Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice

Abstract

PURPOSE:To investigate the hemopreventive effect of defatted flaxseed meal in C57BL/6 mice after induction of precancerous colon lesions with 1.2-dimethylhydrazine (DMH). METHODS: Thirty-six 12-week-old C57BL/6 mice were divided into three treatment groups(n=12 in each group): (1) diet with 10% defatted flaxseed meal; (2) diet with defatted flaxseed meal and precancerous colon lesions induced by DMH; and (3) precancerous colon lesions induced by DMH, without defatted flaxseed meal. The incidence of aberrant crypt foci (ACF), oxidative processes, expression of tumor suppressor proteins and cyclins, as well as the profile of short-chain fatty acids (SCFA) in animal feces were investigated in the presence and absence of DMH. RESULTS:The rats consuming defatted flaxseed meals showed lesions with lower multiplicity and a reduced incidence of lesions. No changes in the expression of tumor suppressor proteins and those involved in cell cycle control were detected. CONCLUSION: Defatted flaxseed meal protected the distal colon of mice from precancerous lesions.

Chemoprevention of Colorectal Cancer by Dietary Compounds

“…Moreover, deflated flaxseeds reduced the incidence of precancerous lesions in the proximal, distal and middle colon. The exact mechanism of action is not known, since no changes are observed in tumor protein p53 (p53), cyclin-dependent kinase inhibitor 1 (p21 CIP1/WAF1 ) and multiple tumor suppressor 1 (p16) expression and the authors did not notice an increase in fecal short chain fatty acids [170]. Sesamol , a lignin from sesame seeds, significantly reduced the number of intestinal polyps in mice with colorectal cancer, through suppression of COX-2 and prostaglandin E2 receptor expression levels [171].…”

Defatted flaxseed meal incorporated corn-rice flour blend based extruded product by response surface methodology

“…All these compounds possess human health benefits (Hall et al 2006). Moreover, DFM was reported to have protective ability for distal colon of mice from precancerous lesions (Gomides et al 2013). DFM exhibited broad spectrum of bioactivities along with hypo-cholesterolemic and anti-atherosclerotic effect (Kasote et al 2011;Prasad 2005).…”

Linhaça e azeite de oliva extra-virgem: composição nutricional e efeitos na colite ulcerativa

“…Gomides et al [18] também acharam resultados positivos a nível de cólon no uso da linhaça. Os autores objetivaram provar a capacidade da dieta adicionada de linhaça desengordurada a 10% por 15 semanas de prevenir a ocorrência de lesões pré-cancerígenas em camundongos C57BL/6; apesar dos autores não encontrarem melhoras em proteínas supressoras do tumor e outras envolvidas, a dieta com esse tipo de linhaça proporcionou proteção da mucosa de cólon distal, através da observação de baixa multiplicidade e reduzida incidência de lesões [18].…”

“…Estudos recentes parecem relacionar o consumo de linhaça e AOEV com a prevenção e o tratamento da colite ulcerativa (CU) [12][13][14][15], uma doença inflamatória intestinal (DII) caracterizada por inflamação contínua principalmente localizada no reto [16]. Tais alimentos poderiam ser responsáveis pela melhora dos danos a nível de mucosa em intestino grosso afetada, bem como pela atenuação de processo inflamatório local, através da redução de enzimas e proteínas pró-inflamatórias, como ciclo-oxigenase-2 (COX-2), óxido nítrico sintase (iNOS), fator de necrose tumoral α (TNF-α), interferon-γ (IFN-γ), Interleucina-1β (IL-1β) e interleucina-6 (IL-6) [12][13][14][15]17,18].…”