Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats

Holanda, Cecília Maria de Carvalho Xavier; Barbosa, Delianne Azevedo; Demeda, Vanessa Fávero; Bandeira, Flora Tamires Moura; Medeiros, Hilkéa Carla Souza de; Pereira, Kércia Regina Santos Gomes; Barbosa, Vanessa Santos de Arruda; Medeiros, Aldo Cunha

doi:10.1590/s0102-86502014000300001

Cited by 16 publications

(19 citation statements)

References 18 publications

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“…However, such danger can be averted if the extract is used over a short period of time, as the effect is observed to be time and concentration dependent. The research find is in line with the finding of (Arthur et al, 2011;Holanda et al, 2014) in which both expresses insignificant effect on the liver function parameters and the later even reported histo-protective potential of the plant extract. However the variations noted with the current work are, both authors worked on aqueous extract.…”

Section: Table 5 Effect Of Annona Muricata (L) Methanol Extract On Sosupporting

confidence: 90%

Acute and sub- chronic toxicity profile of <i>Annona muricata</i> (Sour sop) on wister albino rats

Sherif¹,

Gabi²,

Abdullahi³

2018

Bayero J. Pure App. Sci.

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In drug development, determination of its toxic profile is paramount and usually the initial step in its evaluation. Phytochemical constituent's assessment can subsequently be muricata is an evergreen shrub that is endowed with ethno source of food. The significant needs to evaluate the toxic profile of the plant lead to the design of this work. Therefore this work is desi as the index) and sub-chronic toxicity profile of the leaf extracts. serum levels of some biochemical parameters which include alkaline phosphatase (ALP), alanin aminotransferase (ALT) and aspartate aminotransferase (AST). Also include the effect on the kidney function parameters such as Urea, creatinine and electrolyte (K+, Na+, Cl LD 50 of the extract indicated that the plant extract is relatively safe with no mortality recorded at dose >5000mg/kg body weight of the drug. There was no significant (P difference in the serum level of ALP ALT and AST for the liver functi significant variation recorded on the kidney function parameters. However, salient mild effect on the liver and kidney was observed from the histopathological examination, but can be effectively averted if extended use of higher concentration of the extract is avoided, as the effect is observed to be both concentration and time dependent. suggested, the possible hepato-protective and neuphro extract which should be further investigated

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Section: Table 5 Effect Of Annona Muricata (L) Methanol Extract On Sosupporting

confidence: 90%

Acute and sub- chronic toxicity profile of <i>Annona muricata</i> (Sour sop) on wister albino rats

Sherif¹,

Gabi²,

Abdullahi³

2018

Bayero J. Pure App. Sci.

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“…In this study, fructose was also not able to change this biodistribution. This result is consistent with the results obtained by Holanda et al (2014), who investigated the biodistribution of 99m Tcsodium phytate in the liver, spleen and blood of rats fed food rich in fructose (soursop) and observed no change in their uptake.…”

Section: Discussionsupporting

confidence: 93%

“…The authors attribute this result, possibly inhibition of carnitine palmitoyltransferase I enzyme (CPTI) involved in the beta oxidation, which leads to an accumulation of fatty acids in the liver and induces liver damage (Song et al, 2012). In a study by Holanda et al (2014), it was observed that the use of Annona muricata extract (soursop) (25 mg/kg/day), which is a rich source of fructose, did not significantly alter the levels of AST and ALT. The changes in hepatic enzymes (AST and ALT) caused by consumption of fructose in studies by Song et al (2012) were due to different concentrations of the A. muricata extract and high dose used by the authors (50 mg/kg/day).…”

Section: Discussionmentioning

confidence: 99%

“…There are many factors, both external and internal to the body, that may affect the normal biodistribution of radiopharmaceuticals, such as surgical procedures, pathophysiological mechanisms, radiation, infections, smoking (tobacco), use of natural or synthetic drugs and some foods, and nutritional conditions (Barbosa et al, 2009;Bernardo-Filho et al, 2005;Cekic et al, 2011;Holanda et al, 2014;Passos et al, 2002;Valença et al, 2005;Vallabhajosula et al, 2010). Rocha et al (2011), demonstrated that sucralose in different concentrations can change biodistribution of radiopharmaceuticals as sodium pertechnetate in kidney and 99m Tc-DTPA in various organs such as pancreas, stomach, spleen, muscle, and thyroid.…”

