Efficacy of Carisolv™ as an adjunctive therapy to scaling and root planing on subgingival calculus removal

Grisi, Daniela Corrêa; Salvador, Sérgio Luiz de Souza; Marcantonio, Rosemary Adriana Chiérici

doi:10.1590/s0103-64402006000300007

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…Correlation between plaque formation and periodontal disease etiology was established with the understanding that plaque maturation is the trigger for the start of inflammatory processes (2), which leads to the destruction of periodontal tissues (9). Traditional scaling and root planning are essential procedures in periodontal therapy (10) and rely on mechanical removal of plaque, calculus, root-bound toxins and contaminated cementum (11). A viable dental plaque covers calculus deposits, which contributes substantially to the pathogenesis of bacteria-induced periodontal disease (12).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans and Streptococcus sanguinis

et al. 2011

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New periodontal disease treatments are needed to prevent infection progression. Photodynamic therapy (PDT) is one of the greatest pledges for this purpose. It involves the use of light of specific wavelength to activate a nontoxic photosensitizing agent in the presence of oxygen for eradication of target cells, and can be used for photokilling of microorganisms. This study evaluated in vitro the photodynamic effect of 0.01% toluidine blue-O (TBO) in combination with an AlGaInP diode laser light source on Aggregatibacter actinomycetemcomitans (A.a.) and Streptococcus sanguinis (S.s.). Suspensions (2 mL) containing A.a. and S.s. at 1.5 x 108 CFU/mL concentration were prepared and divided into 3 groups: Control group (no treatment), Dye group (inoculum and TBO for 5 min) and Dye/Laser group (inoculum, TBO for 5 min and laser for 3 min). Next, a dilution for subsequent subculture in 20 mL of Trypic Soy Agar (A.a) and Brucella Agar (S.s.) in Petri dishes (Pourplate Method) was done. Incubation of A.a. in microaerophilia and S.s. in aerobiosis at 35oC for 48 h was performed for subsequent visual counting of CFU/mL. Data were analyzed by one-way ANOVA and Tukey's HSD test at 5% significance level. For both strains, the control group showed a significantly higher (p<0.05) bacterial growth (1.5 x 108 CFU/mL), while the Dye group presented no significant reduction (p>0.05) in the CFU counts. The Dye/Laser group presented a significant decrease in the CFU counts (p<0.05) compared with the Control group (61.53% for A.a. and 84.32% for S.s.). It may be concluded that PDT was effective in reducing the numbers of A.a. and S.s. in vitro.

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Section: Discussionmentioning

confidence: 99%

In Vitro Effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans and Streptococcus sanguinis

et al. 2011

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“…One study 46 reported a triple blind method, while nine studies reported a double-blind method: de Assis et al, 32 Bortolluzy et al, 16 Botelho et al, 17 Calvo et al, 19 Faraco et al, 36 Guimarães et al, 47 Kogawa et al, 48 Rivera et al 68 and Vieira et al 86 Fifteen studies reported single blinding of the healthcare providers or outcome assessors. 10,23,25,27,28,30,31,33,37,39,44,46,50,58 In another 14 studies, the authors reported blinding but did not describe the method, or blinding was impossible. The studies by Gispert Abreu et al 41 and Gispert Abreu et al 42 were examples of the impossibility of blinding, because there was no report of any alternative treatment or placebo for the controls.…”

Section: Discussionmentioning

confidence: 99%

Assessing the risk of bias in randomized controlled trials in the field of dentistry indexed in the Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde) database

