Effect of propranolol on capsular reaction around silicone implants in guinea pigs

Mesquita, Charles Jean Gomes de; Guimarães, Sérgio Botelho; Filho, José Alberto Dias Leite; Maciel, Felipe Silva; Rocha, José Lima de Carvalho; Leite, José Alberto Dias

doi:10.1590/s0102-86502015001000004

Cited by 3 publications

(2 citation statements)

References 38 publications

(91 reference statements)

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“…Flos Datura has been extensively used in TCM for centuries. It has been reported that clinical use of Flos Datura showed a signi cant effect on the treatment of psoriasis [26][27]. Psoriasis is one of the most common immune-mediated chronic in ammatory skin diseases.…”

Section: Discussionmentioning

confidence: 99%

Anti-Psoriasis Inflammation And Anti-Oxidation of The Extract From The Flower of Datura Metel L.

Wang¹,

Zhang²,

Wang³

et al. 2021

Preprint

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Background： At present, Flos Datura L. has been reported to have obvious anti-psoriasis effect, but its active ingredient is still unknown. Objectives: The chemical characteristics and anti-psoriasis inflammatory and antioxidant activities of partially purified flavonoids components of Flos Daturae (FC-FD) were investigated.Methods: FC-FD were analyzed by ultra-performance liquid chromatography (UPLC)-electrospray ionization (ESI)-quadrupole time-of-flight (Q-TOF)-mass spectrometry (MSE) combined, while antioxidant potency was monitored using a drosophila model. And the immune inflammatory response was measured in guinea pig animal model.Results: After comparison, 14 products were identified. In vitro antioxidant activity assays showed that FC-FD could effectively scavenge hydroxyl radicals. Furthermore, the longest survival time of the male and female Drosophila melanogaster was extended by 100.50% and 96.82%, respectively. In addition, in the psoriasiform guinea pigs model, FC-FD could decrease the histopathological score and the expression of PCNA protein, and block the production of TNF-α. Notably, the partial purified ﬂavonoids extracted from Flos Datura was and identiﬁed for the ﬁrst time. Conclusions: The results indicated that FC-FD are potential natural antioxidants in extending lifespan and anti-psoriatic inflammatory drugs.

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Section: Discussionmentioning

confidence: 99%

Anti-Psoriasis Inflammation And Anti-Oxidation of The Extract From The Flower of Datura Metel L.

Wang¹,

Zhang²,

Wang³

et al. 2021

Preprint

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“…Histologically, fibrous tissue is characterized by excessive production and deposition of extracellular matrix components such as fibronectin and collagen, and its formation is triggered by inflammation [31][32][33]. Hence, we next investigated the transcript levels of genes related to fibrosis and inflammation.…”

Section: Asc Treatment Altered the Levels Of Fibrogenic Genes And Rel...mentioning

confidence: 99%

Implantation and tracing of green fluorescent protein-expressing adipose-derived stem cells in peri-implant capsular fibrosis

Park

Kwon

et al. 2023

Stem Cell Res Ther

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Background Adipose-derived stem cells (ASCs) have been reported to reduce fibrosis in various tissues. In this study, we investigated the inhibitory role of ASCs on capsule formation by analyzing the histologic, cellular, and molecular changes in a mouse model of peri-implant fibrosis. We also investigated the fate and distribution of ASCs in the peri-implant capsule. Methods To establish a peri-implant fibrosis model, customized silicone implants were inserted into the dorsal site of C57BL/6 wild-type mice. ASCs were harvested from the fat tissues of transgenic mice that express a green fluorescent protein (GFP-ASCs) and then injected into the peri-implant space of recipient mice. The peri-implant tissues were harvested from postoperative week 2 to 8. We measured the capsule thickness, distribution, and differentiation of GFP-ASCs, as well as the cellular and molecular changes in capsular tissue following ASC treatment. Results Injected GFP-ASCs were distributed within the peri-implant capsule and proliferated. Administration of ASCs reduced the capsule thickness, decreased the number of myofibroblasts and macrophages in the capsule, and decreased the mRNA level of fibrogenic genes within the peri-implant tissue. Angiogenesis was enhanced due to trans-differentiation of ASCs into vascular endothelial cells, and tissue hypoxia was relieved upon ASC treatment. Conclusions We uncovered that implanted ASCs inhibit capsule formation around the implant by characterizing a series of biological alterations upon ASC treatment and the fate of injected ASCs. These findings highlight the value of ASCs for future clinical applications in the prevention of capsular contracture after implant-based reconstruction surgery.

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Histological and immunohistochemical characteristics of capsular synovial metaplasias that form around silicone breast implants

et al. 2018

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Effect of propranolol on capsular reaction around silicone implants in guinea pigs

Cited by 3 publications

References 38 publications

Anti-Psoriasis Inflammation And Anti-Oxidation of The Extract From The Flower of Datura Metel L.

Anti-Psoriasis Inflammation And Anti-Oxidation of The Extract From The Flower of Datura Metel L.

Implantation and tracing of green fluorescent protein-expressing adipose-derived stem cells in peri-implant capsular fibrosis

Histological and immunohistochemical characteristics of capsular synovial metaplasias that form around silicone breast implants

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