Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water

Cardoso, Leandro Lunardini; Tomasini, Débora; Sampaio, Maicon R. F.; Caldas, Sergiane Souza; Kleemann, Natiele; Prímel, Ednei Gilberto; Gonçalves, Fábio Ferreira

doi:10.1590/s0103-50532011001000016

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…Matrix effect was performed by comparison between calibration curves prepared in pure methanol and in tomato matrix extract. The signal suppression/enhancement (C %) found in this experiment was -2.43%, located in the range -20% < C % < 20% (Cardoso, 2011) indicating that the matrix effect was not significant. For stability, the values of percentage deviation in the peak response from initial data were located in the acceptance criteria ranged from -20% to 10% (VICH, 2011) so propamidine was found to be stable in methanol and in tomato extract solution in freezer, room temperature and oven condition for the period of 14 days (period of essay).…”

Section: Validamentioning

confidence: 57%

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Dissipation of Propamidine Fungicide Residues in Greenhouse Tomato

Kansaye¹,

Zhang²,

Wu³

et al. 2013

JAS

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A method of reverse phase high performance liquid chromatography (RP-HPLC) was established to analyze the dissipation of propamidine residue in tomato. Residue of propamidine was extracted from tomato using methanol buffered and determined by RP-HPLC with UV detection at 262 nm. The results showed that the average recoveries of the samples fortified with propamidine at the concentration range of 25 to 300 mg kg^-1 ranged from 87.972 to 106.341% with a relative standard deviation ranged between 0.169 to 3.503%. Initial deposit ranged from 2.45 to 5.70 mg kg^-1. The dissipation of propamidine in tomato followed the first order kinetic equation. The dissipation rate constants in tomato treated with recommended and double recommended dose applied at 4 times and 2 times ranged from 0.110 to 0.151 days, and the corresponding half-lives from 4.589 to 6.300 days. At the day 14 after the last application the residue concentrations of propamidine in tomato ranged from 0.42 to 0.54 mg kg^-1from the two blocks for all treatments. These propamidine residues dissipated below the limit of detection of 0.07 mg kg^-128 days after the last treatment. The results presented in this work and the low toxicity of propamidine for environment proved that propamidine will not pose any residual toxicity problem after 14 days of application and tomato fruits could be used safely for human consumption.

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Section: Validamentioning

confidence: 57%

“…Matrix effect was performed by comparison between calibration curves prepared in pure methanol and methanol containing tomato extract prepared as described above. Calculation was made using the following equation used by Cardoso et al (2011).…”

Section: Validation Methodsmentioning

confidence: 99%

Dissipation of Propamidine Fungicide Residues in Greenhouse Tomato

Kansaye¹,

Zhang²,

Wu³

et al. 2013

JAS

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“…APCI mode experienced less ME especially for non-polar and steroid compounds compared to ESI mode [5,42,43]. This is beneficial when quantifying environmental matrices.…”

Section: 332mentioning

confidence: 99%

Simultaneous extraction and determination of pharmaceuticals and personal care products (PPCPs) in river water and sewage by solid-phase extraction and liquid chromatography-tandem mass spectrometry

Tan

Zakaria

Latif

et al. 2015

International Journal of Environmental Analytical Chemistry

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“…3 They can enter the environment as isolated compounds or metabolites, conjugates, or both. 4 Contamination of the environment can occur by the use of animal manure and effluent treatment sludge containing veterinary drug residues as fertilizer. Other sources of contamination include waste treatment lagoons improperly constructed, which the contaminants may be leaked or leached from waste into surface water and groundwater.…”

Section: Introductionmentioning

confidence: 99%

Adsorptive Stripping Voltammetric Determination of Oxolinic Acid in Water Sample

Aleixo¹,

Okumura²,

Silva³

et al. 2018

J. Braz. Chem. Soc.

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One new methodology for analysis of the antimicrobial oxolinic acid (OXA) based on adsorptive stripping voltammetry (AdSV) in carbon paste electrode (CPE) was developed and applied in untreated pond water sample. Cyclic voltammetry (CV) indicated that an irreversible anodic process occurs in KOH solution as supporting electrolyte. Quantification of the antimicrobial was carried out by differential pulse adsorptive stripping voltammetry (DPAdSV) at potential of deposition (E D ) +1.05 V for 45 s to examine OXA adsorption on the surface of CPE. The limits of detection (LOD) and quantification (LOQ) of the method for OXA analysis were determined. The values of LOD were 0.0570 and 0.512 mg L -1 in absence of matrix and in the water sample, respectively, and the corresponding values of LOQ were 0.192 and 1.707 mg L -1 , respectively. The apparent recovery percentage for different concentrations of OXA in natural waters ranged between 98.4 and 109%.

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Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water

Abstract: Neste trabalho, foi desenvolvido e validado um método analítico baseado na extração em fase sólida (SPE) e cromatografia líquida acoplada a espectrometria de massas em tandem (LC-APCI-MS/MS) para a determinação e confirmação de cinco fármacos em amostras de água.

Cited by 12 publications

References 16 publications

Dissipation of Propamidine Fungicide Residues in Greenhouse Tomato

Dissipation of Propamidine Fungicide Residues in Greenhouse Tomato

Simultaneous extraction and determination of pharmaceuticals and personal care products (PPCPs) in river water and sewage by solid-phase extraction and liquid chromatography-tandem mass spectrometry

Adsorptive Stripping Voltammetric Determination of Oxolinic Acid in Water Sample

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