Evaluation of peritoneal adhesions formation and tissue response to polypropylene - poli (2-hydroxyethyl methacrylate)-(polyHEMA) implant on rats' abdominal wall

Paulo, Neusa Margarida; Malmonge, Sônia Maria; Menezes, Liliana Borges de; Lima, Flávia Gontijo de; Faria, Aline de Moraes; Andrasckho, Mariana Moreira; Moreira, Natalia Menezes; Atayde, Ingrid Bueno; Silva, Marcelo Seixo de Brito e

doi:10.1590/s0102-86502010000400007

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Currently, three major approaches are taken to prevent or reduce post-surgical adhesion: minimizing surgical trauma, anti-fibrotic drugs, and the use of barriers [15]. A variety of materials, such as barrier membranes [16], gels [17] and degradable biocompatible polymers [18], have been applied to reduce adhesion formation by maintaining separation between serosal surfaces [19]. However, these materials are not widely used, due to problems associated with clinical application as well as other limiting factors [20].…”

Section: Resultsmentioning

confidence: 99%

The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats

Chen

Cheng

et al. 2012

IJMS

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Abdominal adhesions, whether caused by peritoneal trauma, radiation, infection, or a congenital condition, are associated with a wide range of complications. These complications include chronic abdominal or pelvic pain, infertility, and adhesive small bowel obstruction. Such adhesions render re-operation difficult, with attendant risks of inadvertent enterostomy and increased operation time. The purpose of this study was to investigate the potential of hyperbaric oxygen (HBO) therapy in the prevention of abdominal adhesions in an experimental animal study. A laparotomy was performed on Wistar rats to induce the formation of adhesions on the cecum and the intra-abdominal area (1 × 2 cm). A superficial layer of the underlying muscle from the right abdominal wall was also shaved and prepared for aseptic surgery. The rats were divided into four groups according to the duration of HBO therapy; five additional groups were designated according to the conditions of HBO therapy. When the rats were evaluated according to adhesion area and grade, a statistically significant difference was observed between the control and HBO treatment groups (p < 0.005). Results from this study suggest that HBO treatment could reduce adhesion formation; and further suggest that HBO therapy may have therapeutic potential in the treatment of postoperative peritoneal adhesion.

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Section: Resultsmentioning

confidence: 99%

The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats

Chen

Cheng

et al. 2012

IJMS

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“…Among the literatures, there are some related literatures on PP, PE and FE [12-16]. In these published data, there are some inflammatory reactions appeared attached sites [12-16]. Therefore, the knowledge of regional tissue responses to biomaterials is useful for diagnoses of pathological conditions in clinical sites.…”

Section: Discussionmentioning

confidence: 99%

Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use

et al. 2011

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Polypropylene (PP), Polyethylene (PE) and polytetra-fluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embeddingg site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.

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“…Paulo et al . 22 , in a study involving rats and polypropylene mesh implants versus polypropylene with poly-2-hydroxyethyl methacrylate (polyHEMA) hydrogel for abdominal wall defect correction, concluded that the composite mesh of polypropylene alone determined the appearance of adhesions throughout the surface of the mesh. In contrast, the mesh of polypropylene with hydrogel presented low numbers of adhesions with intra-abdominal viscera.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of peritoneal adhesions after intraperitoneal implantation in rats of meshes of polypropylene versus polypropylene/polyglecaprone versus polyester/porcine collagen

et al. 2019

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Purpose To Compare the extent and intensity of adhesions formed between the intra-abdominal organs and the intraperitoneal implants of polypropylene mesh versus polypropylene/polyglecaprone versus polyester/porcine collagen used for correction of abdominal wall defect in rats. Methods After the defect in the abdominal wall, thirty Wistar rats were placed in three groups (ten animals each) for intraperitoneal mesh implant: polypropylene group, polypropylene/polyglecaprone group, and polyester/porcine collagen group. The macroscopic evaluation of the extent and intensity of adhesions was performed 21 days after the implant. Results The polypropylene group had a higher statistically significant impairment due to visceral adhesions (p value = 0.002) and a higher degree of intense adherence in relation to polypropylene/polyglecaprone and polyester/porcine collagen groups (p value<0.001). The polyester/porcine collagen group showed more intense adhesions than the polypropylene/polyglecaprone group (p value=0.035). Conclusions The intraperitoneal implantation of polypropylene meshes to correct defects of the abdominal wall caused the appearance of extensive and firm adhesions to intra-abdominal structures. The use of polypropylene/polyglecaprone or polyester/porcine collagen tissue-separating meshes reduces the number and degree of adhesions formed.

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Evaluation of peritoneal adhesions formation and tissue response to polypropylene - poli (2-hydroxyethyl methacrylate)-(polyHEMA) implant on rats' abdominal wall

Cited by 5 publications

References 18 publications

The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats

The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats

Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use

Comparative study of peritoneal adhesions after intraperitoneal implantation in rats of meshes of polypropylene versus polypropylene/polyglecaprone versus polyester/porcine collagen

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