Effect of sugarcane biopolymer in vocal fold of rabbits. Comparative study with calcium hydroxyapatite

Vasconcelos, Silvio José de; Leão, Rodrigo Augusto Souza; Bernardino-Araújo, Sidcley; Lira, Mariana Montenegro de Melo; Tsuji, Domingos Hiroshi

doi:10.1590/s0102-865020150030000004

Cited by 5 publications

(4 citation statements)

References 19 publications

(16 reference statements)

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“…In critical bone defects on calvaria of Wistar rats, SCB gel preparations associated with bone morphogenetic protein (BMP) showed to be a suitable scaffold for the BMP, presumably facilitating the controlled release of BMP during bone repair 11 . Although some studies proposed SCB as a promising material for grafting and other medical procedures, none of those researches aimed bone grafting with granulated SCB to this date [12][13][14][15][16][17] . Therefore, this paper focused on the effects of particulate (granule-shaped) SCB on bone repair relating it to its biocompatibility and bone neoformation.…”

Section: Introductionmentioning

confidence: 99%

The biopolymer sugarcane as filling material of critical defects in rats

Abreu

Lima²,

Souza

et al. 2016

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of particulate (granule-shaped) SCB on bone repair relating it to its biocompatibility and bone neoformation. METHODS:Thirty Wistar rats were submitted to a one 7-mm-diameter defect and divided equally into three experimental groups, with two different postoperative times of evaluation, 90 and 120 days. Each calvaria defect was filled up with clot (control group), particulated autogenous bone or granulated SCB. Five animals of each group were assessed at 90 and 120 days after surgery. In these two periods, histological and histometric analysis were obtained. RESULTS:The clot group showed a bone resorption trend while the autogenous bone group a bone repair trend. However in the SCB group, the critical defect filled up only with fibrous connective tissue and presented none bone neoformation. CONCLUSION:The sugarcane biopolymer when used in critical size defects was a biocompatible material and proved to be a good material to fill bone cavities, keeping them as uniform areas filled with soft tissue and avoiding the tissue shrinkage.

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Section: Introductionmentioning

confidence: 99%

The biopolymer sugarcane as filling material of critical defects in rats

Abreu

Lima²,

Souza

et al. 2016

Acta Cir. Bras.

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“…Histological results in rabbit laryngeal tissue showed severe giant cell aggregation (over 50% of slide area), light levels of lymphocytic inflammatory infiltrate, mild fibrosis, and mild angiogenesis at both 3 and 12 weeks after CaHA injection. Mucosal inflammation was mildly prevalent at 3 weeks but normalized at 12 weeks [ 23 ]. Similar results were obtained when CaHA was used as a facial filler.…”

Section: Discussionmentioning

confidence: 99%

Foreign body granuloma development after calcium hydroxylapatite injection for stress urinary incontinence: A literature review and case report

Csuka

Hanna

et al. 2022

Arab Journal of Urology

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Objectives To present a case of foreign body granuloma (FBG) development after injection of calcium hydroxylapatite as a urethral bulking agent and to review all documented cases of this phenomenon in the literature. Methods We analyzed a new case of calcium hydroxylapatite-induced FBG. We also conducted a literature review of the PubMed, Embase, CINAHL, and Web of Science databases through March 2022. Reports were included if they contained stress urinary incontinence patients that developed an FBG after calcium hydroxylapatite injection. The cases were reviewed for presenting symptoms, patient demographics, granuloma details, and surgical treatment. Results We screened 250 articles and included six articles between 2006 and 2015 in addition to the present case. The median age of the patients was 65.5 years (range 45–93), and all patients were female. The most common presenting symptoms and the proportion of patients affected were difficulty voiding (4/8), recurrent urinary incontinence (3/8), and dyspareunia (2/8). The median time between the first CaHA injection and discovery of the FBG was 5 months (range 1–50). The median longest dimension of the FBGs was 1.85 cm (range 1.0–3.0). The 8 masses observed were evenly distributed throughout the urethra, with 3 in the bladder neck, 2 in the midurethra, and 3 in the distal urethra. Surgical excision was the predominant management choice, with some variation in technique. Conclusions Severe, persistent lower urinary tract symptoms after calcium hydroxylapatite injection may indicate an FBG, which has been successfully managed with surgical excision.

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“…For this reason, hydroxyapatite has been introduced for vocal cord injection and is increasingly used 25 . Although its better durability and volume stability, often for a few years, is favorable for persistent vocal fold paralysis with a glottic gap, several adverse reports of foreign body reactions and granuloma formation, 26,27 and even implant migration together with dislocation of the material 28 and an unfavorable biomechanical aspect attributable to the stiffness of the material regarding phonation 29 have appeared in the literature. One material that was thought to combine favorable biomaterial and biomechanical characteristics and endurance properties was autologous fat.…”

Section: Discussionmentioning

confidence: 99%

Fibrin Gel Suspended Autologous Chondrocytes as Cell‐based Material for long‐term Injection Laryngoplasty

et al. 2020

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Objectives/Hypothesis Injection laryngoplasty of materials for unilateral vocal‐fold paralysis has shown various results regarding the long‐term stability of the injected material. We evaluated a fibrin‐gel based cell suspension with autologous chondrocytes in‐vitro and in‐vivo as long‐term‐stable vocal‐fold augmentation material in an animal model. Study Design This study compises an in vitro cell‐culture part as well as an in vivo animal study with New Zealand White Rabbits. Methods In in‐vitro experiments, auricular chondrocytes harvested from 24 New Zealand White Rabbits cadavers were cultivated in pellet cultures to evaluate cartilage formation for 4 weeks using long‐term‐stable fibrin gel as carrier. Injectability and injection volume for the laryngoplasty was determined in‐vitro using harvested cadaveric larynxes. In‐vivo 24 Rabbits were biopsied for elastic cartilage of the ear and autologous P1 cells were injected lateral of one vocal cord into the paraglottic space suspended in a long‐term‐stable fibrin gel. Histologic evaluation was performed after 2, 4, 12, and 24 weeks. Results During 12‐week pellet culture, we found extracellular matrix formation and weight‐stable cartilage of mature appearance. In‐vivo, mature cartilage was found in two larynxes (n = 6) at 4 weeks, in four (n = 6) at 12 weeks, and in five (n = 6) at 24 weeks mostly located in the paraglottic space and sometimes with spurs into the vocalis muscle. Surrounding tissue was often infiltrated with inflammatory cells. Material tended to dislocate through the cricothyroid space into the extraglottic surrounding tissue. Conclusions A cell‐based approach with chondrocytes for permanent vocal‐fold augmentation has not previously been reported. We have achieved the formation of structurally mature cartilage in the paraglottic space, but this is accompanied by difficulties with dislocated material, deformation of the augmentation, and inflammation. Level of Evidence N/A Laryngoscope, 131:E1624–E1632, 2021

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Effect of sugarcane biopolymer in vocal fold of rabbits. Comparative study with calcium hydroxyapatite

Cited by 5 publications

References 19 publications

The biopolymer sugarcane as filling material of critical defects in rats

The biopolymer sugarcane as filling material of critical defects in rats

Foreign body granuloma development after calcium hydroxylapatite injection for stress urinary incontinence: A literature review and case report

Fibrin Gel Suspended Autologous Chondrocytes as Cell‐based Material for long‐term Injection Laryngoplasty

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