Molars extraction for bone graft study in rabbits

Manso, José Eduardo Ferreira; Mourão, Carlos Fernando de Almeida Barros; Pinheiro, Flávio Alexandre Lima; Ferreira, Manoel Luiz; Silva, Paulo César; Schanaider, Alberto

doi:10.1590/s0102-86502011000800012

Cited by 7 publications

(6 citation statements)

References 16 publications

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“…For a more realistic surgical applicability, the in-vivo model must include the tooth alveolus as an anatomical cavity. Indeed, as previously demonstrated by the authors 6 , the rabbit implant socket is a feasible and successful in vivo model for the investigation of bone remodeling on fresh extraction sockets in smaller animals.…”

Section: Discussionmentioning

confidence: 66%

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In-vivo bone response to titanium screw implants anodized in sodium sulfate

Pinheiro

Mourão

Diniz³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the early bone response to a nanotextured dental implant treated with sodium sulfate (Na 2 SO 4 ), using a rabbit model. METHODS:Twelve animals were randomly divided into group 1 (Control) -machined implants and group 2 (Test) -nanotextured implants. Extra-oral incision was performed to provide access to intended surgical site where the dental implant was inserted immediately after the extraction of the mandibular first premolar. Implant surface characterization was performed by scanning electron microscopy attached to energy dispersive spectroscopy and interferometry. Three weeks after surgery, the animals were induced to death and undecalcified sections of the samples were prepared for histological and histomorphometrical analysis. RESULTS:Surface characterization of the implant demonstrated enhanced surface area of anodized group compared to Control group with 19.2% ± 6.2 versus 1.6 ± 0.7, respectively. Histological evaluation demonstrated new bone formation starting from the buccal and lingual cortical walls on both groups. After three weeks, significant higher bone contact of 27% (p<0.05) was observed to nanotextured compared to machined implants (Control group). CONCLUSION:The anodization with sodium sulfate nanostructures to the implant surface that resulted in faster osseointegration.

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Section: Discussionmentioning

confidence: 66%

“…We have recently reported bone remodeling of rabbit sockets grafted with hydroxyapatite based a novel approach 6 on the rabbit tooth extraction socket model 7 .…”

Section: Introductionmentioning

confidence: 99%

In-vivo bone response to titanium screw implants anodized in sodium sulfate

Pinheiro

Mourão

Diniz³

et al. 2014

Acta Cir. Bras.

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“…Mandibular incisor extraction was not preferred in order not to hinder the animal ability to eat and due to their continuous eruption that might disrupt normal healing. This is supported by Kuboki et al (10) who studied the alteration in collagen crosslinking after tooth extraction in rabbits and MansoI et al (11) who studied different biomaterials in the socket healing in rabbits.…”

Section: Discussionmentioning

confidence: 76%

Effect of Collatape® Collagen Wound Dressing Alone and Combined With Ingenios® Synthetic Bone Graft on the Socket Healing in Rabbits

Moustafa¹,

Omar

Osman

et al. 2015

Alexandria Dental Journal

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Introduction: Socket preservation enhances healing and reduces bone loss during healing of extraction socket. Objectives: To assess the effect of bio-absorbable collagen wound dressing (CollaTape®; Zimmer) on the of healing of extraction sockets in rabbits when applied alone and combined with IngeniOs Beta tricalcium phosphate (β-TCP) synthetic bone particles. Materials and methods: Sixteen rabbits were included in this study in which lower left first premolars were extracted and then divided into three groups including: Control group (4 animals) in which the sockets were left for normal healing, Collatape group (the sockets were closed with CollaTape collagen wound dressing alone) and IngeniOs β-TCP group (6 animals) in which the sockets were filled with synthetic bone particles and were closed with CollaTape collagen wound dressing. Euthanasia were done 2 and 6 weeks respectively. Socket healing was examined and evaluated histologically and analyzed histomorphometrically. Results: At 2 weeks of healing, it was observed in all groups that the sockets were filled with newly formed woven bone. The percentage of newly formed bone was lowest in control group followed by Collatape group while β-TCP group showed highest values. At 6 weeks healing period, the socket entrance was sealed with compact bone and the rest of the socket was filled with trabecular bone. β-TCP group showed the highest values of the percentage of the formed bone. Conclusions: It was confirmed that IngeniOs β-TCP enhances bone formation during socket healing and could be used for socket preservation

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“…A buccal mucoperiosteal flap was raised with a periosteal elevator to expose the extraction socket of first mandibular molar tooth. Bilateral extraction of the first mandibular molars of sixteen male rabbits was performed (Manso et al, 2011), divided at random into four groups (n= 4 in each group). Immediately after removing the teeth, in group 1 (control, no graft treatment), the extraction sockets (left and right) were left empty, to be filled with blood clot (Fig.…”

Section: Methodsmentioning

confidence: 99%

Alveolar Ridge Conservation by Early Bone Formation After Tooth Extraction in Rabbits: A Histomorphological Study

et al. 2015

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SUMMARY: Alveolar ridge volume loss is an irreversible process. To prevent this physiological event, which typically result in significant local anatomical changes in both the horizontal and the vertical dimension, some strategies are indicated to minimize the loss of ridge volume that typically follows tooth extraction. The purpose of this study was to evaluate if three different bone grafts could promote new bone formation in the alveolar socket following tooth extraction for the alveolar ridge conservation. First mandibular molars of male adults rabbits were extracted and the extraction sockets were randomly treated with three different bone grafts, one xenograft and two alloplastic grafts, and a group that received no treatment (blood clot). The extraction sockets of selected rabbits from each group were evaluated at 4, 6, or 8-week post-extraction. The results indicated that the extraction sockets treated with alloplastic graft (biphasic calcium phosphate) exhibited lamellar bone formation (6.5%) as early as four weeks after the extraction was performed. Moreover, the degree of new bone formation was significantly higher (P<0.05) in the extraction sockets treated with biphasic calcium phosphate at 8-week post-extraction than that in the other study groups. In this study, we demonstrated that the proposed animal model is useful to evaluate the bone formation after tooth extraction and the alveolar ridge conservation is feasible. The new bone formation and alveolar ridge preservation with bone graft after extraction of molar teeth, could result in the maintenance of sufficient bone volume to place an implant in an ideal restorative position without the need for ancillary implant site development procedures.

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Molars extraction for bone graft study in rabbits

Cited by 7 publications

References 16 publications

In-vivo bone response to titanium screw implants anodized in sodium sulfate

In-vivo bone response to titanium screw implants anodized in sodium sulfate

Effect of Collatape® Collagen Wound Dressing Alone and Combined With Ingenios® Synthetic Bone Graft on the Socket Healing in Rabbits

Alveolar Ridge Conservation by Early Bone Formation After Tooth Extraction in Rabbits: A Histomorphological Study

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