Inflammatory and oxidative stress after surgery for the small area corrections of burn sequelae

Abstract

Purpose: To compare vitamin levels, inflammatory and oxidative stress markers before and after skin autograft surgery to correct burn scar areas. Methods: This prospective study was conducted with 8 patients with a median age of 28 years (range, 16 to 40 years) that had burn sequelae and were admitted to a Burn Unit for correction of small burn scar areas [3.3 (1.0-5.0) % of the corporal surface].The volunteers were evaluated before and 48 hours after excision of scar tissue and skin autograft. Routine laboratory data, along with a food questionnaire and anthropometry were collected in the preoperative period. Serum vitamin A, C, E, B 12 and folic acid levels, inflammatory markers (C-protein reactive, alpha-1-acid glycoprotein, ferritin) and oxidative stress markers (reduced glutathione -GSH and Thiobarbituric Acid Reactive Substances -TBARS) were determined at preoperative and postoperative phases. Data were analyzed with two-sample Wilcoxon test. Results: All volunteers were clinically stable and had adequate nutritional status at admission. After surgery, C-reactive protein serum levels increased [0.4 (0.01-1.0) vs. 2.5 (0.6-4.7) mg/dL, p=0.01] and vitamin A levels decreased Inflammatory and oxidative stress after surgery for the small area corrections of burn sequelae e ferritina) e marcadores de estresse oxidativo (glutationa reduzida -GSH e Substâncias Reativas do Ácido Tiobarbitúrico -TBARS) foram determinados nas fases pré e pós-operatórias. Os dados foram analisados pelo teste de Wilcoxon pareado. Resultados: Todos os voluntários estavam clinicamente estáveis e apresentavam estado nutricional adequado à admissão hospitalar. Após a cirurgia, houve aumento dos níveis séricos de proteína C reativa [0,4 (0,01-1,0) vs 2,5 (0,6-4,7) mg/dL, p=0,01], enquanto houve redução nos níveis de vitamina A [3,4 (2,1-4,2) vs 2,4 (1,6-4,1) µmol/L, p=0,01]. Não houve mudanças nos níveis séricos de outras vitaminas, ferritina, alfa-1-glicoproteína ácida, GSH e TBARS. Conclusão: Em pacientes com bom estado nutricional e sem evidência de atividade inflamatória ou infecciosa ocorrem mudanças metabólicas mínimas após enxerto autólogo de pequenas áreas de cicatrizes de queimadura.

An Etiologic Profile of Anemia in 405 Geriatric Patients

“…Since fractures were the most frequent main cause of hospitalization in our study population, these patients came into the rehabilitation ward. Since an increase in inflammation parameters (CRP and ferritin) is to be expected under these circumstances, this represents an additional explanation for the high prevalence of AI in our study [22]. Studies of noninstitutionalized older persons have demonstrated higher and lower prevalences of IDA and AI, respectively [21, 23].…”

The postoperative redox status of patients with diabetes mellitus: a mini review

“…15 Even in cases where there are only small scar contractures, an increase in the levels of C-reactive protein is usually observed, leading to increased inflammatory stress. 16 Nevertheless, despite being an homeostatic mechanism, the inflammatory response could be overactivated and maintained after surgery, especially in patients with hyperglycemia, resulting in organ failure and increased mortality. 17 It has been reported that postoperative hyperglycemia occur in 20%-40% and 80% of patients after general and cardiac surgery, respectively.…”