2-hydroxyethyl methacrylate composite - polypropylene mesh for preventing peritoneal adhesions in female dogs

Abstract

Purpose: To evaluate whether the lining facing the visceral side of polypropylene mesh made with 2-hydroxyethyl methacrylate (p(HEMA)) hydrogel could avoid peritoneal adhesion in female dogs. Methods: Eight animals (group PP) had a polypropylene mesh implanted to correct a defect in the rectal abdominal muscle, whereas in the other group (group PH) the polypropylene mesh was coated with p(HEMA) composite on the surface facing the peritoneal area. Results: Adhesions were observed on the mesh in 62.5% of the PP group. In the PH group adhesions were present only on the suture lines. Conclusion: p(HEMA) hydrogel was well tolerated and effective in avoiding visceral and omental adhesions on the surface of the polypropylene mesh.

Role of Bovine Amniotic Membrane in Repair of Abdominal Muscle Defects in Dogs

“…Higher degrees of adhesion formation were encountered in animals where defects were repaired with PP alone (PP Group, Table 1, Figure 2). This could be attributed to the direct contact between the PP and the abdominal viscera leading to an inflammatory response to the prosthesis and giving rise to intra-abdominal adhesion (Silva et al, 2010). Table 1: Score of inflammation, neovascularization, and fibrosis and degree of adhesion in all experimental groups at 14 th and 28 th days post-surgery according to a semi-quantative grading scale described by Deeken and Mathews (2012).…”

Improving the antifouling properties of polypropylene surfaces by melt blending with polyethylene glycol diblock copolymers

“…Many studies have been conducted to alter the surfaces of materials by physical and chemical modifications . Decorating the surface with protein repellent coatings such as oligo‐ or poly(ethylene glycol) (PEG), 2‐hydroxyethyl methacrylate, sulfobetaine methacrylate, carboxybetaine methacrylate, 2‐methacryloyloxy‐ethyl phosphorylcholine, poly[ N ‐(2‐hydroxypropyl) methacrylamide], 3‐sulfopropyl‐methacrylate, and 2‐(tert‐butylamino)‐ethyl methacrylate have been studied.…”