Can thıamıne pyrophosphate prevent desflurane ınduced hepatotoxıcıty ın rats?

Abstract

PURPOSE:To investigate the effects of thiamine pyrophosphate (TPP) against desflurane induced hepatotoxicity. METHODS:Thirty experimental animals were divided into groups as healthy (HG), desflurane control (DCG) , TPP and desflurane group (TDG). 20 mg/kg TPP was injected to intraperitoneally TDG. After one hour of TPP administration, desflurane was applied for two hours. After 24 hours, liver tissues of the animals killed with decapitation were removed. The oxidant/antioxidant levels and ALT, AST and LDH activities were measured. The histopathological examinations were performed in the liver tissues for all rats. RESULTS:Notwithstanding the levels of oxidants and liver enzymes were significantly increased (p<0.0001), antioxidant levels were significantly decreased in DCG (p<0.0001). On contrary to the antioxidant parameters were increased (p<0.05) the oxidant parameters and liver enzymes were decreased in TDG (p<0.0001). Whereas multiple prominent, congestion, hemorrhage and dilatation were observed in sinusoids and lymphocyte-rich inflammation results in the centrilobular and portal areas of liver tissue in DCG, these findings were observed less frequently in TDG. CONCLUSİON:Thiamine pyrophosphate prevented liver oxidative damage induced with desflurane and may be useful in prophylaxis of desflurane induced hepatotoxicity.

The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction

“…TPP has been demonstrated in earlier research to reduce oxidative stress caused by alcohol and paracetamol in animal liver and to have a hepatoprotective effect by shielding the liver tissue from oxidative damage (Tung et al 2005;Chin et al 2008). TPP treatment also considerably reduces desflurane-related histopathological damage by boosting antioxidant activity (Arslan et al 2016). We found no experimental trials examining the preventive effect of TPP against propofol-related hepatotoxicity in our assessment of the literature.…”

The effect of heat stress on hematological parameters and oxidative stress among bakery workers

“…The serum samples were held at −20°C until laboratory analysis. Oxidative stress biomarkers including MDA, NO, and TAC were measured in serum samples using Hangzhou Eastbiopharm Kits by double-antibody sandwich enzyme-linked immunosorbent assay (DRG, Germany) (Arslan et al, 2016; Boskabady and Mahtaj, 2015). Participants who had hematological parameters out of normal ranges (Rasouli et al, 2017) were classified as the abnormal group.…”

The negative effect of desflurane on reproductive capacity in female rats

“…When published literature is examined, it is seen that MDA and IL-1β increases in the experimental groups treated with desfl urane, while SOD and tGSH decreases (3,6,19,20). When the biochemical parameters were examined in this study, the increase in MDA and IL-1β in the DS-2 group was higher than in the DS-1 group.…”