Changes in the volume and histology of endometriosis foci in rats treated with copaiba oil (Copaiferalangsdorffii)

Neto, João Nogueira; Lindoso, Márcio Jorge de Souza; Coelho, Laura Fernandes; Carvalho, Rafael Antonio Freire; Rodrigues, Taciana Gabrielle Pinheiro de Moura; Araújo, Ana Gisélia Portela de; Girão, Manuel João Batista Castelo; Schor, Eduardo

doi:10.1590/s0102-86502011000800005

Cited by 19 publications

(6 citation statements)

References 11 publications

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“…A previous report already validated that an oral formulation of copaiba oil can inhibit the growth of endometriotic lesions in rats. [ 200 ] Therefore, several research groups proposed that encapsulating copaiba oil extracts within nanomaterials may provide advantages for their bioavailability, delivery, safety, and therapeutic effect. [ 43,45,44 ]…”

Section: Nanoparticle‐based Treatment Modalitiesmentioning

confidence: 99%

Nanomedicines for Endometriosis: Lessons Learned from Cancer Research

Moses

Demessie

Taratula

et al. 2021

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Endometriosis is an incurable gynecological disease characterized by the abnormal growth of endometrium‐like tissue, characteristic of the uterine lining, outside of the uterine cavity. Millions of people with endometriosis suffer from pelvic pain and infertility. This review aims to discuss whether nanomedicines that are promising therapeutic approaches for various diseases have the potential to create a paradigm shift in endometriosis management. For the first time, the available reports and achievements in the field of endometriosis nanomedicine are critically evaluated, and a summary of how nanoparticle‐based systems can improve endometriosis treatment and diagnosis is provided. Parallels between cancer and endometriosis are also drawn to understand whether some fundamental principles of the well‐established cancer nanomedicine field can be adopted for the development of novel nanoparticle‐based strategies for endometriosis. This review provides the state of the art of endometriosis nanomedicine and perspective for researchers aiming to realize and exploit the full potential of nanoparticles for treatment and imaging of the disorder.

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Section: Nanoparticle‐based Treatment Modalitiesmentioning

confidence: 99%

Nanomedicines for Endometriosis: Lessons Learned from Cancer Research

Moses

Demessie

Taratula

et al. 2021

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“…Nogueira Neto et al . [ 33 ] tested the C. langsdorffii oleoresin on endometriosis foci in female rats, and found significant histological changes, with a reduction in volume of the endometrioses.…”

Section: Biological Studies With Crude Copaiba Oleoresinsmentioning

confidence: 99%

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

et al. 2012

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Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and diterpenes (labdane, clerodane and kaurane skeletons) are different for each Copaifera species and have been linked to several reported biological activities, ranging from anti-tumoral to embriotoxic effects. This review presents all the substances already described in this oleoresin, together with structures and activities of its main terpenoids.

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“…Thus, rendering the oleoresin an important natural remedy for people without access to commercial drugs (Ohsaki et al, 1994;Veiga Junior and Pinto, 2002;Leandro et al, 2012;Boaroto, 2014). Based on the comprehensive application in folk medicine, the oleoresin has been subject of various scientific studies aiming to prove its activity in different in vitro and in vivo models (Basile et al, 1988;Ohsaki et al, 1994;Veiga Junior et al, 2001;Lima et al, 2003;Paiva et al, 2004;Carvalho et al, 2005;Gomes et al, 2007;Veiga Junior et al, 2007;Gomes et al, 2008;Santos et al, 2008a;Santos et al, 2008b;Brito et al, 2010;Gomes et al, 2010;Santos Jr., 2010;Neto et al, 2011;Almeida et al, 2012;Dias et al 2014;Bardaji et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and cytotoxic effects of the Copaifera reticulata oleoresin and its main diterpene acids

Barbosa

Wenzel‐Storjohann

Barbosa

et al. 2019

Journal of Ethnopharmacology

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Ethnopharmacological relevance: The oleoresin of Brazilian Copaifera reticulata is a traditional remedy used for the treatment of skin and urinary tract infections, respiratory diseases, rheumatism, ulcer and tumours; thus, playing an important role in the primary health care of the indigenous population. Aim: As most previous pharmacological tests used the crude oleoresin and only a few studies so far dealt with enriched fractions or pure chemically defined compounds, the aim of this study was to systematically evaluate the antimicrobial and cytotoxic properties of the Copaifera reticulata oleoresin and to assign traditional uses to specific secondary metabolites. Materials and methods: The oleoresin, as well as its neutral and acidic fractions were tested for their activity against six cancer cell lines, two clinically relevant bacterial strains, and two dermatophytes. Both fractions were analysed by GC-MS and UHPLC-ELSD, respectively. The antibacterial acidic phase was further fractionated by preparative chromatography to purify and characterize the compounds responsible for the observed pharmacological effect. Results: Whereas no cytotoxic activity was detected, the crude oleoresin and its acidic fraction showed antibacterial activity against gram-positive bacteria Enterococcus faecium (IC50 values 4.2 and 4.8 µg/mL, respectively) and methicillin-resistant Staphylococcus aureus (MRSA, IC50 values 5.3 and 7.2 µg/mL, respectively). Purification of the acidic fraction of the C. reticulata oleoresin yielded two dicarboxylic diterpene acids and the four main diterpene acids, comprising three different diterpene scaffolds. Interestingly, the activity was not restricted to a particular diterpene-type but rather depended on the compounds' lipophilicity, with the most active constituent showing IC50 values of 1.6 (E. faecium) and 2.5 µg/mL (MRSA), respectively. Furthermore, ent-polyalthic acid, the major diterpenoid, was significantly active 3 against dermatophytes with IC50 values of 6.8 µg/mL (Trichophyton rubrum) and 4.3 µg/mL against (T. mentagrophytes). Conclusion: The present study proved the antimicrobial effects of the C. reticulata oleoresin and its diterpenoid constituents, confirming its wide use in folk medicine for the treatment of skin and urinary tract infections. The inhibitory activity of copaiba diterpenoids against dermatophytic fungi as well as the gram-positive bacteria E. faecium and MRSA is being reported for the first time, providing potential lead structures for the treatment of these clinically relevant bacterial strains.

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Changes in the volume and histology of endometriosis foci in rats treated with copaiba oil (Copaiferalangsdorffii)

Cited by 19 publications

References 11 publications

Nanomedicines for Endometriosis: Lessons Learned from Cancer Research

Nanomedicines for Endometriosis: Lessons Learned from Cancer Research

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

Antimicrobial and cytotoxic effects of the Copaifera reticulata oleoresin and its main diterpene acids

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