Eragrostis plana (Nees) is an allelopathic plant
with invasive potential in South American pastures. To isolate and
identify phytotoxic compounds from leaves and roots of E.
plana, a bioassay-directed isolation of the bioactive constituents
was performed. This is the first report on a new diterpene carbon
skeleton, neocassane, and of three new neocassane diterpenes, neocassa-1,12(13),15-triene-3,14-dione, 1; 19-norneocassa-1,12(13),15-triene-3,14-dione, 2; and 14-hydroxyneocassa-1,12(17),15-triene-3-one, 3, identified from the roots. Compounds 1, 2, and 3 inhibited the growth of duckweed by 50% at concentrations
of 109 ± 28, 200 ± 37, and 59 ± 15 μM, respectively.
Compound 2 was fungicidal to Colletotrichum fragariae, Colletotrichum acutatum, and Colletotrichum
gloeosporioides. The compounds identified here could explain
the allelopathy of E. plana. The description of the
newly discovered compounds, besides contributing to the chemical characterization
of the species, may be the first step in the study of the potential
of these compounds as bioherbicides.