et al. 2011

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CONTEXT AND OBJECTIVE: Well-conducted randomized controlled trials (RCTs) represent the highest level of evidence when the research question relates to the effect of therapeutic or preventive interventions. However, the degree of control over bias between RCTs presents great variability between studies. For this reason, with the increasing interest in and production of systematic reviews and meta-analyses, it has been necessary to develop methodology supported by empirical evidence, so as to encourage and enhance the production of valid RCTs with low risk of bias. The aim here was to conduct a methodological analysis within the field of dentistry, regarding the risk of bias in open-access RCTs available in the Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde) database. DESIGN AND SETTING:This was a methodology study conducted at Universidade Federal de São Paulo (Unifesp) that assessed the risk of bias in RCTs, using the following dimensions: allocation sequence generation, allocation concealment, blinding, and data on incomplete outcomes. RESULTS:Out of the 4,503 articles classified, only 10 studies (0.22%) were considered to be true RCTs and, of these, only a single study was classified as presenting low risk of bias. The items that the authors of these RCTs most frequently controlled for were blinding and data on incomplete outcomes. CONCLUSION:The effective presence of bias seriously weakened the reliability of the results from the dental studies evaluated, such that they would be of little use for clinicians and administrators as support for decision-making processes.RESUMO CONTEXTO E OBJETIVO: Ensaios controlados randomizados (ECRs) bem conduzidos representam o mais alto nível de evidência quando a pergunta de pesquisa é sobre o efeito de intervenções terapêuticas ou preventivas. No entanto, o grau de controle de viés entre os ECRs apresenta grande variabilidade entre estudos. Por esta razão, com o aumento do interesse e produção das revisões sistemáticas e metanálises, foi necessário desenvolver metodologia suportada por evidência empírica, para incentivar e valorizar a produção de ECRs válidos e com baixo risco de viés.O objetivo deste trabalho foi realizar uma análise metodológica da área de odontologia quanto ao risco de viés de ECRs de acesso aberto, disponibilizados no banco de dados do Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde). TIPO DE ESTUDO E LOCAL:Trata-se de um estudo sobre metodologia conduzido na Universidade Federal de São Paulo (Unifesp) que avaliou o risco de viés dos ECRs, utilizando as seguintes dimensões: geração da sequência de alocação, sigilo da alocação, cegamento e dados sobre desfechos incompletos.RESULTADOS: Dos 4.503 artigos classificados somente 10 (0,22%) estudos foram considerados verdadeiros ECR e, destes, somente um estudo foi classificado como sendo de baixo risco de viés. Os itens mais frequentemente controlados pelos autores dos ECR foram cegamento e dados sobre desfechos incompletos.CONCLUSÃO: A presença efetiva de ...

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“…treatment of oral ulcers, 50 periodontal therapy, 51,52 cleaning of organic debris prior to application of pit and fissure sealants, 53 plaque removal 54 and root canal irrigation. 55 …”

Section: Other Uses Of Carisolvmentioning

confidence: 99%

Current update of chemomechanical caries removal methods

2014

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Chemomechanical caries removal is an excellent method for minimally invasive caries excavation, and the removal agents are either sodium hypochlorite (NaOCl)-or enzyme-based. The NaOCl-based agents include GK-101, GK-101E (Caridex) and Carisolv, and the enzyme-based agents include Papacarie and the experimental material, Biosolv. This review outlines the changes in chemomechanical caries removal methods and focuses on recently published laboratory and clinical studies. The historical development, mechanism of action, excavation time and biological effects on pulp and dental hard tissues are described. Based on existing evidence, the currently available chemomechanical caries removal methods are viable alternatives to conventional rotary instrument methods. Chemomechanical methods could be extremely useful in very anxious, disabled and paediatric patients. It does seem some of these agents would still benefit from quicker excavation times in order to achieve more universal acceptance. However, as a means of conserving the caries-affected dentine, chemomechanical caries removal is possibly much more successful than conventional rotary instrumentation.Keywords: Biosolv, Caridex, Carisolv, chemomechanical caries removal, minimal intervention dentistry, Papacarie.Abbreviations and acronyms: EDTA = ethylene diamine tetra-acetic acid; FDA = US Food and Drug Administration; NaOC1 = sodium hypochlorite; VAV = Visual Analogue and Verbal scale; WBFP = Wong Baker Faces Pain scale.

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Efficacy of Carisolv™ as an adjunctive therapy to scaling and root planing on subgingival calculus removal

Cited by 9 publications

References 17 publications

In Vitro Effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans and Streptococcus sanguinis

In Vitro Effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans and Streptococcus sanguinis

Assessing the risk of bias in randomized controlled trials in the field of dentistry indexed in the Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde) database

Current update of chemomechanical caries removal methods

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