequate tissue oxygenation.…”

“…While analyzing arterial blood samples of awake pigs, Gianotti (2010) observed a mean of 7.57±2.86mEq/L for this parameter. In comparison, Marques et al (1995) analyzed the BD of pigs administered a combination of flunitrazepam and droperidol, recording a mean of -1.01±8.13mEq/L. It is evident that in relation to pigs, there is no consensus regarding a standardized BD, particularly pigs administered anesthesia with propofol, submitted to different FiO 2 levels in association with compressed air or nitrous oxide.…”

“…Several factors can influence the acid-base balance, leading to acidemia. According to Marques et al (1995), researchers must take into account numerous characteristics that can directly influence blood gas parameters, including sex, age, climatic conditions, time of day, breed and stress. Among these factors, stress evidently influenced pH, since even the use of preanesthetic medication was insufficient to induce decubitus in the pigs and handling them for venoclysis.…”