Tissue sulfomucin and sialomucin content in colon mucosa without intestinal transit subjected to intervention with Curcuma longa (curcumin)

Júnior, Antônio José Tibúrcio Alves; Pereira, José Aires; Pansani, Adrieli Heloísa Campardo; Magro, Daniéla Oliveira; Coy, Cláudio Saddy Rodrigues

doi:10.1590/s0102-865020170030000002

Cited by 12 publications

(4 citation statements)

References 26 publications

(44 reference statements)

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“…Although the sialomucins are the subtype of acid mucin that presents the greatest reduction of its contents in colonic mucosa excluded from fecal stream, the tissue content of sialomucins was always higher in animals treated with MEZ when compared with those treated with saline. These same results were found by other authors who used enemas with antioxidant substances in the mucosa devoid of fecal stream 29 , 30 . Taken together, all these results suggest that the tissue content of both acidic mucin subtypes increases with the regular supply of SCFAs and with the reduction of tissue oxidative stress.…”

Section: Discussionsupporting

confidence: 88%

“…Thus, the regular supply of SCFAs protects the mucus layer that covers the colonic epithelium by two different mechanisms: stimulating the production of mucins by the goblet cells and reduce its damage by oxidative stress 13 , 19 . The influence of oxidative stress in reduction of the tissue content of neutral and acid mucins appear to be confirmed by experimental studies 27 - 29 . They showed that the application of enemas containing sucralfate or curcumin an antioxidant substance in colonic mucosa without fecal stream, in addition to reduce the oxidative stress and improve the inflammatory process, increased the tissue content of neutral and acidic mucins 27 - 29 .…”

Section: Discussionmentioning

confidence: 94%

“…Experimental studies evaluated the effects of oxidative stress and substances with antioxidant properties on the tissue content of neutral an acidic mucins in the colonic mucosa with and without fecal stream 16 , 17 , 27 - 29 . The results showed that in colonic mucosa with fecal stream (provide of the regular supply of SCFAs) the tissue content of both types of mucins do not change along of colonic mucosa 16 .…”

Section: Discussionmentioning

confidence: 99%

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Enemas with mesalazine increase the tissue contents of mucins in the colonic mucosa devoid of fecal stream

et al. 2019

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Purpose: To evaluate the inflammatory reaction and measure the content of mucins, in the colonic mucosa without fecal stream submit to intervention with mesalazine. Methods: Twenty-four rats were submitted to a left colostomy and a distal mucous fistula and divided into two groups according to euthanasia to be performed two or four weeks. Each group was divided into two subgroups according daily application of enemas containing saline or mesalazine at 1.0 g/kg/day. Colitis was diagnosed by histological analysis and the inflammatory reaction by validated score. Acidic mucins and neutral mucins were determined with the alcian-blue and periodic acid of Schiff techniques, respectively. Sulfomucin and sialomucin were identified by high iron diamine-alcian blue technique. The tissue contents of mucins were quantified by computer-assisted image analysis. Mann-Whitney test was used to analyze the results establishing the level of significance of 5%. Results: Enemas with mesalazine in colonic segments without fecal stream decreased the inflammation score and increased the tissue content of all subtypes of mucins. The increase of tissue content of neutral, acid and sulfomucin was related to the time of intervention. Conclusion: Mesalazine enemas reduce the inflammatory process and preserve the content of mucins in colonic mucosa devoid of fecal stream.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Enemas with mesalazine increase the tissue contents of mucins in the colonic mucosa devoid of fecal stream

et al. 2019

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“…43,44 In contrast, WD with reduced fiber content disrupts the mucin layer exposing the intestinal epithelial cells to the luminal contents and this effect is attenuated by curcumin supplementation (unpublished observations). It is noteworthy that Junior et al reported curcumin mediated increase in the quantity of acid mucins in the intestine 45 and Xun et al showed that dietary addition of curcumin was more effective than quinocetone in improving intestinal mucosal barrier integrity, morphology, and immune status of weaned pigs. 46 Collectively, these data provide strong evidence for maintenance of the integrity of the mucus layer by curcumin.…”

Section: Layer 1 or The Intestinal Alkaline Phosphatase (Iap)mentioning

confidence: 99%

Curcumin-mediated regulation of intestinal barrier function: The mechanism underlying its beneficial effects

Ghosh

Wang

et al. 2018

Tissue Barriers

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Curcumin has anti-inflammatory, anti-oxidant and anti-proliferative properties established largely by in vitro studies. Accordingly, oral administration of curcumin beneficially modulates many diseases including diabetes, fatty-liver disease, atherosclerosis, arthritis, cancer and neurological disorders such as depression, Alzheimer's or Parkinson's disease. However, limited bioavailability and inability to detect curcumin in circulation or target tissues has hindered the validation of a causal role. We established curcumin-mediated decrease in the release of gut bacteria-derived lipopolysaccharide (LPS) into circulation by maintaining the integrity of the intestinal barrier function as the mechanism underlying the attenuation of metabolic diseases (diabetes, atherosclerosis, kidney disease) by curcumin supplementation precluding the need for curcumin absorption. In view of the causative role of circulating LPS and resulting chronic inflammation in the development of diseases listed above, this review summarizes the mechanism by which curcumin affects the several layers of the intestinal barrier and, despite negligible absorption, can beneficially modulate these diseases.

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Natural products in conditions associated with inflammatory bowel diseases: Colorectal cancer, diversion colitis, and obesity

Pereira¹,

Rizzato²,

Polezi³

et al. 2023

Natural Plant Products in Inflammatory Bowel Diseases

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Tissue sulfomucin and sialomucin content in colon mucosa without intestinal transit subjected to intervention with Curcuma longa (curcumin)

Abstract: Curcumin enemas increase the quantity of acid mucins in the intestinal flow in the excluded colon, with dose and time dependency.

Cited by 12 publications

References 26 publications

Enemas with mesalazine increase the tissue contents of mucins in the colonic mucosa devoid of fecal stream

Enemas with mesalazine increase the tissue contents of mucins in the colonic mucosa devoid of fecal stream

Curcumin-mediated regulation of intestinal barrier function: The mechanism underlying its beneficial effects

Natural products in conditions associated with inflammatory bowel diseases: Colorectal cancer, diversion colitis, and obesity

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