Three new labdanes isolated from Eragrostis viscosa

Sebastião, N’Soki N.; Fernandes, Nelson António Freitas; Vieira, Liliana; Mendonça, António; Gaspar, Jorge; Martins, Célia; Rueff, José; Diakanamwa, Carlos; Mendonça, Dina I.M.D. de

doi:10.1590/s0103-50532012005000067

Cited by 5 publications

(8 citation statements)

References 7 publications

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“…192 Phyllanthus polyanthus (Phyllanthaceae) also known as Forest Potato-bush is a rare species of plant in South Africa. 194 Ndlebe et al isolated two new triterpenoids phyllanthol (109), phyllanthone (110) in addition to the known compounds (20S)-3b-acetoxy-24-methylenedammaran-20-ol (111), and (20S)-3a-acetoxy-24-methylenedammaran-20-ol (112), lupenone (113), d-amyrin acetate (114) from the stem bark and leaves of this plant. 194 Ndlebe et al isolated two new triterpenoids phyllanthol (109), phyllanthone (110) in addition to the known compounds (20S)-3b-acetoxy-24-methylenedammaran-20-ol (111), and (20S)-3a-acetoxy-24-methylenedammaran-20-ol (112), lupenone (113), d-amyrin acetate (114) from the stem bark and leaves of this plant.…”

Section: Pentacyclic Triterpenoidsmentioning

confidence: 99%

“…Phytochemical investigation of the toluene and dichloromethane extracts of the aerial parts of this plant by Sebastião et al afforded three new 8a,15-epoxylabdanes namely; methyl 8a,15-epoxylabdan-16b-oate (43), 8a,15-epoxylabdan-16b-ol (44), 8a,15-epoxy-16-norlabdan-13b-ol (45) together with other known compounds. 109 Some of the known compounds in this class include 8a,15-epoxy-16norlabdan-13-one ( 46), 8a,15-epoxylabdan-16b-oic acid (47) and 16-acetoxy-8a,15-epoxylabdane (48). The genotoxicity of the compounds isolated from this plant was studied using a cytokinesis-block micronucleus assay and the Ames test was also used to assess mutagenicity.…”

Section: Labdane-type Diterpenesmentioning

confidence: 99%

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The chemistry and bioactivity of Southern African flora I: a bioactivity versus ethnobotanical survey of alkaloid and terpenoid classes

et al. 2015

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As a whole, the African continent is highly endowed with a huge floral biodiversity. Natural products which have been isolated from plants growing in this region have shown interesting chemical structures with diverse biological activities, which could serve as a starting point for drug discovery. In this study, a literature survey led to the collection of 864 secondary metabolites from 101 plant species from 57 plant families. A correlation between the known biological activities of isolated compounds and the ethnobotanical uses of the plants has been attempted. This review is a survey of the bioactivities of alkaloids and terpenoids which have been isolated from Southern African flora versus the ethnobotanical uses of the plants used in Southern African traditional medicine.

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Section: Pentacyclic Triterpenoidsmentioning

confidence: 99%

Section: Labdane-type Diterpenesmentioning

confidence: 99%

The chemistry and bioactivity of Southern African flora I: a bioactivity versus ethnobotanical survey of alkaloid and terpenoid classes

et al. 2015

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“…Previous studies of allelochemicals of E. plana have already led to the identification of several compounds, such as pimarane, cassane (Nishiya et al 1991), norlabdane (Sebastião et al 2010), labdane (Sebastião et al 2012) and neocassane (Favaretto et al 2019). However, species synthetize and release a variety of components which are influenced by environmental factors and determine modifications in the spectrum of produced substances.…”

Section: Introductionmentioning

confidence: 99%

Phytotoxic bioassays and Fingerprinting by HPLC-DAD of Eragrostis plana Nees Root Extracts – application of chemometrics

Hendges

Teixeira

Lima

et al. 2021

An. Acad. Bras. Ciênc.

