Effects of angico extract (Anadenanthera colubrina var. cebil) in cutaneous wound healing in rats

Pessoa, Wagner Soares; Estevão, Lígia Reis de Moura; Simões, Ricardo Santos; Barros, Maria Edna Gomes de; Mendonça, Fábio de Souza; Baratella-Evêncio, Liriane; Evêncio-Neto, Joaquim

doi:10.1590/s0102-86502012001000001

Cited by 39 publications

(29 citation statements)

References 15 publications

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“…As atividades encontradas neste trabalho, podem ser conferidas a metabólitos secundários já detectados no angico como taninos (MONTEIRO et al, 2006), saponinas, triterpenos, açúcares redutores, antocianidinas e flavonoides (PESSOA et al, 2012). Como por exemplo a Anadantosídeo, flavonóide isolado das cascas de angico (Piacente et al, 1999).…”

Section: Resultsunclassified

PRODUÇÃO E AVALIAÇÃO DE ATIVIDADE BIOLÓGICA DE POMADA A BASE DE EXTRATO DE Anadenanthera colubrina (Vell.) Brenan

Rocha¹,

Sila²,

Padilha³

et al. 2018

Blucher Biophysics Proceedings

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Section: Resultsunclassified

PRODUÇÃO E AVALIAÇÃO DE ATIVIDADE BIOLÓGICA DE POMADA A BASE DE EXTRATO DE Anadenanthera colubrina (Vell.) Brenan

Rocha¹,

Sila²,

Padilha³

et al. 2018

Blucher Biophysics Proceedings

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“…The animals were housed in individual cages with commercial chow (Presence (r) , Purina) and maintained at 23-25ºC, under a 12 hours light/dark cycle, at the Pharmacy Department, UFPE, with water ad libitum, After one week of adaptation, the animals were anesthetized with a combination of 2% xylazine hydrochloride (3mg/kg) and 10% ketamine hydrochloride (10mg/kg), administered intramuscularly 13 . The dorsal fur of the animals was trichotomized in the thoracic region and antisepsis was performed…”

Section: ■ Methodsmentioning

confidence: 99%

Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L

et al. 2017

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Purpose: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with wild plum (Ximenia americana) essential oil-based ointment in rats. Methods: Sixty rats were submitted to two cutaneous wounds in the thoracic region, on the right and left antimeres. Thereon, they were divided into three groups: GX (wounds treated once a day with hydro alcoholic branch extract of Ximenia amerIcana), GP (wounds that received vehicle), and GC (wounds without product ap-plication). Wounds were measured immediately after the injury as well as 4, 7, 14 and 21 days post-topical application of the extract. At these days, five rats from each group were euthanatized. Thereafter, samples were fixed in 10% formalde-hyde and processed for paraffin embedding. Sections were stained with H.E, Masson's Trichrome and toluidine blue for morphological, morphometrical and histopathological analysis, under light microscopy. The degree of epithelial con-traction was measured and mast cell concentrations were also evaluated with an image analyzer (Image Pro-plus®software). Results: The extract treated group showed lower mast cell concentrations in the 4th day of lesion, as compared to GP (GX GP = GC; p<0.05). Conclusion: Ointment containing 10% X. americana induces a decrease in mast cell concen-tration, at the beginning of the healing process, and promotes early skin wound contraction in rats.

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“…However, there are few scientific data of the reported properties of this medicinal plant by the folk medicine 6 . Lima et al 7 and Pessoa et al 8 studied the healing activity of alcoholic extract of angico (Anadenanthera colubrina (Vell) Brenan) and noted accelerated healing properties in injured tissue, suggesting that this plant present potential medicial properties.…”

Section: Anadenanthera Colubrina (Fabaceae-mentioning

confidence: 99%

“…The extract was prepared from the bark of a tree at the Pharmacy Department of the Pharmacognosy Laboratory, UFPE according to the methodology described by Pessoa et al 8 . An aliquot equivalent to 5g of this extract was diluted in 70% ethanol to yield the hydroalcoholic extract at 5% and was kept in an amber glass container at room temperature until the experiment.…”

Section: Preparation Of the Extract Of Anadenanthera Colubrina Var Cmentioning

confidence: 99%

Fibrogenesis and epithelial coating of skin wounds in rats treated with angico extract (Anadenanthera colubrina var. cebil)

et al. 2015

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PURPOSE:To evaluate the effects of angico bark extract (Anadenanthera colubrina var. cebil) in the healing process of the skin of rats. METHODS:Twenty adult male rats were divided into four groups of five animals each, according to the respective postoperative days, as follow: G4, G7, G14 and G21. Each group received two incisions on skin and subcutaneous tissue in the right and left antimere of the thoracic region, separated by a distance of 2 cm. The right lesion was treated daily with saline and the left with the angico alcoholic extract (5%). At the end of each experimental period, the animals were euthanized and fragments of the wound area with the edges were removed, fixed in 10% formaldehyde solution and processed for paraffin embedding. Histological sections (5 µm of thickness) were stained with hematoxylin and eosin (HE), Gomori trichromic and picrosisirus red for morphological and morphometric analyses.Statistical analysis was done by ANOVA and Tukey-Kramer test (p<0.05). RESULTS:Morphological analysis showed larger fibroblasts and a higher concentration of collagen fibers in skyn wounds treated with the angico extract. Morphometric analysis demonstrated a significant increase in the number of fibroblasts at 7th and collagen in 7th and 14th days (p<0.01) in wounds treated with the angico extract. CONCLUSION:The angico alcoholic extract (Anadenanthera colubrina var. cebil) induces the acceleration of wound healing in skin wounds of rats.

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Effects of angico extract (Anadenanthera colubrina var. cebil) in cutaneous wound healing in rats

Abstract: The angico alcoholic extract (Anadenanthera colubrina var. cebil) induces the acceleration of wound healing in skin wounds of rats.

Cited by 39 publications

References 15 publications

PRODUÇÃO E AVALIAÇÃO DE ATIVIDADE BIOLÓGICA DE POMADA A BASE DE EXTRATO DE Anadenanthera colubrina (Vell.) Brenan

PRODUÇÃO E AVALIAÇÃO DE ATIVIDADE BIOLÓGICA DE POMADA A BASE DE EXTRATO DE Anadenanthera colubrina (Vell.) Brenan

Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L

Fibrogenesis and epithelial coating of skin wounds in rats treated with angico extract (Anadenanthera colubrina var. cebil)

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