Oral Bioadhesive Drug Delivery Systems

Abstract

The oral mucosal cavity is a feasible, safe, and very attractive site for drug delivery with good acceptance by users. The mucosa is relatively permeable and robust, shows short recovery times after stress or damage, is tolerant to potential allergens, and has a rich blood supply. Moreover, oral mucosal drug delivery bypasses the first-pass effect and avoids presystemic elimination in the gastrointestinal tract. Bioadhesive systems provide intimate contact between a dosage form and the absorbing tissue, which may result in high concentration in a local area and hence high drug flux through the absorbing tissue. The efficacy of oral bioadhesive drug delivery systems is affected by the biological environment and the properties of the polymer and the drug. In the present paper, we review systematically some relevant citations regarding the environment, strategies for oral drug delivery and evaluation, and utilization of the main polymers.

Preparation and Evaluation of Poly-Butylcyanoacrylate Nanoparticles for Oral Delivery of Thymopentin

“…The fragile drugs can be encapsulated into polymeric nanoparticles and thus go through the GI tract. [11][12][13][14][15][16] Poly-butylcyanoacrylate (PBCA) is such a fine biodegradable polymer that has been used as surgery glue in clinic. [17][18][19][20][21][22][23] In addition, the former experiments done in our lab showed that the method to produce PBCA nanoparticles was much easier than the others.…”

Mini Tablets: A Short Review-Revision

“…It is possible to obtain local and systemic effect by using mucoadhesive systems. They allow the drug to remain in the area of action for a long time, thereby providing the local effect due to increase the duration of the absorption in the absorption zone [51,52]. Mucoadhesive polymers can adhere to the surface of the gastric mucosa, thus allowing the drug to remain in this area for a longer period of time, thereby increasing bioavailability [53].…”

Plataformas bio(muco)adesivas poliméricas baseadas em nanotecnologia para liberação controlada de fármacos propriedades, metodologias e aplicações

“…A mucosa mais utilizada para administração e absorção de fármacos é a gastrintestinal, mas outras membranas ou mucosas também têm sido estudadas, como a cutânea, nasal, ocular, bucal, vaginal, retal, oral e periodontal [10][11][12][13][14][15][16][17][18][19][20][21] . A função do muco é proteger e lubrificar o epitélio para evitar que micro-organismos e substâncias sejam absorvidos.…”