The neuroprotective effect of Sulindac after ischemia-reperfusion injury in rats

Abstract

PURPOSE:To investigate the neuroprotective effects of Sulindac on the hippocampal complex after global cerebral ischemia/reperfusion (I/R) injury in rats. METHODS:Thirty one Sprague-Dawley rats were used, distributed into group I (sham) n:7 were used as control. For group II (n:8), III (n:8) and IV (n:8) rats, cerebral ischemia was performed via the occlusion of bilateral internal carotid artery for 45 minutes and continued with reperfusion process. 0.3 mL/kg/h 0.9 % sodium chloride was infused intraperitoneally to the Group II rats before ischemia, 5µg/kg/h/0.3 ml sulindac was infused intraperitoneally to the Group III rats before ischemia and 5µg/kg/h/0.3 ml sulindac was infused intraperitoneally to the Group IV rats after ischemia and before reperfusion process. The levels of MDA, GSH and MPO activity were measured in the left hippocampus tissue. The hippocampal tissue of all group members were taken for histopathological study.

<p>Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation</p>

“…37 Therefore, these activity species were decreased by SS. 37,38 Previous studies investigated that the radical scavengers can be used to protect DNA from free radicals that were generated by radiation. 39 In the normal cells, exposure to IR initiates released inflammatory cytokines, which resulted in DNA damage.…”