À procura do Santo Graal: aonde vamos com os biomarcadores na sepse?

Dal‐Pizzol, Felipe

doi:10.1590/s0103-507x2012000200004

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…These markers can be divided into risk prediction, diagnosis, monitoring and outcome. ( 7,8 ) In this group of molecules, we can highlight the success of some, such as procalcitonin and CD14, ( 7,9 ) but they are costly and not feasible options for low- and middle-income countries, such as Brazil.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study

Martins

Silveira

Viégas

et al. 2019

Revista Brasileira De Terapia Intensiva

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Objective To evaluate the neutrophil-lymphocyte ratio as a predictor of sepsis and mortality in patients admitted to an intensive care unit. Methods Case-control study of adult patients admitted to an intensive care unit. Patients who had sepsis as the reason for admission and who had a previous complete blood count examination were included as case patients. The following statistical analyses were performed: ROC curves, binary logistic regression, and Mann-Whitney and Pearson's chi-square tests. p < 0.05 was considered significant. Results The ROC curve values were 0.62 for neutrophil-lymphocyte ratio, 0.98 for band neutrophils and 0.51 for total leukocytes. The presence of a neutrophil-lymphocyte ratio greater than 5.0, leukocyte count above 12,000mm 3 /mL and band neutrophil percentage above 10% were risk factors for sepsis; however, only the SAPS 3 and SOFA score were related to patient mortality. Conclusion The neutrophil-lymphocyte ratio and band neutrophils in combination with other parameters may be markers for the early detection of sepsis in intensive care units.

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Section: Introductionmentioning

confidence: 99%

Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study

Martins

Silveira

Viégas

et al. 2019

Revista Brasileira De Terapia Intensiva

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“…Sepsis is one of the main causes of mortality and extended length of stay in patients with urological infections, including Fournier gangrene [20] . To reduce the severity of the disease, utilization of cheap and simple laboratory parameters, such as white blood cell parameters, erythrocyte sedimentation rate, and C-reactive protein are necessary [21,22] . The use of NLR as a parameter has been suggested by many studies.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Role of Neutrophil-Lymphocyte Ratio in Fournier Gangrene Patients

Raizandha¹,

Hidayatullah²,

Kloping³

et al. 2021

IJRP

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Fournier gangrene is a rare type of necrotizing fasciitis which affects the perineal, genital, or anorectal region. It is considered as a urological emergency as it has a high mortality rate, at 20 to 50% in most reported series. Our aim was to evaluate the role of neutrophil-lymphocyte ratio as a prognostic marker for Fournier gangrene patients. There is an increasing interest in suggesting the correlation between inflammatory status and disease prognosis, one of the most commonly used parameter is the neutrophillymphocyte ratio (NLR). This is an analytical study with a retrospective approach evaluating the medical record data of patients diagnosed with Fournier gangrene admitted to Dr. Soetomo General Academic Hospital from January 2012 to November 2020. A total of 109 patients aged approximately 50.31 years old were included in this study. The average NLR of the patients was 15.86, indicating a high NLR compared to the ratio found in healthy people. The area under curve value was 0.65 (95% CI; 0,524-0,754; p < 0,05). The Kaplan-Meier curve in figure 2 showed that the NLR cut-off value of 10.9 has a significant impact on the patient's mortality rate (95% CI ; 29,7-19,7; p < 0,05). This study revealed that NLR can be used as an indicator of poor prognosis in FG patients with a cut-off point value of 10.9.

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Comparison of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for the diagnosis of neonatal sepsis: a systematic review and meta-analysis

et al. 2023

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Purpose To compare the performance of Neutrophil-to-Lymphocyte Ratio (NLR) with that of Platelet-to-Lymphocyte Ratio (PLR) in diagnosing neonatal sepsis (NS). Methods PubMed and Embase were searched for relevant studies from the inception of the databases to May, 2022. The pooled sensitivity (SEN), specificity (SPE), and area under the receiver operator characteristic curve (AUC) were measured. Results Thirteen studies involving 2610 participants were included. The SEN, SPE, and AUC of NLR were 0.76 (95%CI: 0.61–0.87), 0.82 (95%CI: 0.68–0.91), and 0.86 (95%CI: 0.83–0.89), respectively, and those of PLR were 0.82 (95%CI: 0.63–0.92), 0.80 (95%CI: 0.24–0.98), and 0.87 (95%CI: 0.83–0.89), respectively. Significant heterogeneity was observed among the studies. Subgroup analysis and meta-regression showed that types of sepsis (p = 0.01 for SEN), gold standard (p = 0.03 for SPE), and pre-set threshold (p<0.05 for SPE) might be the sources of heterogeneity for NLR, whereas the pre-set threshold (p<0.05 for SPE) might be the source of heterogeneity for PLR. Conclusions NLR and PLR would be of great accuracy for the diagnosis of NS, and the two indicators have similar diagnostic performance. However, the overall risk of bias was high, and significant heterogeneity was identified among the included studies. The results of this study should be interpreted prudently, and the normal or cut-off values and the type of sepsis should be considered. More prospective studies are needed to further support the clinical application of these findings.

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À procura do Santo Graal: aonde vamos com os biomarcadores na sepse?

Cited by 3 publications

References 5 publications

Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study

Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study

The Prognostic Role of Neutrophil-Lymphocyte Ratio in Fournier Gangrene Patients

Comparison of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for the diagnosis of neonatal sepsis: a systematic review and meta-analysis

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