Rapid prototyping of three-dimensional biomodels as an adjuvant in the surgical planning for intracranial aneurysms

Erbano, Bruna Olandoski; Opolski, Ana Cristina; Olandoski, Márcia; Foggiatto, José Aguiomar; Kubrusly, Luiz Fernando; Dietz, Ulrich; ZINI, Cassio; Marinho, Melissa Mitsue Makita Arantes; Leal, André Giacomelli; Ramina, Ricardo

doi:10.1590/s0102-86502013001100002

Cited by 43 publications

(25 citation statements)

References 16 publications

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“…Several additive manufacturing references for aneurysm models have previously been reported 17 18 21 26 27. In contrast with the technique described here, these models used professional grade SLA printers.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional printing of anatomically accurate, patient specific intracranial aneurysm models

Anderson

Thompson

Alkattan

et al. 2015

J NeuroIntervent Surg

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ObjectiveTo develop and validate a method for creating realistic, patient specific replicas of cerebral aneurysms by means of fused deposition modeling.MethodsThe luminal boundaries of 10 cerebral aneurysms, together with adjacent proximal and distal sections of the parent artery, were segmented based on DSA images, and corresponding virtual three-dimensional (3D) surface reconstructions were created. From these, polylactic acid and MakerBot Flexible Filament replicas of each aneurysm were created by means of fused deposition modeling. The accuracy of the replicas was assessed by quantifying statistical significance in the variations of their inner dimensions relative to 3D DSA images. Feasibility for using these replicas as flow phantoms in combination with phase contrast MRI was demonstrated.Results3D printed aneurysm models were created for all 10 subjects. Good agreement was seen between the models and the source anatomy. Aneurysm diameter measurements of the printed models and source images correlated well (r=0.999; p<0.001), with no statistically significant group difference (p=0.4) or observed bias. The SDs of the measurements were 0.5 mm and 0.2 mm for source images and 3D models, respectively. 3D printed models could be imaged with flow via MRI.ConclusionsThe 3D printed aneurysm models presented were accurate and were able to be produced inhouse. These models can be used for previously cited applications, but their anatomical accuracy also enables their use as MRI flow phantoms for comparison with ongoing studies of computational fluid dynamics. Proof of principle imaging experiments confirm MRI flow phantom utility.

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Section: Discussionmentioning

confidence: 99%

Three-dimensional printing of anatomically accurate, patient specific intracranial aneurysm models

Anderson

Thompson

Alkattan

et al. 2015

J NeuroIntervent Surg

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“…Sensory haptic feedback is also different from the real clipping [9][10][11]. 3D printing technology has important application value in the diagnosis and treatment of aneurysm especially in preoperative surgical rehearsal and neurosurgical training [12][13][14][15]. We think its advantages can be reflected in the following aspects:…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional printing technology for treatment of intracranial aneurysm

Yin

et al. 2016

Chin Neurosurg Jl

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Background: The development of three-dimensional (3D) printing technology provides a new method for surgical treatment, but currently there are few reports on its application in the treatment of aneurysm. The aim of the present study was to explore the materials and methods of fabricating 3D printed individual aneurysm model and its value in the treatment of intracranial aneurysm. Methods: Twenty-four patients with intracranial aneurysm diagnosed by CTA who had undergone operation in our hospital were analyzed retrospectively. CTA Data collected at the time of surgery was used for reconstruction. Soft Mimics 17.0 was used to reconstruct the thin layer CTA scan data into 3D image and the final data was sent to the 3D printer for fabricating the model. We compared the proposed 3D printed model-based preoperative plan and the actual approach used in the surgery based on CTA data to evaluate the value of the 3D printed model in preoperative planning, and picked out the materials which were more suitable for the clinic. Results: Twenty-four aneurysm models with high degree of reality were fabricated successfully with 3D-printing technology. The patients' blood vessels, skulls and aneurysms were printed into the reality model at a ratio of 1:1. It is reported that the soft material-based, 3D printed vascular and aneurysm model more closely resembled the characteristics of the real blood vessels, thus provides a better simulation compared to the plaster-based model. Compared with the original operation plan, 3D printed model could be used for pre-operative aneurysm clip selection, and provide more intuitive information in selection of operational approach. Conclusions: 3D printed model can be used as an operational physical model to design operative schemes, choose the best operative paths and select suitable aneurysm clips by its high simulation degree and individualized characteristics. The model is helpful for surgical planning, especially for the preoperative plan of treating refractory multiple aneurysms and giant aneurysms.

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“…However the material formulations used in MJM printers are proprietary and expensive, and rigorous biocompatibility and biofunctionality studies are absent so far. MJM technology has been widely used in the medical sector to create anatomically accurate models for orthopedic 41 , cardiac 42 and intracranial 43 surgeries. Both MJM and Binder Jet methods can build structures that are comparatively large (8-inch cube), and have been used to build prototypes with smooth finishes and complex shapes, including manufacturing tools, working gears and metallic electrodes 44 .…”

Section: 3d-printed Microfluidic Systems Come In Different Flavorsmentioning

confidence: 99%

The upcoming 3D-printing revolution in microfluidics

et al. 2016

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In the last two decades, the vast majority of microfluidic systems have been built in poly(dimethylsiloxane) (PDMS) by soft lithography, a technique based on PDMS micromolding. A long list of key PDMS properties have contributed to the success of soft lithography: PDMS is biocompatible, elastomeric, transparent, gas-permeable, water-impermeable, fairly inexpensive, copyright-free, and rapidly prototyped with high precision using simple procedures. However, the fabrication process typically involves substantial human labor, which tends to make PDMS devices difficult to disseminate outside of research labs, and the layered molding limits the 3D complexity of the devices that can be produced. 3D-printing has recently attracted attention as a way to fabricate microfluidic systems due to its automated, assembly-free 3D fabrication, rapidly decreasing costs, and fast-improving resolution and throughput. Resins with properties approaching those of PDMS are being developed. Here we review past and recent efforts in 3D-printing of microfluidic systems. We compare the salient features of PDMS molding with those of 3D-printing and we give an overview of the critical barriers that have prevented the adoption of 3D-printing by microfluidic developers, namely resolution, throughput, and resin biocompatibility. We also evaluate the various forces that are persuading researchers to abandon PDMS molding in favor of 3D-printing in growing numbers.

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Rapid prototyping of three-dimensional biomodels as an adjuvant in the surgical planning for intracranial aneurysms

Cited by 43 publications

References 16 publications

Three-dimensional printing of anatomically accurate, patient specific intracranial aneurysm models

Three-dimensional printing of anatomically accurate, patient specific intracranial aneurysm models

Three-dimensional printing technology for treatment of intracranial aneurysm

The upcoming 3D-printing revolution in microfluidics

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