Synthesis of hydroxy acids of dinorcholane and 5β-cholane

Abstract

Uma mistura diastereomérica (55:45) de 3-oxo-23,24-dinorcol-4-en-22-hydroxi ácidos (4A e 4B) foi sintetizada a partir de 3-oxo-23,24-dinorcol-4-en-22-al (1) em 3 etapas. Similarmente, 3-oxo-5β-cholano-24-hidroxi ácido (9) foi sintetizado a partir de 5β-cholano-3α,24-diol (5) em 4 etapas. Dados espectroscópicos completos para estes compostos são apresentados.A diastereomeric mixture (55:45) of 3-oxo-23,24-dinorchol-4-en-22-hydroxy acids (4A and 4B) was synthesized from 3-oxo-23,24-dinorchol-4-en-22-al (1) in 3 steps. Similarly, 3-oxo-5β-cholane-24-hydroxy acid (9) was synthesized from 5β-cholane-3α,24-diol (5) in 4 steps. Full spectroscopic data for these compounds are presented.