Padrões de utilização de antibacterianos em unidades de terapia intensiva

Santos, Edilson Floriano dos; Lauria-Pires, Liana

doi:10.1590/s0103-507x2010000200008

Cited by 10 publications

(10 citation statements)

References 23 publications

(29 reference statements)

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“…(19) In a study performed at a general ICU in Recife (Pernambuco, Brazil), antibacterials were also the most widely used therapeutic class, followed by antihypertensives/antiarrhythmics, antacids, anxiolytics/ sedatives/hypnotics and analgesics/antipyretics. (17) The therapeutic classes most commonly used among antibacterials differed from the results of Santos et al (21) in a study conducted in three ICU in Brasilia (Federal District, Brazil) once, in Campo Grande (Mato Grosso do Sul, Brazil), it was observed a higher frequency of prescriptions of antibacterials to resistant microorganisms, such as carbapenems, glycopeptides and polymyxins.…”

Section: Discussionmentioning

confidence: 91%

Caracterização das prescrições medicamentosas em unidade de terapia intensiva adulto

Cardinal¹,

Matos²,

Resende³

et al. 2012

Rev. bras. ter. intensiva

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Section: Discussionmentioning

confidence: 91%

Caracterização das prescrições medicamentosas em unidade de terapia intensiva adulto

Cardinal¹,

Matos²,

Resende³

et al. 2012

Rev. bras. ter. intensiva

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“…The utilization metrics found in this review were DDD/bed-days in 4 studies, DDD/patient-days in 8, and DDD/100 admissions in 1. Among these, two presented antibiotic consumption data arising from multiple locations (three for dos Santos et al, 2010 22 ) and more than one treatment (two for Gimenes et al 2016 29 ), totaling 16 columns as shown in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

Antibiotic use in Brazilian hospitals in the 21st century: a systematic review

Pereira

Zanetti

Sponchiado

et al. 2021

Rev. Soc. Bras. Med. Trop.

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Introduction: This systematic review aimed to assess antibiotic use in Brazilian hospitals in the 21st century, as well as to understand the different drug utilization metrics adopted to assess the consumption of these drugs. Methods: We systematically reviewed five databases (MEDLINE [Medical Literature Analysis and Retrieval System Online], CENTRAL [The Cochrane Central Register of Controlled Trials], EMBASE® [Excerpta Medica Database], Scopus [Elsevier's abstract and citation database], and LILACS [Literatura Latino-Americana e do Caribe em Ciências da Saúde]) for observational or experimental studies that assessed antibiotic utilization in Brazilian hospitals. The main outcomes were the drug utilization metrics and the consumption of antibiotics. Results: We included 23 studies, of which 43.5% were carried out in adult and pediatric care units, 39.1% in adult units, and 17.4% in pediatric units. Regarding the complexity of healthcare, 26.1% of the studies were performed in intensive care units. Two drug utilization metrics were used in these studies: the defined daily dose (DDD) and the percentage of antibiotic prescriptions. The most commonly used antibiotic classes were third-generation cephalosporins, carbapenems, fluoroquinolones, and combinations of penicillins when the DDD was the adopted drug utilization metric. Conclusions: Although few studies have been conducted, existing data indicate a high use of broad-spectrum antibiotics. We found that the lack of standardized antibiotic utilization metrics impaired the mapping of drug consumption at the national level.

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“…[12] A study in Brazil also showed similar antimicrobialusage patterns, with high cephalosporin prescription. [27] Such high cephalosporin usage may simply be explained by the fact that there is greater familiarity with the drug, and represents choice based on physician preference rather than being evidence based.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of microbial growth and antimicrobial usage in an intensive-care unit of a tertiary-care hospital in Trinidad, West Indies

2017

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Background. Intensive-care units (ICUs) are a source of multidrug-resistant organisms, owing to the indiscriminate usage of broad-spectrum antimicrobial drugs. In such settings, one must be aware of the spectrum of microbes and pattern of antibiotic usage. Objectives. To evaluate the spectrum, susceptibility and resistance patterns of microbes found in ICU patients in a tertiary-care teaching hospital in Trinidad, and to quantify antimicrobial usage. Methods. All adult patients (≥15 years of age) admitted to the ICU for ≥48 h who developed nosocomial infections conforming to the Centers for Disease Control and Prevention criteria were included. Demographic data and clinical data, including specimens sent, isolates grown, antimicrobial sensitivity and resistance patterns, the usage of antimicrobials and patient outcomes, were recorded. Variables such as age, admission white blood cell count, duration of first antibiotic used, length of ICU stay, length of hospital stay, organ support and total comorbidities were analysed. Antimicrobial usage was quantified as the defined daily dosage per 1 000 patient-days. Results. A total of 153 patients with 287 microbiological specimens were studied. The mean patient age was 48.4 years, and the mean ICU length of stay was 7.9 days. The most common admitting diagnoses were sepsis and multiple trauma. Staphylococcus aureus was the most common isolate from blood and central venous lines, and Pseudomonas aeruginosa from tracheal aspirates and wound swabs. Non-survivors had significantly higher age, leucocyte count and organ support requirements, and shorter lengths of stay. Cefuroxime was the most-used antimicrobial in the unit. Conclusion. The usage pattern of antimicrobials did not correlate with susceptibility in most instances. There is a need to improve antimicrobial usage by implementing antimicrobial-stewardship programmes to establish an antimicrobial protocol and guidelines for usage in the ICU.

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Padrões de utilização de antibacterianos em unidades de terapia intensiva

Cited by 10 publications

References 23 publications

Caracterização das prescrições medicamentosas em unidade de terapia intensiva adulto

Caracterização das prescrições medicamentosas em unidade de terapia intensiva adulto

Antibiotic use in Brazilian hospitals in the 21st century: a systematic review

Spectrum of microbial growth and antimicrobial usage in an intensive-care unit of a tertiary-care hospital in Trinidad, West Indies

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