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Eragrostis plana (Nees) (Tough Lovegrass) shows ability to interfere with other plants, a phenomenon known as allelopathy. This chemical interaction between plants occurs due to the release of compounds into the environment. Thus, a phytotoxicity study was carried out with E. plana roots collected during each season throughout the year, and the compounds were extracted with solvents of increasing polarity. The data from the bioassays were analyzed by GLM and PCA. In addition, a fi ngerprint of these extracts was obtained by HPLC-DAD. The extracts in petroleum ether from roots collected in the winter and summer showed greater phytotoxicity on Ipomoea grandifolia germination and growth. The PCA obtained from the chromatogram of the crude extract showed that the extracts in petroleum ether were chemically different from the extracts in ethyl acetate and methanol. Thus, continuing this study in order to develop a new generation of bio-herbicides is essential.

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“…Trin., labdane were isolated (Sebastião et al, 2010;Sebastião et al, 2012), class of compounds with already …”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of leaf and root extracts of tough lovegrass

et al. 2017

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This study aimed to evaluate tough lovegrass leaf and root extracts antimicrobial activity. The extracts (plant material: solvent, 1:10) were prepared by maceration with methanol:water (1:1) during ten days followed by a concentration in a rotary evaporator under reduced pressure. The extracts were resuspended in water containing 1% of dimethylsulfoxide (DMSO) to obtain a final concentration of 100 mg/mL and then filtered through a sterilizing membrane with 0.22μm. The antibacterial activity of the leaf and root extracts were evaluated against pathogenic and phytopathogenic bacteria by agar well diffusion and microdilution broth methods for the minimum inhibitory concentrations (MIC) determination. The antifungal activity of tough lovegrass leaf and root extracts were evaluated by micelial growth inhibition and conidial germination inhibition. The extracts presented low antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Xanthomonas translucens, but the leaf extracts presented significant antifungal activity against the phytopathogenic fungus Drechslera tritici-repentis. The results support the continuity of the study in improving the effectiveness of the active extract for a possible use in pharmacology and agronomy and in attempting to determine the probable active antimicrobial compound. Keywords: antibacterial activity, antifungal properties, Eragrostis plana, phenolic compounds Atividade antimicrobiana de extratos foliares e radiculares de capim annoni ResumoEste estudo teve como objetivo avaliar a atividade antimicrobiana dos extratos foliares e radiculares radiculares do capim-annoni. Os extratos (material vegetal: solvente 1:10) foram preparados por maceração com metanol: água (1: 1) durante dez dias seguido de concentração em evaporador rotatório sob pressão reduzida. Os extratos foram ressuspendidos em água contendo 1% de dimetil sulfóxido (DMSO) para obter uma concentração final de 100 mg / mL e depois filtrados através de uma membrana esterilizante de 0,22 um. A atividade antibacteriana dos extratos foliares e radiculares foi avaliada contra bactérias patogênicas e fitopatogênicas por meio de técnicas de difusão em ágar pelo método dos poços e microdiluição em caldo para a determinação das concentrações inibitórias mínimas (MIC). Avaliou -se a atividade antifúngica de extratos de folhas e raízes de capim-annoni resistentes por inibição do crescimento micelial e inibição da germinação conidial. Os extratos apresentaram baixa atividade antibacteriana contra Staphylococcus aureus, Staphylococcus epidermidis e Xanthomonas translucens, porém os extratos foliares apresentaram atividade antifúngica significativa contra o fungo fitopatogênico Drechslera tritici-repentis. Os resultados apoiam a continuidade do estudo na melhoria da eficácia do extrato ativo para um possível uso em farmacologia e agronomia e na tentativa de determinar o provável composto antimicrobiano ativo Palavras-chave: atividade antibacteriana, propriedades antifúngicas, Eragrostis plana, composto...

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Three new labdanes isolated from Eragrostis viscosa

Cited by 5 publications

References 7 publications

The chemistry and bioactivity of Southern African flora I: a bioactivity versus ethnobotanical survey of alkaloid and terpenoid classes

The chemistry and bioactivity of Southern African flora I: a bioactivity versus ethnobotanical survey of alkaloid and terpenoid classes

Phytotoxic bioassays and Fingerprinting by HPLC-DAD of Eragrostis plana Nees Root Extracts – application of chemometrics

Antimicrobial activity of leaf and root extracts of tough lovegrass

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