Influence of local tetracycline on the microbiota of alveolar osteitis in rats

Bosco, Joseane Maria Dias; Oliveira, Sérgio Ricardode de; Bosco, Álvaro Francisco; Schweitzer, Christiane Marie; Júnior, Élerson Gaetti Jardim

doi:10.1590/s0103-64402008000200006

Cited by 10 publications

(9 citation statements)

References 19 publications

(23 reference statements)

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“…Although compliance to post-extraction regimen using mouth rinses and prophylactic antibiotics are reported to significantly reduce the incidence of localised alveolar osteitis,1678910 dental surgeons often administered post-extraction regimen without considering patients’ preference for any combination of the regimen based on predictable outcome of the regimen.…”

Section: Discussionmentioning

confidence: 99%

“…However, the use of verbal and written post-surgical instruction was reported to enhance compliance 6. Some studies on the use of post-extraction mouthwash (warm saline, hydrogen peroxide, chlorhexidine) and antibiotics (tetracycline, amoxicillin/clavulanic acid, clindamycin, metronidazole) have reported reduction in the incidence of post-extraction alveolar osteitis 1678910…”

Section: Introductionmentioning

confidence: 99%

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Alveolar Osteitis: Patients′ compliance to post-extraction instructions following extraction of molar teeth

2013

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Background:To evaluate the effect of various combination of post-extraction regimen administered to patients who had intra-alveolar molar tooth extraction.Patients and Methods:One year prospective study involving 76 consenting patients who came for 1-week post-extraction review. The patients were placed on warm saline mouth rinse with (verbal instruction) or without antibiotic and or analgesic therapy (written prescription), after intra-alveolar molar tooth extraction. Information was obtained from the patients through questionnaire and clinical examination.Results:The patients were placed on warm saline mouth rinse (n = 29, 38.2%) only, warm saline rinse, antibiotics (Amoxicillin and metronidazole) and Paracetamol (n = 31, 40.8%), Paracetamol and warm saline rinse (n = 12, 15.8%) and antibiotics (Amoxicillin and metronidazole) and Paracetamol (n = 4, 5.3%). A total of 63 (82.9%) patients complied with the post-extraction regimen, giving a significant high compliance to the post-extraction instructions (P = 0.001). There were 10 (13.2%) cases of post-extraction localised alveolar osteitis, with predilection for the lower molar teeth (n = 6, 7.9%) and a significant predilection for females (n = 8, 10.5%) [P = 0.005]. Overall, there were five (6.6%) cases each of localised alveolar osteitis in the compliant patients (n = 63, 82.9%) and non-compliant patients (n = 13, 17.1%), giving a ratio of 1:13 and 1:3, respectively. There was significant association of compliance with post-extraction instruction and the reduced incidence of localized alveolar osteitis (P = 0.015).Conclusion:This study showed a significant patients’ compliance with post-extraction warm saline rinse, prophylactic antibiotics and analgesic and a corresponding significant reduction in the incidence of localised alveolar osteitis following intra-alveolar molar tooth extraction. This study emphasises the need to properly educate patients on the effect of compliance to various combination of post-extraction regimen.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alveolar Osteitis: Patients′ compliance to post-extraction instructions following extraction of molar teeth

2013

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“…DOX, as other chemically modified tetracyclines (CMT), also possesses other pharmacologic properties that may positively contribute for periodontal healing process 3,18,19 . Previous in vitro studies have demonstrated that DOX inhibits proteases by blocking the conversion of latent proteases into active mature forms and the activation of MMP’s by chelating metal ions 23,24 .…”

