Nutraceutical preconditioning with arginine and oil mixes. Effects on inflammatory mediators, oxidative stress and lipid profile in patients undergoing radical prostatectomy

Abstract

PURPOSE:To investigate whether there is any effect resulting from preconditioning with nutraceutical supplementation containing arginine and oil mixes with high ω9:ω6 ratio and low ω6:ω3 ratio containing EPA and DHA, ALA fatty acids on inflammatory mediators, antioxidant and lipid profile modulation in surgical trauma. METHODS:Twenty-six men scheduled for radical prostatectomy were randomized into three groups and treated as follows: Group 1 (skim milk, 0% fat), Group 2 (supplement with ω6:ω3 ratio of 8:1 and arginine) and Group 3 (supplement with high ω9:ω6 ratio of 3.2:1 and low ω6:ω3 ratio of 1.4:1 and arginine). Patients received skin milk or supplements twice a day (200 ml) during five days prior to surgery. Peripheral venous blood samples were collected at three different timepoints: five days before surgery (PRE), before anesthesia induction (IND) and on the 2 nd postoperative day (POS). Parameters analyzed included inflammatory cytokines (IL-1β, IL-6, IL-8 and TNF-α), antioxidants (catalase), lipid profile and heat shock protein (HSP-27). RESULTS:There were no significant differences between groups on inflammatory mediators and antioxidant parameters. However, lipid profile values (Cholesterol, LDL, Triglycerides, VLDL), were significantly different. CONCLUSION:Preconditioning with arginine and oil mixes containing high ω9:ω6 ratio and low ω6:ω3 ratio, has no effects on inflammatory mediators and oxidative stress in patients undergoing radical prostatectomy. Reduction of cholesterol, triglycerides, LDL and VLDL profiles may be related to the trauma effect.

Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer

“…Surgical trauma causes stress responses such as inflammatory response and oxidative stress [ 5 ]. Oxidative stress occurs when the generation of reactive oxygen species (ROS) and antioxidants in the body is out of balance [ 6 ].…”

“…Pappas-Gogos et al reported that laparoscopic colorectal surgery was associated with lower oxidative stress than open surgery by examining oxidative stress markers including 8-hydroxyguanosine, 8-isoprostanes, protein carbonyl, and 3-nitrotyrosine [ 7 ]. Surgery can produce proinflammatory cytokines and severe immune system changes, leading to an increased incidence of postoperative sepsis and inflammatory complications [ 5 ]. A previous study indicated that rectal surgery caused the release of pro- and anti-inflammatory cytokines, and there was a lower inflammatory response during the laparoscopic surgery than open surgery [ 8 ].…”