Section: Introductionmentioning

confidence: 99%

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Influence of sweeteners in the biodistribution of radiopharmaceutical and laboratory tests in rats

Queiroz¹,

Barbosa²,

Holanda³

et al. 2016

Afr. J. Biotechnol.

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This study aimed to evaluate the effect of supplementation of sucralose and fructose on the metabolism of adolescent rats. Eighteen male Wistar rats were divided into 3 groups: control group (GC), fructose group (GF) treated with 50 mg/kg of fructose, and sucralose group (GS) receiving 50 mg/kg of sucralose for 24 days. The weight and feed intake were measured weekly. At the end of the experiment, some biochemical parameters, histopathology of the liver and biodistribution of the radiotracer 99m Tc-sodium phytate in liver and blood were analyzed. The GF showed higher body weight only in the first week compared with GS and GC (p<0.05). Histopathology and % ATI/g radiotracer 99m Tc-sodium phytate in liver and blood were not different between the groups. The GF showed higher values of aspartate aminotransferase activity, bilirubin, alkaline phosphatase activity and gamma glutamyl transferase activity, compared with the other groups (GC and GS) (p<0.05). Activity of alanine aminotransferase and albumin level of GF were higher than GS (p<0.05). For other parameters, no statistical difference was observed. It was concluded that the use of fructose during the experiment was able to alter hepatic enzymes, but on the other hands, the use of sucralose caused no change.

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“…However, despite their benefits, hepatotoxic effects have been reported with the use of herbal medicines in rats, probably due to the alcohol in their composition 30 . Therefore, in this study, the effects of administering mastruz extract in rats with induced OP were evaluated by means of histological and biochemical analyses.…”

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confidence: 99%

Chenopodium ambrosioides L. extract prevents bone loss

Soares

Carvalho

et al. 2015

Acta Cir. Bras.

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PURPOSE:To evaluate the effect of the Chenopodium ambrosioides L (mastruz) extract for preventing bone loss and bone metabolism in ovariectomized rats. METHODS:Twelve rats were subjected to bilateral ovariectomy for inducing osteoporosis. After surgery, they were divided into two groups: Ovariectomy-control group (G1, n=6), receiving 0.5 ml distilled water by gavage for 30 days, and Ovariectomy plus mastruz group (G2, n=6), receiving 0.5 ml of the hydroalcoholic extract of mastruz at 10% concentration (50mg) daily, for the same period.Then, the blood of the animals was collected for further biochemical analysis (liver function) and tibia and liver were removed for histological and histomorphometric analyses. RESULTS:The cortical bone was significantly larger in the G2 than G1, whereas G1 presented the highest amount of adipocytes in the bone marrow (p<0.05). The blood levels of aspartate aminotransferase, triglycerides and cholesterol were significantly higher, whereas globulin and lactate dehydrogenase were smaller in G2 than G1. CONCLUSION:The hydroalcoholic extract of mastruz has effects on bone metabolism by changing blood proteins and enzymes and preventing both bone loss and the substitution of bone marrow cells by

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Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats

Abstract: The A. muricata hydroalcoholic extract negatively influenced the uptake of 99mTc-DMSA in bladder, kidney and blood of rats.

Cited by 16 publications

References 18 publications

Acute and sub- chronic toxicity profile of <i>Annona muricata</i> (Sour sop) on wister albino rats

Acute and sub- chronic toxicity profile of <i>Annona muricata</i> (Sour sop) on wister albino rats

Influence of sweeteners in the biodistribution of radiopharmaceutical and laboratory tests in rats

Chenopodium ambrosioides L. extract prevents bone loss

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