The Effects of Different Burn Dressings on Length of Telomere and Expression of Telomerase in Children With Thermal Burns

Gürünlüoğlu, Kubilay; Demircan, Mehmet; Köç, Ahmet; Kocbiyik, Alper; Taşçı, Aytaç; Durmuş, Kübra; Gürünlüoğlu, Semra; Bağ, Harika Gözükara

doi:10.1093/jbcr/irz019

Cited by 6 publications

(12 citation statements)

References 42 publications

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“…In this regard, individuals with chronic obstructive pulmonary disease (COPD) show higher levels of telomerase compared to smokers' levels [54]. In addition, it is known that telomerase levels are higher in children that suffered burns and even higher in individuals with an amputated extremity [55]. In such a way, our results show an increase in telomerase levels in the post-treatment PG, as a possible mechanism that maintains the telomere, suggesting that the MetS per se leads to a gradual increase of the levels of this enzyme linked to greater DNA damage [56].…”

Section: Discussionmentioning

confidence: 99%

“…In such a way, our results show an increase in telomerase levels in the post-treatment PG, as a possible mechanism that maintains the telomere, suggesting that the MetS per se leads to a gradual increase of the levels of this enzyme linked to greater DNA damage [56]. This suggests that, despite such increment, it is not enough to avoid telomere shortening, due to a possible deficiency in the repair mechanisms and/or by the inactivation of the transcription factors that sense the damage generated by the OxS in the DNA [57]; this leads to chromosomal instability, telomere dysfunction, cell death or premature cell senescence [55]. In this regard, it has been proposed that an increase of telomerase activity can lead to a senescent phenotype [58].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Sechium edule var. nigrum spinosum (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

et al. 2020

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Patients with metabolic syndrome (MetS) have a redox imbalance, due to a decay in antioxidant capacity. Oxidative stress (OxS) is considered an important modulator of telomere shortening and telomerase activity. One of the fruits that has been associated with an antioxidant effect is Sechium edule and although its properties are well established, there is only one exploratory study evaluating its effectiveness in patients with MetS. The present investigation is a much more robust and controlled study, including a placebo group. Hence, we determined the effect of consumption of the dried fruit powder (500 mg, three times per day) for three months. We measured effects on telomerase levels, antioxidant capacity, and markers for OxS. The study was performed in a sample of 75 older adults: placebo group (n = 30) and experimental group (n = 45) with the diagnosis of MetS according to the National Adult Treatment Panel of the National Cholesterol Program III (NCEP/ATP III) criteria. All markers were measured before and after three months of treatment. There was a statistically significant decrease in lipoperoxides and protein carbonylation with an increased superoxide dismutase (SOD), as well as sustained levels of telomerase in patients who consumed Sechium edule. Our findings suggest that consumption of this fruit has a hypoglycemic, hypotensive, and antioxidant effect, without altering telomerase levels, which could suggest better protection against telomere shortening.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Sechium edule var. nigrum spinosum (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

et al. 2020

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“…Physical properties such as the adaptation of water vapor permeability over time supported by the body wound healing interactions made a new dressing and treatment scheme possible, reducing complications and the need for inner dressing changes, in contrast to other products [32,130]. A new understanding of lactate and its mechanism positively impacted the local and systemic inflammatory response and (hyper-) metabolism and cell regeneration compared to other products [28,78]. Lactate's effects on particular pain-related receptors could explain the strong pain-reducing effect [131].…”

Section: Discussionmentioning

confidence: 99%

“…Demircan demonstrated a substantial reduction in healing time after Suprathel ® treatment, possibly reducing oxidative stress and attenuating energy loss. This attenuation of energy balance might also lead to a reduction in areas that require skin grafts, as demonstrated by Uhlig et al [76], Schriek et al [77], and Blome-Eberwein et al [78].…”

Section: Effects Of Suprathel ® On the Energy Balancementioning

confidence: 93%

“…As demonstrated by Blome-Eberwein et al, Suprathel ® can reduce the number of patients with partial-thickness burns to be grafted from 20% previously to 0% of all cases, compared to historical SOC, after three weeks. Schriek et al showed that this reduced from 30% in the historical group to 7-9% after 11 days [77,78].…”

Section: The Practical Meaning Of the Reduction In Oxidative Stressmentioning

confidence: 96%

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Made in Germany: A Quality Indicator Not Only in the Automobile Industry But Also When It Comes to Skin Replacement: How an Automobile Textile Research Institute Developed a New Skin Substitute

et al. 2021

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Successful research and development cooperation between a textile research institute, the German Federal Ministry of Education and Research via the Center for Biomaterials and Organ Substitutes, the University of Tübingen, and the Burn Center of Marienhospital, Stuttgart, Germany, led to the development of a fully synthetic resorbable temporary epidermal skin substitute for the treatment of burns, burn-like syndromes, donor areas, and chronic wounds. This article describes the demands of the product and the steps that were taken to meet these requirements. The material choice was based on the degradation and full resorption of polylactides to lactic acid and its salts. The structure and morphology of the physical, biological, and degradation properties were selected to increase the angiogenetic abilities, fibroblasts, and extracellular matrix generation. Water vapor permeability and plasticity were adapted for clinical use. The available scientific literature was screened for the use of this product. A clinical application demonstrated pain relief paired with a reduced workload, fast wound healing with a low infection rate, and good cosmetic results. A better understanding of the product’s degradation process explained the reduction in systemic oxidative stress shown in clinical investigations compared to other dressings, positively affecting wound healing time and reducing the total area requiring skin grafts. Today, the product is in clinical use in 37 countries. This article describes its development, the indications for product growth over time, and the scientific foundation of treatments.

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The consumption of Sechium edule (chayote) has antioxidant effect and prevents telomere attrition in older adults with metabolic syndrome

et al. 2023

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Objective To determine the effect of the consumption of Sechium edule (1.5 g/day) for six months on oxidative stress (OxS) and inflammation markers and its association with telomere length (TL) in older adults with metabolic syndrome (MetS). Methods The study was conducted in a sample of 48 older adults: placebo (EP) and experimental (EG) groups. Lipoperoxides, protein carbonylation, 8-OHdG, total oxidant status (TOS), SOD, GPx, H 2 O 2 inhibition, total antioxidant status (TAS), inflammatory cytokines (IL6, IL10, TNF-α), and TL were measured before and six months post-treatment. Results We found a significant decrease in the levels of lipoperoxides, protein carbonylation, 8-OHdG, TOS in the EG in comparison PG. Likewise, a significante increase of TAS, IL-6, and IL-10 levels was found at six months post-treatment in EG in comparison with PG. TL showed a statistically significant decrease in PG compared to post-treatment EG. Conclusions Our findigns showed that the supplementation of Sechium edule has antioxidant, and anti-inflammatory effects, and diminushion of shortening of telomeric DNA in older adults with MetS. This would be the first study that shows that the intervention with Sechium edule has a possible geroprotective effect by preventing telomeres from shortening as usually happens in these patients. Therefore, suggesting a protection of telomeric DNA and genomic DNA.

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The Effects of Different Burn Dressings on Length of Telomere and Expression of Telomerase in Children With Thermal Burns

Cited by 6 publications

References 42 publications

Effect of Sechium edule var. nigrum spinosum (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

Effect of Sechium edule var. nigrum spinosum (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

Made in Germany: A Quality Indicator Not Only in the Automobile Industry But Also When It Comes to Skin Replacement: How an Automobile Textile Research Institute Developed a New Skin Substitute

The consumption of Sechium edule (chayote) has antioxidant effect and prevents telomere attrition in older adults with metabolic syndrome

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