Electrochemical reduction and voltammetric determination of diloxanide furoate in non-aqueous medium

Santos, André Luíz dos; Takeuchi, Regina M.; Stradiotto, Nelson Ramos

doi:10.1590/s0103-50532005000600006

Cited by 4 publications

(3 citation statements)

References 4 publications

(5 reference statements)

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“…1A, the absence of cathodic peaks in the reverse scan suggests that TCC oxidation involves irreversible electron-transfer or that the process at the electrode is complicated by a coupled chemical reaction. 34 For both processes, the current function (I p /v 1/2 ) decreased with the scan rate, indicating the absence of a coupled chemical reaction (inset of Fig. 1A).…”

Section: Resultsmentioning

confidence: 90%

Determination of triclocarban by direct and adsorptive stripping voltammetric methods on a glassy carbon electrode

et al. 2015

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Section: Resultsmentioning

confidence: 90%

Determination of triclocarban by direct and adsorptive stripping voltammetric methods on a glassy carbon electrode

et al. 2015

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“…Peak potential shift of more than 30 mV upon tenfold increase in scan rate suggests an irreversible electron transfer reaction as reported in literature. 37 The peak current was plotted against the square root of scan rate (υ 1/2 ) for the calculation of diffusibility constant using the Randles Sevcik equation; 38 I p = 2.99 × 10 5 n(an a ) 1/2 AC D 1/2 ν 1/2 [3] In Eq. 3, "n" represents the number of electrons involved in the oxidation process, "α a " denotes the charge transfer coefficient, while "D", "C" and "A" stand for the diffusibility constant (cm s −1 ), analyte bulk concentration (mol cm −3 ) and electro-sensing surface (cm −2 ) of the GCE respectively.…”

Section: Cyclic Voltammetry (Cv)mentioning

confidence: 99%

pH and Temperature Responsive Electrooxidation and Antioxidant Activity of Indole-3-Carbaldehyde

Subhan

Ahmad

Lashin

et al. 2016

J. Electrochem. Soc.

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Inspired by the broad range activities of indoles, we explored the antioxidant and electrochemical behavior of indole-3-carbaldehyde (I3C). The compound was first tested for cytotoxicity followed by the evaluation of its antioxidant activity using thiobarbituric acid-reactive species (TBARs). The selected indole was then investigated by several voltammetric techniques to gain insights about proposing its antioxidant action mechanism. Kinetics of the electrode reaction was probed by cyclic voltammetry experiments, which led to the determination of diffusibility constant and heterogeneous electron transfer rate constant. The feasibility of the redox event of 13C was judged from the thermodynamic parameters evaluated by observing the influence of temperature on the anodic response of the analyte. Square wave voltammetry (SWV) was employed for ensuring the reversible or irreversible nature of the oxidation reaction of I3C. Differential pulse voltammetry (DPV) was applied for the determination of number of electrons and protons involved in oxidation of the analyte. Moreover, DPV and SWV were used for the sensitive detection of I3C at bare and gold nanoparticles modified glassy carbon electrode. On the basis of voltammetric findings an oxidation mechanism supported by computational results was proposed with the objective of unravelling the antioxidant behavior of a representative of indoles.

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“…Recently, our group has studied the electrochemical reduction of diloxanide furoate on glassy carbon electrode in acetonitrile medium. 24 We have observed that electrochemical reduction of diloxanide furoate involves the C-Cl bond cleavage and the electrochemical techniques can be successfully employed for its quantification.…”

Section: Introductionmentioning

confidence: 99%

Study of the electrochemical reduction of amoebicide teclozan and its amperometric determination in pharmaceutical formulations

Santos¹,

Takeuchi²,

Stradiotto³

et al. 2008

J. Braz. Chem. Soc.

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Neste trabalho, a redução eletroquímica do amebicida Teclozan (TEC) foi estudada sobre um eletrodo de carbono vítreo em meio de acetonitrila. Eletrólises com potencial controlado foram realizadas visando, tanto a determinação do número de elétrons envolvidos na redução do fármaco, quanto a identificação dos produtos eletrogerados, os quais foram isolados por extração líquido-líquido e caracterizados por 1 H RMN. Foi verificado que o TEC apresenta dois picos voltamétricos, cada um associado à quebra redutiva de duas ligações C-Cl. Em presença de um doador de prótons, foi observado que o primeiro pico voltamétrico em −1,8 V corresponde principalmente à redução dos grupamentos -CHCl 2 a -CH 2 Cl; enquanto o segundo pico em −2,2 V é responsável pela redução dos grupos -CH 2 Cl a CH 3 , fornecendo como único produto o derivado totalmente desalogenado do TEC, com rendimentos entre 82 e 97%. Este trabalho descreve também o desenvolvimento de um método eletroanalítico baseado na detecção amperométrica do TEC em condições hidrodinâmicas, o qual forneceu um limite de detecção de 8,9 × 10 -6 mol L -1 .The electrochemical reduction of amoebicide Teclozan (TEC) was studied on a glassy carbon electrode in acetonitrile. Controlled-potential electrolyses were performed for coulometric and preparative purposes. The electrogenerated products were isolated by liquid-liquid extraction and characterized by 1 H NMR. It was observed that TEC presents two voltammetric peaks, each one associated with the cleavage of two C-Cl bonds. In presence of a proton donor it was observed that the first peak at −1.8 V promotes mainly the reduction of the groups CHCl 2 to CH 2 Cl and the second one at −2.2 V promotes the reduction of the groups CH 2 Cl to CH 3 giving as the sole product the completely dechlorinated TEC derivative with yields between 82 and 97%. In addition, a comparative study between the analytical performance of voltammetric techniques and amperometric detection of TEC in hydrodynamic conditions was performed. The amperometric detection was more sensitive than all evaluated voltammetric techniques, providing a detection limit of 8.9 × 10 -6 mol L -1 .

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Electrochemical reduction and voltammetric determination of diloxanide furoate in non-aqueous medium

Cited by 4 publications

References 4 publications

Determination of triclocarban by direct and adsorptive stripping voltammetric methods on a glassy carbon electrode

Determination of triclocarban by direct and adsorptive stripping voltammetric methods on a glassy carbon electrode

pH and Temperature Responsive Electrooxidation and Antioxidant Activity of Indole-3-Carbaldehyde

Study of the electrochemical reduction of amoebicide teclozan and its amperometric determination in pharmaceutical formulations

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