Estudo in vitro de sistemas bioadesivos para liberação sustentada de fluoreto

Garcia, Antonio Luengo; Lara, Elza Helena Guimarães; Panzeri, Heitor

doi:10.1590/s0103-06631998000200009

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…The polymeric device used in this work (modified from Garcia et al, 1998), was obtained employing HPMC (hydroxypropyl metyl cellulose) + Cp (Carbopol 934™ ) + StMg (magnesiun stearate) and NaF (sodium fluoride) as an active compound. A hydraulic press machine model C/12 (Fred S. Carver Inc.), with 5.5mm punction, was employed to obtain the polymeric devices, with 1.5 tons compression.…”

Section: Methodsmentioning

confidence: 99%

In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive

Pedrazzi¹,

Lara²,

Panzeri³

et al. 2009

Int. J. Morphol.

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SUMMARY:The intra-buccal polymeric bioadhesive systems that can stay adhered to the oral soft tissues for drug programmed release, with the preventive and/or therapeutic purpose has been employed for large clinical situations. A system based on hydroxypropyl methyl cellulose/Carbopol 934'/magnesium stearate (HPMC/Cp/StMg) was developed having the sodium fluoride as active principle. This kind of system was evaluated according to its resistance to the removal by means of physical test of tensile strength. Swine buccal mucosa extracted immediately after animals' sacrifice was employed as substrate for the physical trials, to obtain 16 test bodies. Artificial saliva with or without mucin was used to involve the substrate/bioadhesive system sets during the trials. Artificial salivas viscosity was determined by means of Brookfield viscometer, showing the artificial saliva with mucin 10.0 cP, and the artificial saliva without mucin 7.5 cP. The tensile strength assays showed the following averages: for the group "artificial saliva with mucin" -12.89 Pa, and for the group "without mucin" -12.35 Pa. Statistical analysis showed no significant difference between the assays for both artificial salivas, and it was possible to conclude that the variable mucin did not interfered with the bioadhesion process for the polymeric devices. The device was able to release fluoride in a safe, efficient and constant way up to 8 hours.

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Section: Methodsmentioning

confidence: 99%

In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive

Pedrazzi¹,

Lara²,

Panzeri³

et al. 2009

Int. J. Morphol.

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Mucoadhesive and mucus-penetrating polymers for drug delivery

Bruschi

Ferreira

Silva

2020

Nanotechnology for Oral Drug Delivery

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Oral Bioadhesive Drug Delivery Systems

Bruschi

Freitas

2005

Drug Development and Industrial Pharmacy

109

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The oral mucosal cavity is a feasible, safe, and very attractive site for drug delivery with good acceptance by users. The mucosa is relatively permeable and robust, shows short recovery times after stress or damage, is tolerant to potential allergens, and has a rich blood supply. Moreover, oral mucosal drug delivery bypasses the first-pass effect and avoids presystemic elimination in the gastrointestinal tract. Bioadhesive systems provide intimate contact between a dosage form and the absorbing tissue, which may result in high concentration in a local area and hence high drug flux through the absorbing tissue. The efficacy of oral bioadhesive drug delivery systems is affected by the biological environment and the properties of the polymer and the drug. In the present paper, we review systematically some relevant citations regarding the environment, strategies for oral drug delivery and evaluation, and utilization of the main polymers.

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Estudo in vitro de sistemas bioadesivos para liberação sustentada de fluoreto

Cited by 4 publications

References 4 publications

In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive

In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive

Mucoadhesive and mucus-penetrating polymers for drug delivery

Oral Bioadhesive Drug Delivery Systems

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