Total synthesis of (-)-basiliskamide A and NMR studies on the conversion of basiliskamide A to basiliskamide B

Abstract

Descrevemos neste trabalho nossa rota sintética para obtenção do policetídeo antifúngico (-)-basiliskamida A, assim como estudos de RMN de 1 H relacionados a migração da cadeia lateral cinamoíla da basiliskamida A para formar a basiliskamida B em CDCl 3 .We describe herein our approach to the total synthesis of the antifungal polyketide (-)-basiliskamide A, as well as 1 H NMR studies on the migration of the cinnamoyl side chain of basiliskamide A to form basiliskamide B in CDCl 3 solution.

Multi-gram-scale synthesis of a versatile syn-anti stereotriad by a short and cost-effective route

“…We imagine that synthon (1a) may be incorporated into large polyketides through easily performed transformations. [34][35][36][37][38][39][40]…”