Double-blind, crossover, placebo-controlled clinical trial with clobetasol propionate in desquamative gingivitis

Abstract

The aim of this study was to evaluate the efficacy of a 0.05% clobetasol propionate ointment administered in trays to 22 patients with desquamative gingivitis in a double-blind, crossover, placebo-controlled trial. Patients received container number 1 and were instructed to apply the ointment 3 times a day for 2 weeks, and to reduce the application to once a day in the third week. Next, the patients were then instructed to discontinue the treatment for 2 weeks, and were then given container 2, used in the same way and for the same length of time as container 1. Regarding signs, 17 patients presented some improvement, while 5 experienced worsening with clobetasol propionate. With the placebo, 14 patients presented some improvement, and 8 patients presented worsening. For symptoms, there was complete improvement in 2 patients, partial improvement in 12, no response in 7, and worsening in 1 with clobetasol propionate. With the placebo, there was partial improvement in 8 patients, no response in 12 and worsening in 2. No statistically significant difference was found between clobetasol and placebo (p>0.05). Within the period designed to treat the gingival lesions of the patients, clobetasol propionate did not significantly outperform the placebo.

Interventions for the management of oral lichen planus: a review of the conventional and novel therapies

“…So, it may be used as a monotherapy or as alternative in periods of acute exacerbation. Clobetasol in 0.025% and 0.05% was found to be equally efficacious with no additional benefit achieved with higher dose (Motta et al , ). Steroid in form of mouthwash was found to produce similar results as gel or paste form, but the severity and incidence of adverse effects were more (Ungphaiboon et al , ).…”

Application of a Motivation–Behavioral Skills Protocol in Gingival Lichen Planus: A Short‐Term Study

“…Some of the main problems in the management of gingival lichen planus are attributable to the chronic nature of this disease, with the need for long‐term therapy, and to factors pertaining to patient medical history (liver disease, diabetes, hypertension, and psychologic state). DG is a common gingival manifestation of non‐plaque‐related diseases, but it may also turn into a periodontal plaque‐related issue 24,25 …”

Diagnosis and Management of Desquamative Gingivitis

“…Several treatment methods have been reported (Carrozzo & Gandolfo, 1999;Chan et al, 2002;Endo et al, 2008b;Fatahzadeh et al, 2006;Kirtschig et al, 2003;Lamey et al, 1992;Motta et al, 2009;Nisengard, 1996;Nisengard & Levine, 1995). However, treatment may achieve only a temporary effect if idiopathic or autoimmune diseases are causing the DG.…”