Section: Discussionmentioning

confidence: 99%

Nanotechnology in ligature-induced periodontitis: protective effect of a doxycycline gel with nanoparticules

et al. 2010

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ObjectivesThe aim of this study was to test the efficacy of a locally applied 8.5% nanostructured doxycycline (DOX) gel in preventing alveolar bone loss in experimental periodontal disease (ePD) in rats by using the tapping mode atomic force microscopy (AFM).Material and MethodsePD was induced in 24 Wistar rats. Animals were treated with the doxycycline gel topically, immediately after ePD induction, and 3 times a day during 11 days. Four groups (n=6) were formed as follows: Naïve group (animals not subjected to ePD nor treated); non-treated (NT) group (animals subjected to ePD, but not treated); vehicle gel (VG) group (animals subjected to ePD and treated with topical gel vehicle); and DOX group (test group): animals subjected to ePD and treated with the 8.5% DOX gel. In order to investigate topographical changes in histological sections, a novel simple method was used for sample preparation, by etching sections from paraffin-embedded specimens with xylol.ResultsComparing the AFM images, several grooves were observed on the surface of the alveolar bone and other periodontal structures in the NT and VG groups, with significantly greater depths when compared to the DOX group (p<0.05).ConclusionsPeriodontal structures were brought into high relief confirming to be a simple and costeffective method for AFM imaging with ultrastructural resolution. The doxycycline gel was able to afford periodontal surface preservation, with flatter grooves.

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“…Vários estudos têm sido realizados para verificar a efetividade dos medicamentos tópicos na prevenção da alveolite, seja o antibiótico isoladamente ou combinado a outras substâncias ou fármacos (Blum, 2002;Kolokythas et al, 2010;Bosco et al,2008). Os métodos de aplicação são variados, desde a utilização de medicamentos na forma em pó como em suspensão aquosa, ou esponjas de fibrina impregnadas com tetraciclina, clindamicina, ou ainda a lincomicina, apresentando bons resultados (Noroozi;Philbert, 2009).…”

Section: Medidas De Prevenção Do Quadro De Alveoliteunclassified

Estudo histomorfológico e histomorfométrico da reparação tecidual na alveolite provocada em ratos tratada por óleo ozonizado

Sánchez¹,

Pilar²

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A minha Orientadora Maria Cristina Zindel Deboni, a quem eu admiro muito, agradeço pela paciência e dedicação na orientação deste trabalho, obrigada por acreditar em mim. Sua orientação cientifica me proporcionaram um grande enriquecimento profissional e pessoal. Obrigada pelo apoio oportuno.A meus pais Elba e Antonio, exemplo de luta, disciplina, igualmente meus irmãos Beatriz, Elba e Paul, pela força e apoio que me oferecem cada dia para alcançar meus sonhos. Agradeço a Deus por ser abençoada com uma família maravilhosa.Agradeço aos professores, da Disciplina de Cirurgia da FOUSP, em especial a Profa. Dra. Maria da Graça Naclério Homem, pela oportunidade de realizar o curso de Pós-Graduação. Seu compromisso com a ciência eu levarei como lição.Às professoras: Dra. Luciana Corrêa, sempre atenciosa e disposta. Obrigada pelos ensinamentos e apoio quando solicitado. À Dra. Andrea Traina, pelas valiosa colaboração neste trabalho. Ao prof. Dr. Décio dos Santos Pinto Junior, por ter dedicado parte do seu tempo para realização das fotos.Às técnicas de laboratório e clínica: Cida e Natália, e aos secretários Rose, Ângela, Belira e Edson; por facilitar o desenvolvimento desta pesquisa.Aos técnicos do laboratório de patologia bucal Adriana, Elisa, Giovanni, Bia pela orientação na realização da parte laboratorial deste trabalho.As minhas novas amigas: Ana, Heliana, Jenny, Liz, Mario, Roberto e Sonia pela ajuda incondicional quando a seqüência de dificuldades na execução deste trabalho apareceu. Obrigada pela amizade.Aos meus colegas de turma: Alexandre, Gabriel, Leandro, Mariana, Ophir, Rodrigo e Samantha pelo coleguismo.

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Influence of local tetracycline on the microbiota of alveolar osteitis in rats

Cited by 10 publications

References 19 publications

Alveolar Osteitis: Patients′ compliance to post-extraction instructions following extraction of molar teeth

Alveolar Osteitis: Patients′ compliance to post-extraction instructions following extraction of molar teeth

Nanotechnology in ligature-induced periodontitis: protective effect of a doxycycline gel with nanoparticules

Estudo histomorfológico e histomorfométrico da reparação tecidual na alveolite provocada em ratos tratada por óleo ozonizado

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